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The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital. It strives to provide a comprehensive resource of Protein-Protein interactions for all major species while attempting to remove redundancy to create a single mapping of protein interactions. Users of The BioGRID can search for their protein of interest and retrieve annotation, as well as physical and genetic interaction data as reported, by the primary literature and compiled by in house large scale curation efforts. The BioGRID is hosted in Toronto, Ontario, Canada and is partnered with the Saccharomyces Genome Database. In software engineering, software maintenance is the process of enhancing and optimizing deployed software (software release), as well as remedying defects. ...
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The first Macintosh computer, introduced in 1984, upgraded to a 512K Fat Mac. The Macintosh or Mac, is a line of personal computers designed, developed, manufactured, and marketed by Apple Computer. ...
Microsoft Windows is a range of commercial operating environments for personal computers. ...
A software license is a legal agreement which may take the form of a proprietary or gratuitous license as well as a memorandum of contract between a producer and a user of computer software. ...
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As of 2006, there are over 1,000 public and commercial biological databases. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ...
The Official GRID Logo The General Repository for Interaction Datasets (GRID) is a curated biological database of protein-protein interactions created in 2003 by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital. ...
Mount Sinai Hospital Mount Sinai Hospital (MSH) is a hospital in Toronto, Ontario, Canada. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
In biology, a species is one of the basic units of biodiversity. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ...
Motto: Ut Incepit Fidelis Sic Permanet (Latin: Loyal she began, loyal she remains) Official languages English (French has some legal status but is not fully co-official) Flower White Trillium Tree Eastern White Pine Bird Common Loon Capital Toronto Largest city Toronto Lieutenant-Governor James K. Bartleman Premier Dalton McGuinty...
History
The BioGRID was originally published and released as simply the General Repository for Interaction Datasets but was later renamed to the BioGRID in order to more concisely describe the project, and help distinguish it from several unrelated projects with a similar name. Originally separated into organism specific databases, the newest version now provides a unified front end allowing for searches across several organisms simultaneously. The Official GRID Logo The General Repository for Interaction Datasets (GRID) is a curated biological database of protein-protein interactions created in 2003 by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital. ...
A crab is an example of an organism. ...
Abstract Access to unified datasets of protein and genetic interactions is critical for interrogation of gene/protein function and analysis of global network properties. BioGRID is a freely accessible database of physical and genetic interactions available at [2]. BioGRID release version 2.0 includes >116 000 interactions from Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens. Over 30 000 interactions have recently been added from 5778 sources through exhaustive curation of the Saccharomyces cerevisiae primary literature. An internally hyper-linked web interface allows for rapid search and retrieval of interaction data. Full or user-defined datasets are freely downloadable as tab-delimited text files and PSI-MI XML. Pre-computed graphical layouts of interactions are available in a variety of file formats. User-customized graphs with embedded protein, gene and interaction attributes can be constructed with a visualization system called Osprey that is dynamically linked to the BioGRID. Binomial name Saccharomyces cerevisiae Meyen ex E.C. Hansen Saccharomyces cerevisiae is a species of budding yeast. ...
Binomial name Caenorhabditis elegans Maupas, 1900 Caenorhabditis elegans (pronounced see-no-rab-DYE-tis) is a free-living nematode (one of the roundworms), about 1 mm in length, which lives in a temperate soil environment. ...
Binomial name Drosophila melanogaster Meigen, 1830 Drosophila melanogaster (from the Greek for black-bellied dew-lover) is a dipteran (two-winged) insect, and is the species of fruit fly that is most commonly used in genetic experiments; it is among the most important model organisms. ...
Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ...
Binomial name Saccharomyces cerevisiae Meyen ex E.C. Hansen Saccharomyces cerevisiae is a species of budding yeast. ...
Psi has multiple meanings: Psi (letter) (Ψ, ψ) of the Greek alphabet Psi (Cyrillic) (Ѱ, ѱ), letter of the early Cyrillic alphabet, adopted from Greek Psi (instant messenger), the popular Jabber client program J/ψ particle, a subatomic particle Schrödinger equation in quantum mechanics, ψ Ψ in mathematics is the angle between the tangent and the...
The Extensible Markup Language (XML) is a W3C-recommended general-purpose markup language for creating special-purpose markup languages, capable of describing many different kinds of data. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...
Binomial name Pandion haliaetus (Linnaeus, 1758) Subspecies (Linnaeus, 1758) Eurasian Osprey (Gmelin, 1788) North American Osprey Maynard, 1887 Caribbean Osprey (Vieillot, 1816) Australasian Osprey The Osprey (Pandion haliaetus) is a medium large raptor which is a specialist fish-eater with a worldwide distribution. ...
Supported Organisms The following organisms are currently supported within the BioGRID, but not all may contain interactions in the most recent build: Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ...
Binomial name Drosophila melanogaster Meigen, 1830 Drosophila melanogaster (from the Greek for black-bellied dew-lover) is a dipteran (two-winged) insect, and is the species of fruit fly that is most commonly used in genetic experiments; it is among the most important model organisms. ...
Binomial name Mus musculus Linnaeus, 1758 Mus musculus is the common house mouse. ...
Binomial name Caenorhabditis elegans Maupas, 1900 Caenorhabditis elegans (pronounced see-no-rab-DYE-tis) is a free-living nematode (one of the roundworms), about 1 mm in length, which lives in a temperate soil environment. ...
Binomial name Rattus norvegicus (Berkenhout, 1769) The Brown Rat or Norway Rat (Rattus norvegicus) is one of the most well-known and common rats, and also one of the largest. ...
Binomial name Danio rerio (Hamilton-Buchanan, 1822) The Zebra Danio or Zebrafish (Brachydanio rerio or Danio rerio) is a tropical fish belonging to the minnow family (Cyprinidae). ...
Binomial name Saccharomyces cerevisiae Meyen ex E.C. Hansen Saccharomyces cerevisiae is a species of budding yeast. ...
Binomial name Schizosaccharomyces pombe Schizosaccharomyces pombe, also called fission yeast, is a species of yeast. ...
Binomial name Arabidopsis thaliana (L.) Heynh. ...
Binomial name Bos taurus Linnaeus, 1758 Cattle are domesticated ungulates, a member of the subfamily Bovinae of the family Bovidae. ...
For other members of the dog family, see Canidae. ...
Binomial name Xenopus laevis Daudin, 1802 The African clawed frog (Xenopus laevis, also known as platanna) is a species of South African aquatic frog of the genus Xenopus. ...
References - Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, and Mike Tyers. BioGRID: A General Repository for Interaction Datasets. Nucleic Acids Res. Jan1;34:D535-9.
- Bobby-Joe Breitkreutz, Chris Stark, and Mike Tyers. The GRID: The General Repository for Interaction Datasets. Genome Biology 2003;3(12). PDF.
External links - BioGRID: Homepage
- Yeast GRID
- Fly GRID
- Worm GRID
- Mike Tyers Lab Homepage
- Samuel Lunenfeld Research Institute
- Flybase
- The Saccharomyces Genome Database
- Gene Ontology
- GeneDB
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