Bloodlines are a fictional category of vampires, from White Wolf Game Studio's role-playing games Vampire: The Masquerade and Vampire: The Requiem. While the term clan refers to considerably populous and well-known groups, Bloodline refers to smaller groups.

In both of White Wolf's Vampire games, vampires create other vampires by draining all the victim's blood and providing a drop of the progenitor's vitae. Because of this, the childe shares many attributes of the sire.

In Vampire: The Requiem, the childe of a member of a bloodline always belongs to that bloodline's parent clan. To become a member of a bloodline, the childe must join one through force of will, though in some cases this can happen unconsciously. A vampire can only join bloodlines that split off from her own clan, but she is not limited to her sire's bloodline if her sire belongs to one. Vampires of sufficient age and potency of blood may create their own bloodlines rather than joining ones already established; the process is one-way, and no vampire may belong to more than one bloodline. The advantage of creating or joining a bloodline is easier access to a new Discipline.

The full list of bloodlines mentioned so far in Vampire: The Requiem is as follows: Duchagne, Toreador, and Xiao (Daeva); Anavashra, Anubi, Bruja, Matasuntha, and Taifa (Gangrel); Agonistes, Mnemosyne, Morbus, Norvegi, and Sangiovanni (Mekhet); Acteius, Badacelli, Burakumin, Noctuku, and Yagnatia (Nosferatu); and Bene Murrahim, Cassian Ventrue, Licinni Ventrue, Malkovian, and Rötgrafen (Ventrue).

In Vampire: The Masquerade the childe of a vampire who belongs to a bloodline will always belong to the same bloodline as her sire, and there's no set way to change one's lineage. Bloodlines in Masquerade are generally the product of unique supernatural events, and are functionally just smaller clans. Unlike in Vampire: The Requiem, bloodlines in Vampire: The Masquerade aren't necessarily tied to specific clans.

The exhaustive list of bloodlines in Vampire: The Masquerade is as follows: Ahrimanes, Akunanse, Assamite antitribu, Baali, Blood Brothers, Brujah antitribu, Bushi, Daughters of Cacaphony, Gaki, Gangrel antitribu, Gargoyles, Guruhi, Harbingers of Skulls, Ishtarri, Kiasyd, Kinyonyi, Laibon, Lamia, Lasombra antitribu, Lhiannan, Malkavian antitribu, Nagaraja, Naglopers, Nosferatu antitribu, Old Clan Tzimisce, Osebo, Panders, Ravnos antitribu, Salubri, Salubri antitribu, Samedi, Serpents of the Light, Shango, Toreador antitribu, True Brujah, Tzimisce kolduns, Ventrue antitribu, and Xi Dundu.