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Encyclopedia > Biological halflife

The biological half life of a substance is the time required for half of that substance to be removed from an organism by either a physcial or a chemical process.


While a radioactive substance decays perfectly according to first order kinetics where the rate constant is fixed, the elimination of a substance from a living organism follows more complex kinetics. Radioactive decay is the set of various processes by which unstable atomic nuclei (nuclides) emit subatomic particles. ...

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Alcohol

For instance, the removal of ethanol (alcohol) through oxidation by alcohol dehydrogenase in the liver from the human body is limited. Hence the removal of a large concentration of alcohol from blood may follow zero order kinetics. Also the rate limiting steps for one substance may be in common with other substances. For instance, the blood alcohol concentration can be used to modify the biochemistry of methanol and ethylene gycol. In this way the oxidation of methanol to the toxic formaldehyde and formic acid in the human body can be prevented by giving a person who has ingested methanol an alcoholic drink. Note that methanol is very toxic and causes blindness and death. In the same way a person who has injested ethylene gycol can be treated. This article has been identified as possibly containing errors. ... In general usage, alcohol (from Arabic al-kukhūl الكحول = the spirit, the chemical.) refers almost always to ethanol, also known as grain alcohol, and often to any beverage that contains ethanol (see alcoholic beverage). ... Alcohol Dehydrogenase Alcohol dehydrogenases are a group of dehydrogenase enzymes that occur in many organisms and facilitate the conversion between alcohols and aldehydes or ketones. ... The liver is one of the largest internal organs of the human body. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Methanol, also known as methyl alcohol or wood alcohol, is a chemical compound with chemical formula CH3OH. It is the simplest alcohol, and is a light, volatile, colourless, tasteless, flammable, poisonous liquid with a very faint odor. ... For a list of biologically injurious substances, including toxins and other materials, as well as their effects, see poison. ... The chemical compound formaldehyde (also known as methanal), is a gas with a strong pungent smell. ... Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. ... In general terms, eating (formally, ingestion) is the process of consuming something edible, i. ... See also Blindness (novel) Blindness can be defined physiologically as the condition of lacking visual perception. ...


Water

The biological half life of water in a human is about 7 to 10 days. It can be altered by behaviour. Drinking large amounts of beer will reduce the biological half life of water in the body. This has been used to decontaminate humans who are internally contaminated with tritiated water (tritium). Drinking the same amount of water would have a similar effect, but many would find it difficult to drink a large volume of water. The basis of this decontamination method (used as Harwell) is to increase the rate at which the water in the body is replaced with new water. A mug of lager beer, showing the golden colour of the beer and the foamy head floating on top. ... Tritium (symbol T or 3H) is a radioactive isotope of hydrogen. ... Harwell may refer to: Harwell - a village in Oxfordshire RAF Harwell - a World War II RAF airfield Harwell Laboratory of the Atomic Energy Research Establishment, the site of Europes first nuclear reactor. ...


Metals

The biological half life of caesium in humans is between one and four months. This can be shortened by feeding the person prussian blue. The prussian blue in the digestive system acts as a solid ion exchanger which absorbs the caesium while releasing potassium ions. General Name, Symbol, Number caesium, Cs, 55 Chemical series alkali metals Group, Period, Block 1, 6, s Appearance silvery gold Atomic mass 132. ... Prussian Blue is a pigment, see Prussian blue It is also the name of a number of musical groups: Prussian Blue (British band) Prussian Blue (American duo) This is a disambiguation page: a list of articles associated with the same title. ... Ion exchange is a process in which ions are exchanged between a solution and an ion exchanger, an insoluble solid or gel. ... General Name, Symbol, Number potassium, K, 19 Chemical series alkali metals Group, Period, Block 1, 4, s Appearance silvery white Atomic mass 39. ...


