Please help improve this article or section by expanding it. Further information might be found on the talk page or at requests for expansion.
Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. It was first isolated from bovine cortical bone by Herring [1] it has since been characterized by Fisher and coworkers [2]. Image File history File links Wiki_letter_w. ... Grays Anatomy illustration of a human femur. ... Parts of a tooth, including dentin Dentin (BE: dentine) is the substance between the enamel (substance in the crown) or cementum (substance in the root) of a tooth and the pulp chamber. ... Cementum is a specialized bony substance covering the root of a tooth. ... Cartilage is a type of dense connective tissue. ... Cortical bone is one of two main types of bone. ...
Structure
The initial sequencing of BSP was from a rat cDNA, [3], resulting in a 303 amino acid protein. In genetics, complementary DNA (cDNA) is single-stranded DNA synthesized from a mature mRNA template. ... The general structure of an α-amino acid molecule, with the amine group on the left and the carboxyl group on the right. ...
Function
The amount of BSP in bone and dentin is roughly equal,[4] however the function of BSP in these mineralized tissues is not known. One possibility is that BSP acts as a nucleus for the formation of the first apatite crystals.[5].As the apatite forms along the collagen fibres with in the extracellular matrix, BSP could then help direct, redirect or inhibit the crystal growth. ske| Fracture|| Conchoidal to even Apatite is a group of phosphate minerals, usually referring to hydroxylapatite, fluorapatite, and chlorapatite, named for high concentrations of OH-, F-, or Cl- ions, respectively, in the crystal. ...
References
^ [Herring GM (1972) The organic matrix of bone. In The biochemistry and physiology of bone. Bourne GH, editor. New York: Academic Press, pp127-189.]
^ [Fisher et al. (1983). Matrix sialoprotein of developing bone J Biol Chem 258:12723-12727]
^ [Oldberg A et al (1987) The primary structure of a cell-binding bone sialoprotein. J Biol Chem 263:19430-19432.]
^ Qin C et al. (2001) A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci 109:133-141.
^ Huter GK & Goldberg HA (1994) Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein Biochem J 302:175-179
Bonesialoprotein (BSP) and osteopontin (OPN) are two extracellular bone matrix proteins that have the ability to modulate the growth of hydroxyapatite in vitro.
Bonesialoprotein (BSP) was quantified in synovial fluids and sera from rheumatoid arthritis (RA) patients to elucidate whether its release from bone relates to the degree of joint tissue destruction.
IBSP is a homologue of Ibsp (Bonesialoprotein II precursor) from Mus musculus.
Feeds |
Contact