The Blaise reaction is a chemical reaction that forms a β-ketoester from the reaction of zinc metal with a α-bromoester and a nitrile. The final intermediate is a metaloimine, which is hydrolyzed to give the desired β-ketoester. A chemical reaction is a process involving one, two or more substances (called reactants), characterized by a chemical change and yielding one or more product(s) which are different from the reactants. ... General Name, Symbol, Number zinc, Zn, 30 Chemical series transition metals Group, Period, Block 12, 4, d Appearance bluish pale gray Atomic mass 65. ... A nitrile is an organic compound which has a -CN functional group. ... Hydrolysis is a chemical process in which a molecule is cleaved into two parts by the addition of a molecule of water. ...
References
Blaise, E. E.; Compt. Rend.1901, 132, 478.
Cason, J. et al.; J. Org. Chem.1953, 18, 1594.
Hannick, S. M.; Kishi, Y.; J. Org. Chem.1983, 48, 3833.
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