A miserable stubborn cantankerous old mans, who's actually quite good humoured & an enjoyable compadre to play online alongside if you catch him on a good day.
Bone pain represents one of the most debilitating side effects of the metastases of high-incidence cancers such as breast, prostate, lung, and multiple myeloma (myelomatosis).
A predominant source of bone pain in the cancer patient is due to pathologic fracture and to osteoclast-induced bone resorption by the tumor.
In treatments for bone resorption-induced pain, a group of chemical agents, known as bisphosphonates and calcitonin, acts to strongly block the bone resorption process.
Bone is relatively hard for its density, although it is brittle and may snap on impact, creating what is medically called a fracture.
They are located near to the surface of bone and their functions are to make osteoid and manufacture hormones such as prostaglandin which act on bone itself.
Bone is also the name of a comic book/graphic novel by Jeff Smith in which the Bone Cousins (Fone Bone, Phoney Bone and Smiley Bone) are chased out of their town as a result of a scheme by Phoney Bone and encounter dimwitted quiche-loving rat creatures, taciturn dragons, displaced royalty, and talking bugs.
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