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The Centers for Disease Control and Prevention specifies four levels of biosafety precautions for biological agents. WHY IS THE CDC headquartered in Atlanta? Who made this decision? Was it political? Was there a powerful senator/politician? PLease answer!! The Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, is recognized as the lead United States agency for protecting the public health and safety of people...
A sampling of Bacillus anthracis—Anthrax A biological agent is an infectious disease that can be used in bioterrorism or biological warfare. ...
An example of a Biosafety lab is USAMRIID (U.S. Army Medical Research Institute for Infectious Diseases.) The U.S. Army Medical Research Institute of Infectious Diseases is based at Fort Detrick, Frederick, Maryland. ...
Level 1
Biosafety Level 1 is suitable for work involving well-characterized agents not known to consistently cause disease in healthy adult humans, and of minimal potential hazard to laboratory personnel and the environment. The laboratory is not necessarily separated from the general traffic patterns in the building. Work is generally conducted on open bench tops using standard microbiological practices. Special containment equipment or facility design is neither required nor generally used. Laboratory personnel have specific training in the procedures conducted in the laboratory and are supervised by a scientist with general training in microbiology or a related science. Microbiology (in Greek micron = small and biologia = studying life) is the study of microorganisms, including viruses, viroids, prions, prokaryotes and simple eukaryotes (e. ...
Level 2 Biosafety Level 2 is similar to Biosafety Level 1 and is suitable for work involving agents of moderate potential hazard to personnel and the environment. It differs from BSL-1 in that - laboratory personnel have specific training in handling pathogenic agents and are directed by competent scientists;
- access to the laboratory is limited when work is being conducted;
- extreme precautions are taken with contaminated sharp items; and
- certain procedures in which infectious aerosols or splashes may be created are conducted in biological safety cabinets or other physical containment equipment.
Level 3 Biosafety Level 3 is applicable to clinical, diagnostic, teaching, research, or production facilities in which work is done with indigenous or exotic agents which may cause serious or potentially lethal disease as a result of exposure by the inhalation route. Laboratory personnel have specific training in handling pathogenic and potentially lethal agents, and are supervised by competent scientists who are experienced in working with these agents.
All procedures involving the manipulation of infectious materials are conducted within biological safety cabinets or other physical containment devices, or by personnel wearing appropriate personal protective clothing and equipment. The laboratory has special engineering and design features.
It is recognized, however, that some existing facilities may not have all the facility features recommended for Biosafety Level 3 (i.e., double-door access zone and sealed penetrations). In this circumstance, an acceptable level of safety for the conduct of routine procedures, (e.g., diagnostic procedures involving the propagation of an agent for identification, typing, susceptibility testing, etc.), may be achieved in a Biosafety Level 2 facility, providing
- the exhaust air from the laboratory room is discharged to the outdoors,
- the ventilation to the laboratory is balanced to provide directional airflow into the room,
- access to the laboratory is restricted when work is in progress, and
- the recommended Standard Microbiological Practices, Special Practices, and Safety Equipment for Biosafety Level 3 are rigorously followed.
The decision to implement this modification of Biosafety Level 3 recommendations should be made only by the laboratory director.
Level 4 Biosafety Level 4 is required for work with dangerous and exotic agents that pose a high individual risk of aerosol-transmitted laboratory infections and life-threatening disease. Agents with a close or identical antigenic relationship to Biosafety Level 4 agents are handled at this level until sufficient data are obtained either to confirm continued work at this level, or to work with them at a lower level.
Members of the laboratory staff have specific and thorough training in handling extremely hazardous infectious agents and they understand the primary and secondary containment functions of the standard and special practices, the containment equipment, and the laboratory design characteristics. They are supervised by competent scientists who are trained and experienced in working with these agents. Access to the laboratory is strictly controlled by the laboratory director.
The facility is either in a separate building or in a controlled area within a building, which is completely isolated from all other areas of the building. A specific facility operations manual is prepared or adopted.
Within work areas of the facility, all activities are confined to Class III biological safety cabinets, or Class II biological safety cabinets used with one-piece positive pressure personnel suits ventilated by a life support system. The Biosafety Level 4 laboratory has special engineering and design features to prevent microorganisms from being disseminated into the environment.
Australia The Australian Animal Health Laboratory in Geelong is Australia's only BSL4 facility. - - Nickname: City by the Bay Geography Area: 1,240 km² Coordinates: Time Zone UTC +10:00 Population (2003) 200,067 Among Australian cities: Density: persons/km² Political Mayor: Shane Dowling Governing body: City of Greater Geelong Geelong is a port city of 200,067 people (2003 census) located on Corio...
Canada Canada has at least one BSL4 facility, located in the Government of Canada laboratories in Winnipeg. Motto: Unum Cum Virtute Multorum (One With the Strength of Many) Area: 465. ...
France France maintains a P4 laboratory in Lyon. City motto: Avant, avant, Lion le melhor. ...
USA The United States maintains a number of Biosafety Level 4 facilities: - USAMRIID in Fort Dietrich, MD
- CDC in Atlanta, GA
- NNMC in Bethesda, MD
- Southwest Foundation for Biomedical Research in San Antonio, TX
- UTMB's National Biocontainment Laboratory in Galveston, TX
- NIAID's Rocky Mountain Laboratories in Hamilton, MT
- Boston University is hoping to construct the BSL-4 NEIDL facility in Boston, MA
UC Davis bid for, but did not receive permission to construct one. Utah State University is also considering constructing a BSL-4 facility. Eventually, there may be one in each of 10 areas in the US. The U.S. Army Medical Research Institute of Infectious Diseases is based at Fort Detrick, Frederick, Maryland. ...
The Centers for Disease Control and Prevention (CDC) in Atlanta is recognized as the lead United States agency for protecting the public health and safety of people by providing credible information to enhance health decisions, and promoting health through strong partnerships with state health departments and other organizations. ...
The National Naval Medical Center in Bethesda, Maryland, also known as the Bethesda Naval Hospital, is considered the flagship of the United States Navys system of medical centers. ...
The University of Texas Medical Branch at Galveston (UTMB) is a component of the University of Texas System located in Galveston, Texas. ...
National Institute of Allergy and Infectious Diseases (NIAID) is a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. ...
Boston University is a non-sectarian private university located in Boston, Massachusetts. ...
See also The biological hazard symbol Immediate disposal of used needles into a sharps container is standard procedure. ...
Safety engineering is an applied science strongly related to systems engineering. ...
Security engineering is the field of engineering dealing with the security and integrity of real-world systems. ...
External links - http://www.cdc.gov/od/ohs/biosfty/bmbl4/bmbl4s3.htm
- http://www.cdc.gov/od/ohs/biosfty/biosfty.htm
- Biological agents, and recommended biosafety levels for handling them
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