Bouches-du-Rhône was one of the original 83 departments created during the French Revolution on March 4, 1790. It was created from part of Provence and the principalities of Orange, Martigues, and Lambesc. It lost part of its territory, including Orange and Apt, when the department of Vaucluse was created.
The department is well represented in French art. Paul Cézanne painted numerous representations of the Mont Sainte-Victoire. Vincent van Gogh spent much of his life in Aix-en-Provence, painting many scenes in the area.