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Encyclopedia > Brofaromine

Brofarmine is a psychiatric drug primarily used to treat depression and anxiety. Psychiatry refers to the practice of medicine relating to the mind and behaviour, coming from Greek words meaning healer of the mind. It is a subspecialty of medical practice and is practiced in the United States by people holding the M.D. or D.O. degrees. ... Clinical depression is a state of sadness, melancholia or despair that has advanced to the point of being disruptive to an individuals social functioning and/or activities of daily living. ... Anxiety refers to a complex combination of negative emotions that includes fear, apprehension and worry, and is often accompanied by physical sensations such as palpitations, nausea, chest pain and/or shortness of breath. ...


Pharmacology

Brofarmine is a reversible inhibitor of monoamine oxidase A (RIMA, a type of monoamine oxidase inhibitor (MAOI)) and acts on epinephrine (adrenaline), norepinephrine (noradrenaline), serotonin, and dopamine. Unlike standard MAOIs, possible side effects do not include cardiovascular complications (hypertension) with encephalopathy, liver toxicity or hyperthermia. These drugs, a subset of monoamine oxidase inhibitors (MAOIs), inhibit only isoenzyme A and are reversible. ... Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. ... It has been suggested that this article or section be merged with adrenalin. ... Norepinephrine (INN) or noradrenaline (BAN) is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ... Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. ... Dopamine is a chemical naturally produced in the body. ... The circulatory system or cardiovascular system is the organ system which circulates blood around the body of most animals. ... For other forms of hypertension see hypertension (disambiguation). ... Encephalopathy is a container term for various conditions affecting the brain. ... Hepatotoxicity (from hepatic toxicity) is chemical-driven liver damage. ... Hyperthermia, also known as heat stroke or sunstroke, is an acute condition which occurs when the body produces or absorbs more heat than it can dissipate. ...



  Antidepressants (ATC N06A)  v d e 
Monoamine oxidase inhibitors: {Harmaline} {Nialamide} {Selegiline} {Isocarboxazid} {Iproniazid} {Iproclozide} {Moclobemide} {Brofaromine} {Phenelzine} {Toloxatone} {Tranylcypromine}

Dopamine reuptake inhibitors: {Amineptine} {Methylphenidate} {Phenmetrazine} {Vanoxerine} An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. ... Harmala, also known at various times as Telepathine and Banisterine, is a blanket term for a group of naturally occurring beta-carbolines including harmine, harmaline, and others. ... Nialamide (Espril®, Niamid®, Niaquitil®, Nuredal®, Nyazin®, and Psicodisten®) was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. ... Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinsons disease and senile dementia. ... Isocarboxazid is a nonselective hydrazine-derived monoamine oxidase inhibitor used in treatment resistant depression. ... Iproniazid is a monamine oxidase inhibitor (MAOI) that was developed as the first anti-depressant (Also first psychiatric drug). ... Moclobemide (sold as Aurorix®, Manerix®) is a psychiatric drug primarily used to treat depression and social anxiety. ... Phenelzine (brand name Nardil) is an antidepressant drug that belongs to the monoamine oxidase inhibitor (MAOI) class of drugs. ... Tranylcypromine is an antidepressant drug. ... This article or section does not cite its references or sources. ... Amineptine is an atypical tricyclic antidepressant that selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine, thus exerting a powerful and fast-acting antidepressant effect. ... Methylphenidate (MPH) is an amphetamine-like prescription stimulant commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) in children and adults. ... Phenmetrazine is an amphetamine-like drug. ... Vanoxerine, also known as GBR-12909, is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. ...


Norepinephrine-dopamine reuptake inhibitors: {Bupropion} A Norepinephrine-dopamine reuptake inhibitor is a class of drugs that is both: Dopamine reuptake inhibitor Norepinephrine reuptake inhibitor An example is Bupropion. ... Bupropion (amfebutamone) (brand names Wellbutrin and Zyban) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or selective serotonin reuptake inhibitors (SSRIs). ...


Norepinephrine reuptake inhibitors: {Atomoxetine} {Reboxetine} {Viloxazine} {Maprotiline} Norepinephrine reuptake inhibitors (NRIs) are compounds that increase amounts of the neurotransmitter norepinephrine in the brain by inhibiting its reuptake at synapses. ... Atomoxetine is a drug used in the treatment of attention-deficit hyperactivity disorder (ADHD). ... Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesilate ( methanesulfonate) salt is sold under tradenames including Edronax®, Norebox®, Prolift®, Solvex® or Vestra®. Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. ... Viloxazine is a bicyclic antidepressants[2] that inhibits the reuptake of serotonin, and to a lesser extent, dopamine and norepinephrine. ... To meet Wikipedias quality standards, this article may require cleanup. ...


