Brain natriuretic peptide (also known as B-type natriuretic peptide or "GC-B") is a 32-amino-acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes (heart muscles cells) in the ventricles. At the time of release, a co-secreted 76 amino acid n-terminal fragment (NT-proBNP) is also released with BNP. BNP binds to and activates NPRA in a similar fashion to atrial natriuretic peptide but with 10-fold lower affinity. The biological half-life of BNP however, is twice as long as that of ANP. Both ANP and BNP have limited ability to bind and activate NPRB. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 1 is, by convention, the designation for the largest human chromosome. ... The atrial natriuretic factor receptor is generic term for the natriuretic peptide receptor system which actually consists of at least three isoforms: NPRA, NPRB and NPRC. These receptors bind the Atrial, Brain and C-type natriuretic peptides (ANP, BNP and CNP respectively). ... Atrial natriuretic factor (ANF), atrial natriuretic peptide (ANP) or atriopeptin, is a polypeptide hormone involved in the homeostatic control of body water and sodium. ... The biological halflife of a substance is the time required for half of that substance to be removed from an organism by either a physcial or a chemical process. ...

Tests showing elevated levels of BNP or NT-proBNP in the blood are used as a diagnosis of heart failure and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome.

Both BNP and NT-proBNP have been approved as a marker for acute congestive heart failure (CHF). The plasma concentrations of both BNP are increased in patients with asymptomatic and symptomatic left ventricular dysfunction. Congestive heart failure (CHF), also called congestive cardiac failure (CCF) or just heart failure, is a condition that can result from any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. ...

Brain natriuretic peptide was originally identified in extracts of porcine brain, but in humans it is produced mainly in the cardiac ventricles.

BNP is also marketed as (nesiritide) for the treatment of acute decompensated congestive heart failure. Nesiritide (Natrecor®) is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). ...

References

• Bhatia V, Nayyar P, Dhindsa S (2003). "Brain natriuretic peptide in diagnosis and treatment of heart failure.". J Postgrad Med 49 (2): 182-5. PMID 12867703. Full text.
• Bibbins-Domingo K, Gupta R, Na B, Wu A H B, Schiller N B, Whooley M A (2007). "N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients With Stable Coronary Heart Disease." 297 (2): 169-176. JAMA Abstract.

External links

• MeSH Brain+Natriuretic+Peptide

The normal lab value for BNP is < 100. For patients with CHF, values will be > 100. Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...