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Whooping cough (pertussis) is caused by the bacterium Bordetellapertussis, B.
The S1 subunit of pertussis toxin is the A component with ADP ribosylating activity, and the function of S2 and S3 is presumed to be involved in binding the intact (extracellular) toxin to its target cell surface.
Thus, pertussis toxin is clearly an important virulence factor in the initial colonization stage of the infection.
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