? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Prostacyclin is a member of the family of lipid molecules known as eicosanoids. ... In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is a research study. ... In medicine, pulmonary hypertension (PH) is an increase in blood pressure in the pulmonary artery or lung vasculature. ... Reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. ...
Clinical pharmacology
As an analogue of prostacyclin PGI2, beraprost effects vasodilation, which in turn lowers the blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined. The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Blood pressure is the pressure exerted by the blood on the walls of the blood vessels. ... A 250 ml bag of newly collected platelets. ...
Acenocoumarol, Clorindione, Dicumarol (Dicoumarol}, Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. ... An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... An antiplatelet drug is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Acenocoumarol is a anticoagulant that functions as a vitamin K antagonist (like warfarin). ... Dicumarol (or Dicoumarol) is a anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin). ... Phenprocoumon is a anticoagulant, functioning as a Vitamin K antagonist. ... Phenindione is an anticoagulant which functions as a Vitamin K antagonist. ... Warfarin (also known under the brand names of Coumadin®, Jantoven®, Marevan®, and Waran®) is an anticoagulant medication that is administered orally or, very rarely, by injection. ...
Heparin group (Platelet aggregation inhibitors):
Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. ... Dalteparin is a low molecular weight heparin. ... Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting thrombin. ... Enoxaparin is a low molecular weight heparin manufactured by Sanofi-Aventis. ... Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. ... In medicine, low molecular weight heparin (LMWH) is a class of medication used as an anticoagulant in diseases that feature thrombosis, as well as for prophylaxis in situations that lead to a high risk of thrombosis. ...
Other Platelet aggregation inhibitors:
Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal Abciximab (previously known as c7E3 Fab), distributed by Eli Lilly under the trade name ReoPro®, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. ... A very old bottle of Aspirin Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Clopidogrel (IPA: ) is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. ... Dipyridamole is a drug that inhibits platelet aggregation and causes vasodilation. ... Prostacyclin is a member of the family of lipid molecules known as eicosanoids. ... Eptifibatide (Integrilin®, Millennium Pharmaceuticals) is a anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. ... iloprost, an inhalation solution, is sold under the name Ventavis® and is used to treat pulmonary arterial hypertension (PAH). ... Prasugrel is a novel platelet inhibitor developed by Sankyo and produced by Ube and currently under clinical development in cooperation with Eli Lilly for acute coronary syndromes planned for PCI. Categories: Biochemistry stubs | Pharmacology stubs ... Ticlopidine is a drug used for its antiplatelet action. ... Tirofiban (INN, trade name Aggrastat®) is an anticoagulant drug. ... Trepostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. ...
Enzymes:
Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... // Basic Chemical, Pharmacological, and Marketing Information Ancrod (also known under its former brand name Arwin® and recently Viprinex®) is an anticoagulant with a triple mode of action. ... Anistreplase is a thrombolytic drug. ... // Basic Chemical, Pharmacological and Marketing Data Drotrecogin alpha (activated) is a recombinant form of human activated protein C that has antithrombotic, antiinflammatory, and profibrinolytic properties. ... // Basic Information Fibrinolysin is an enzyme derived from plasma of bovine origin or extracted from cultures of certain bacteria. ... Protein C is a major physiological anticoagulant. ... Reteplase (Retavase®) is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them. ... Streptokinase is an extracellular metallo-enzyme produced by beta-haemolytic streptococcus and is used as an effective and cheap clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. ... Tenecteplase is an enzyme used as a thrombolytic drug. ... Urokinase, also called urokinase-type Plasminogen Activator (uPA) is an enzyme (EC 3. ...
Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin. ... Argatroban is a small molecule direct thrombin inhibitor. ... Basic Chemical and Pharmacological Properties Bivalirudin is an anticoagulant and acts as direct thrombin antagonist. ... Dabigatran is an anticoagulant from the class of the direct thrombin inhibitors. ... Hirudin is a naturally ocurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. ... Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ...
Other antithrombotics:
Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban Dabigatran is an anticoagulant from the class of the direct thrombin inhibitors. ... // Basic Data Defibrotide is a deoxyribonucleic acid derivative (single stranded) derived from cow lung or porcine mucosa. ... Dermatan sulfate is a glycosaminoglycan, formerly called a mucopolysaccharide, found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs. ... Fondaparinux (Arixtra) is a medication that is an anticoagulant. ... Rivaroxaban (also known as BAY 59-7939) is an oral anticoagulant under development by Bayer. ...
Citrate, EDTA, Oxalate An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... Chemical strucutre of citric acid. ... EDTA is the chemical compound ethylenediaminetetraacetic acid. ... An oxalate (called also: ethanedioate) is a salt or ester of oxalic acid. ...
Beraprost sodium is an orally administered prostacyclin ana-log.
Oral beraprost was initiated at a rate of 60 mcg per day and increased by increments of 60 mcg per day over 1 to 2 weeks to the highest tolerated dosage.
Kaplan-Meier survival curves demonstrated the 1-, 2-, and 3-year survival rates in the beraprost group to be 96%, 86%, and 76%, respectively, compared with 77%, 47%, and 44%, respectively, in the conventional therapy group, differences that were statistically significant.
A recently completed U.S. trial of Beraprost failed to confirm the efficacy found in an earlier European trial, the company said.
United Therapeutics was expected to release the Beraprost results at the upcoming scientific meeting of the American Heart Association, starting Nov. 11.
Beraprost was being developed initially to treat patients suffering from intermittent claudication, or pain that results from a narrowing of arteries in the arms and legs.
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