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Blood sugar regulation is the process by which the levels of blood sugar, primarily glucose, are maintained by the body. Image File history File links Download high-resolution version (1100x603, 38 KB) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Glucose ...
Image File history File links Download high-resolution version (1100x603, 38 KB) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Glucose ...
Glucose (Glc), a monosaccharide (or simple sugar), is the most important carbohydrate in biology. ...
In medicine, blood sugar is a term used to refer to levels of glucose in the blood. ...
Glucose (Glc), a monosaccharide (or simple sugar), is the most important carbohydrate in biology. ...
Mechanisms of blood sugar regulation
Blood sugar levels are regulated by negative feedback in order to keep the body in homeostasis. The levels of glucose in the blood are monitored by the cells in the pancreas. If the blood glucose level falls to dangerous levels (as in very heavy exercise or lack of food for extended periods), the Alpha cells of the pancreas release glucagon, a hormone whose effects on liver cells act to increase blood glucose levels. They convert glycogen storage into glucose (this process is called glycogenolysis). The glucose is released into the bloodstream, increasing blood sugar levels. Negative feedback (shortened to NFB) is a type of feedback in which the system responds in an opposite direction to the perturbation. ...
It has been suggested that Reactive homeostasis be merged into this article or section. ...
Glucose (Glc), a monosaccharide (or simple sugar), is the most important carbohydrate in biology. ...
The pancreas is an organ in the digestive and endocrine system that serves two major functions: exocrine (producing pancreatic juice containing digestive enzymes) and endocrine (producing several important hormones, including insulin). ...
Alpha cells are endocrine cells in the islets of Langerhans of the pancreas. ...
Glucagon ball and stick model A microscopic image stained for glucagon. ...
Norepinephrine A hormone (from Greek ÏÏμή - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ...
Electron micrograph of a section of a liver cell showing glycogen deposits as accumulations of electron dense particles (arrows). ...
Glycogenolysis is the catabolism of glycogen (requiring removal of glucose unit from glycogen and addition of phosphate) thus producing glucose 1-phosphate, and subsequently reconfigured (C-1 -> C-6) to yield glucose 6-phosphate, a potent reaction intermediary leading to glucose available to the blood and brain, pyruvic acid (yet...
There are also several other causes for an increase in blood sugar levels. Among them are the 'stress' hormones such as adrenalin, several of the steroids, infections, trauma, and of course, the ingestion of food. When levels of blood sugar rise, whether as a result of glycogen conversion, or from digestion of a meal, a different hormone is released from beta cells found in the Islets of Langerhans in the pancreas. This hormone, insulin, causes the liver to convert more glucose into glycogen (this process is called glycogenesis), and to force about 2/3 of body cells (primarily muscle and fat tissue cells) to take up glucose from the blood, thus decreasing blood sugar levels. Insulin also provides signals to several other body systems, and is the chief regulatory metabolic control in humans. Beta cells are a type of cell in the pancreas in areas called the islets of Langerhans. ...
The endocrine (i. ...
Insulin (from Latin insula, island, as it is produced in the Islets of Langerhans in the pancreas) is a polypeptide hormone that regulates carbohydrate metabolism. ...
Glycogenesis is the process of glycogen synthesis, in which glucose molecules are added to chains of glycogen. ...
A top-down view of skeletal muscle Muscle (from Latin musculus little mouse[1]) is contractile tissue of the body and is derived from the mesodermal layer of embryonic germ cells. ...
Diabetes mellitus type 1 is caused by insufficient or non-existent production of insulin, while type 2 is primarily due to a decreased response to insulin in the tissues of the body (insulin resistance). Both types of diabetes, if untreated, result in too much glucose remaining in the blood (hyperglycemia) and many of the same complications. Also, too much insulin and/or exercise without enough corresponding food intake in diabetics can result in low blood sugar (hypoglycemia). For the disease characterized by excretion of large amounts of severely diluted urine, see diabetes insipidus. ...
