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Encyclopedia > Bombesin

Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. Phenylalanine is one of the standard amino acids. ... Peptides (from the Greek πεπτος, digestible), are the family of short molecules formed from the linking, in a defined order, of various α-amino acids. ... Beyond overall skin structure, refer below to: See-also. ... Distribution of frogs (in black) Suborders Archaeobatrachia Mesobatrachia Neobatrachia - List of Anuran families The frogness babe is an amphibian in the order Anura (meaning tail-less from Greek an-, without + oura, tail), formerly referred to as Salientia (Latin saltare, to jump). ... Orders Subclass Monotremata Monotremata Subclass Marsupialia Didelphimorphia Paucituberculata Microbiotheria Dasyuromorphia Peramelemorphia Notoryctemorphia Diprotodontia Subclass Placentalia Xenarthra Dermoptera Desmostylia Scandentia Primates Rodentia Lagomorpha Insectivora Chiroptera Pholidota Carnivora Perissodactyla Artiodactyla Cetacea Afrosoricida Macroscelidea Tubulidentata Hyracoidea Proboscidea Sirenia The mammals are the class of vertebrate animals primarily characterized by the presence of mammary... Neuromedin B (NMB) is a bombesin-related peptide in mammals. ... Gastrin releasing peptide (GRP) is released by the post-ganglionic fibres of the vagus nerve which innervate the G cells of the stomach and stimulate them to release gastrin. ... Upper and Lower gastrointestinal tract The gastrointestinal tract (GI tract), also called the digestive tract, or the alimentary canal, is the system of organs within multicellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. ... redirect Template:Db-reason synaptophysin ... Norepinephrine A hormone (from Greek όρμή - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... In medicine, the G cell is a type of cell in the stomach that secrets gastrin. ... G-proteins, short for guanine nucleotide binding proteins, are a family of proteins involved in second messenger cascades. ... In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand. ... In animals, the brain or encephalon (Greek for in the head), is the control center of the central nervous system, responsible for behaviour. ... Cholecystokinin (from Greek chole, bile; cysto, sac; kinin, move; hence, move the bile-sac (gall bladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. ...

IUPAC Name: (2S)-2-[[(2S)-2-amino-3-carbamoyl-propanoyl]amino]-N-[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-carbamoyl-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoylmethylcarbamoyl]-2-methyl-propyl]carbamoyl]ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pentanediamide

Sequence: pyr-EQRLGNQWAVGHLM-NH2 Formula: C71 H110 N24 O18 S1 MWmono: 1618.815 MWavg: 1619.853

Image File history File links Size of this preview: 547 × 600 pixelsFull resolution (703 × 771 pixel, file size: 4 KB, MIME type: image/png) Made by me, using WinPLT. October 14, 2006. ... Image File history File links Size of this preview: 547 × 600 pixelsFull resolution (703 × 771 pixel, file size: 4 KB, MIME type: image/png) Made by me, using WinPLT. October 14, 2006. ...

See also


  Results from FactBites:
 
Bombesin (610 words)
Bombesin was described in 1970, as a tetradecapeptide in the skin of frogs (Bombina bombina).
Although Bombesin itself does not exist in mammalian tissue, peptides with structural homology to bombesin (Bombesin Like Peptides) were identified in mammals.
This may mean that the caudal brain stem afferent signals from Bombesin administered in the 4th ventricle are locally integrated, independent of forebrain systems the function of which might be initiation and translation of satiety signals.
  More results at FactBites »


 

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