For some substance, is it important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half life. Attempts to remove a substance from the whole organism may have the effect of increasing the burden present in one part of the organism. For instance, if a person who is contaminated with lead is given EDTA in a chelation therapy, then while the rate at which lead is lost from the body will be increased, the lead within the body tends to relocate into the brain where it can do the most harm. EDTA EDTA is the chemical compound ethylenediaminetetraacetic acid, otherwise known as edetate, versene, or diaminoethanetetraacetic acid disodium salt. ... Chelation therapy is a process involving the use of chelating agents such as EDTA to remove heavy metals from the body. ... Comparative brain sizes In animals, the brain, or encephalon (Greek for in the head), acts as the control center of the central nervous system. ...

  • Cesium in the body has a biological half life of about one to four months.
  • Lead in bone has a biological half life of about ten years.
  • Cadmium in bone has a biological half life of about 30 years.
  • plutonium in bone has a biological half life of about 100 years.
  • plutonium in the liver has a biological half life of about 40 years.

A substance can have an effect on the health of a person long after the substance has left the body. For example, a car crash under the influence of chemicals may have consequences long into the future. A carcinogenic substance may cause cancer cells to appear, which may continue to multiply even after exposure to the carcinogen has stopped. General Name, Symbol, Number lead, Pb, 82 Chemical series poor metals Group, Period, Block 14, 6, p Appearance bluish white Atomic mass 207. ... Grays illustration of a human femur, a typically recognized bone. ... General Name, Symbol, Number cadmium, Cd, 48 Chemical series transition metals Group, Period, Block 12, 5, d Appearance silvery gray metallic Atomic mass 112. ... Grays illustration of a human femur, a typically recognized bone. ... General Name, Symbol, Number plutonium, Pu, 94 Chemical series actinides Group, Period, Block n/a, 7, f Appearance silvery white Atomic mass (244) g/mol Electron configuration [Rn] 5f6 7s2 Electrons per shell 2, 8, 18, 32, 24, 8, 2 Physical properties Phase solid Density (near r. ... Grays illustration of a human femur, a typically recognized bone. ... General Name, Symbol, Number plutonium, Pu, 94 Chemical series actinides Group, Period, Block n/a, 7, f Appearance silvery white Atomic mass (244) g/mol Electron configuration [Rn] 5f6 7s2 Electrons per shell 2, 8, 18, 32, 24, 8, 2 Physical properties Phase solid Density (near r. ... The liver is one of the largest internal organs of the human body. ... In pathology, a carcinogen is any substance or agent that promotes cancer. ...


Prozac

Also, some substances migrate slowly from the brain to the blood, for instance Prozac {N-methyl-3-phenyl-3-(4-trifluoromethylphenoxy) propyl amine} remains a long time in the brain because it is lipophilic. This is one of the things which makes prozac's biological halflife in the brain long. Comparative brain sizes In animals, the brain, or encephalon (Greek for in the head), acts as the control center of the central nervous system. ... Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Background Fluoxetine hydrochloride (brand names include Prozac®, Symbyax® (compounded with olanzapine), Sarafem®, Fontex® (Sweden), Fluctine (Austria, Germany), Prodep (India), Fludac (India)) is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder, and many other disorders. ... In chemistry, hydrophobic or lipophilic species, or hydrophobes, tend to be electrically neutral and nonpolar, and thus prefer other neutral and nonpolar solvents or molecular environments. ...


  Results from FactBites:
 
Encyclopedia: Nuclear power (10256 words)
Renewable energy (sources) or RES capture their energy from existing flows of energy, from on-going natural processes, such as sunshine, wind, flowing water, biological processes, and geothermal heat flows.
The nuclear reactors are inside the cylindrical containment buildings to the right - left is a cooling tower venting water vapor (literally a cloud).
In general, fast-spectrum reactors will produce less waste, and the waste they do produce will have a vastly lower halflife, but they are more difficult to build, and more expensive to operate.
Heptachlor (PIM 578) (4506 words)
It causes a 6 to 11-fold increase in the liver heptachlor epoxidase (Miranda et al., 1973).
Epoxidation is an important metabolic route leading to heptachlor epoxide, which is of comparable toxicity to heptachlor but more stable in biological systems.
ACGIH (2000) Threshold limit values for chemical substances and physical agents and biological exposure indices.
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