The Bisaltae were a Thracian people on the lower Strymon river, in the district between Amphipolis and Heraclea Sintica on the east and Crestonice on the west. They also made their way into the peninsulas of Acte and Pallene in the south, beyond the river Nestus in the east, and are even said to have raided Cardia.

Under a separate king at the time of the Persian Wars, they were annexed by Alexander I (498 BC_454 BC) to the kingdom of Macedonia. At the division of Macedonia into four districts by the Romans after the battle of Pydna (168) the Bisaltae were included in Macedonia Prima.

Their country was rich in figs, vines and olive trees; the silver mines in the mountain range of Dysorum brought in a talent a day to their conqueror Alexander. The Bisaltae are referred to by Virgil in connection with the treatment of the diseases of sheep. The fact that their eponymus is said to have been the son of Helios and Ge points to a very early settlement in the district.