Insulin resistance is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. ...
Hyperglycemia or High Blood Sugar is a condition in which an excessive amount of glucose circulates in the blood plasma. ...
Hypoglycemia (hypoglycæmia in the UK) is a medical term referring to a pathologic state produced by a lower than normal amount of sugar (glucose) in the blood. ...
Hormones that influence blood glucose level | Hormone | Tissue of Origin | Metabolic Effect | Effect on Blood Glucose | | Insulin | Pancreatic β Cells | 1) Enhances entry of glucose into cells; 2) Enhances storage of glucose as glycogen, or conversion to fatty acids; 3) Enhances synthesis of fatty acids and proteins; 4) Suppresses breakdown of proteins into amino acids, of adipose tissue into free fatty acids. | Lowers | | Somatostatin | Pancreatic D Cells | 1) Suppresses glucagon release from α cells (acts locally); 2) Suppresses release of Insulin, Pituitary tropic hormones, gastrin and secretin. | Raises | | Glucagon | Pancreatic α cells | 1) Enhances release of glucose from glycogen; 2) Enhances synthesis of glucose from amino acids or fatty acids. | Raises | | Epinephrine | Adrenal medulla | 1) Enhances release of glucose from glycogen; 2) Enhances release of fatty acids from adipose tissue. | Raises | | Cortisol | Adrenal cortex | 1) Enhances gluconeogenesis; 2) Antagonizes Insulin. | Raises | | ACTH | Anterior pituitary | 1) Enhances release of cortisol; 2) Enhances release of fatty acids from adipose tissue. | Raises | | Growth Hormone | Anterior pituitary | Antagonizes Insulin | Raises | | Thyroxine | Thyroid | 1) Enhances release of glucose from glycogen; 2) Enhances absorption of sugars from intestine | Raises | Pediatric endocrinology - Neuroendocrinology - Reproductive endocrinology - Calcium metabolism - Blood sugar regulation - Endocrine glands Insulin (from Latin insula, island, as it is produced in the Islets of Langerhans in the pancreas) is a polypeptide hormone that regulates carbohydrate metabolism. ...
Beta cells are a type of cell in the pancreas in areas called the islets of Langerhans. ...
It has been suggested that Subcutaneous fat be merged into this article or section. ...
Somatostatin is a hormone. ...
In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ...
Secretin is a peptide hormone produced in the S cells of the duodenum. ...
Glucagon ball and stick model A microscopic image stained for glucagon. ...
Adrenaline redirects here. ...
In mammals, the adrenal glands are the triangle-shaped endocrine glands that sit atop the kidneys. ...
Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. ...
Layers of cortex. ...
Pyruvic acid Oxaloacetic acid Phosphoenolpyruvate Fructose 1,6-bisphosphate Fructose 6-phosphate Glucose-6-phosphate Glucose Gluconeogenesis is the generation of glucose from non-sugar carbon substrates like pyruvate, lactate, glycerol, and amino acids (primarily alanine and glutamine). ...
Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. ...
The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ...
Growth hormone (GH or somatotropin) is a 191 amino acid, single chain polypeptide hormone which is synthesised, stored and secreted by the stomatotraph cells within the lateral wings of the anterior pituitary gland, which stimulates growth and cell reproduction in humans and other vertebrate animals. ...
The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ...
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...
Endocrinology is a branch of medicine dealing with disorders of the endocrine system and its specific secretions called hormones. ...
Pediatric endocrinology is a medical subspecialty dealing with variations of physical growth and sexual development in childhood, as well as diabetes and other disorders of the endocrine glands. ...
Neuroendocrinology is the study of the interactions between the nervous system and the endocrine system. ...
Reproductive endocrinology (RE) is a medical subspecialty that addresses hormonal functioning as it pertains to reproduction. ...
Calcium metabolism or calcium homeostasis is the mechanism by which the body maintains adequate calcium levels. ...
An endocrine gland is one of a set of internal organs involved in the secretion of hormones into the blood. ...
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