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Biochemical Diagnosis of Pheochromocytoma (5491 words) |
 | Measurements of the combined sum of urinary outputs of normetanephrine and metanephrine in sulfate-conjugated plus free form (commonly known as urinary total metanephrines), as measured by out-dated spectrofluorometric methods, are not sensitive tests of a pheochromocytoma and have limited value in the initial work-up of a patient suspected of having a pheochromocytoma. |
| Ultimately, it is a combination of biochemical and radiological tests combined with clinical assessment of symptoms, signs and associated conditions that provides the clinician with sufficient evidence to establish or refute the diagnosis of pheochromocytoma. |
| This pattern of biochemical test results combined with a negative clonidine suppression test result (i.e., a substantial decrease in plasma norepinephrine after clonidine) is highly suggestive of sympathetic activation rather than a tumor, and, unless imaging studies suggest otherwise, a pheochromocytoma can be excluded and no further tests should be necessary. |
| Postgraduate Medicine: Osteoporosis Symposium: Biochemical markers of bone turnover (3168 words) |
| Biochemical markers can detect women who are considered "rapid losers" (ie, those who lose 3% to 5% of bone per year). |
| Biochemical marker measurements can differ in response to specific osteoporosis therapies and may even vary in the same patient. |
| Biochemical markers of bone turnover allow clinicians to evaluate the risk of bone loss and provide insight into response to therapy. |
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