Serotonin-norepinephrine reuptake inhibitors: {Desipramine} {Duloxetine} {Milnacipran} {Nefazodone} {Venlafaxine} Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders. ... Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. ... Duloxetine hydrochloride (brand names: Cymbalta/Yentreve) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). ... Milnacipran is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. ... // Introduction Serzone (nefazodone) Serzone ( Nefazodone HCl ) is an antidepressant drug formerly marketed by Bristol-Myers Squibb. ... Venlafaxine hydrochloride is a prescription antidepressant first introduced by Wyeth in 1993. ...


Selective serotonin reuptake inhibitors: {Alaproclate} {Etoperidone} {Citalopram} {Escitalopram} {Fluoxetine} {Fluvoxamine} {Paroxetine} {Sertraline} {Zimelidine} Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants for treating depression, anxiety disorders and some personality disorders. ... Alaproclate is an antidepressant that increases serotonin levels by inhibiting the uptake of 5-HT. Today, its primarily used to stagment the cravings for cocaine. ... Citalopram or nitalapram is an antidepressant drug used to treat the depression associated with mood disorders. ... Escitalopram is a medication developed by the Danish pharmaceutical company Lundbeck, that acts as a selective serotonin reuptake inhibitor or SSRI. It is typically used as an antidepressant to treat depression associated with mood disorders although also may be used in the treatment of body dysmorphic disorder and anxiety. ... Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. ... Fluvoxamine maleate (sold under the brand-names Luvox® and Faverin®) is a selective serotonin reuptake inhibitor. ... Paroxetine or paroxetine hydrochloride (sold as Paxil in the United States, Canada and Brazil; Seroxat in Austria, Greece, Poland, Portugal, the UK and China; Aropax in Australia, New Zealand, South Africa and Brazil; Pondera in Brazil; Deroxat in Switzerland and France; Paroxat in Germany, and Cebrilin in Latin America) is... Sertraline hydrochloride (Zoloft®, Sertralin®, Lustral®, Apo-Sertral®, Asentra®, Gladem®, Serlift®, Stimuloton®, Xydep®, Serlain®, Concorz®) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. ... // General Remars and History Zimelidine is a pyridylallylamine and has a structure different from other antidepressants. ...


Selective serotonin reuptake enhancers: {Tianeptine} Tianeptine (INN) (Stablon®, Coaxil®, Tatinol®), is structurally similar to the tricyclic antidepressants. ... Tianeptine (INN) (Stablon®, Coaxil®, Tatinol®), is an SSRE, or Selective Serotonin Reuptake Enhancer, structurally similar to the tricyclic antidepressants. ...


Tricyclic antidepressants: {Amitriptyline} {Butriptyline} {Clomipramine} {Desipramine} {Dothiepin} {Doxepin} {Imipramine} {Lofepramine} {Nortriptyline} {Protriptyline} {Trimipramine} {Iprindole} {Opipramol} Chemical structure of the tricyclic antidepressant amitriptyline Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. ... Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®. It is a white, odorless, crystalline compound which is freely soluble in water. ... Clomipramine (brand-name Anafranil®) is a tricyclic antidepressant. ... Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. ... dothiepin hydrochloride ... Doxepin is a tricyclic antidepressant, known under many brand-names such as Aponal®, the original preparation by Boehringer-Ingelheim, now part of the Roche group; Adapine®, Sinquan® and Sinequan® (Pfizer Inc. ... Imipramine (tradenames: Janimine®, Tofranil®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis. ... Nortriptyline is a tricyclic antidepressant marketed under the tradenames Aventyl® and Pamelor®. It is used to treat depression. ... Trimipramine is an tricyclic antidepressant with sedative and anxiolytic properties. ...


Tetracyclic antidepressants: {Maprotiline} {Mianserin} {Mirtazapine} {Amoxapine} {Trazodone} {Nefazodone} The structure of the tetracyclic antidepressant mirtazapine A tetracyclic antidepressant is an antidepressant drug from the tetracyclic drug group. ... To meet Wikipedias quality standards, this article may require cleanup. ... Mianserin is a tetracyclic antidepressant that has an antihistaminic and hypnosedative, but almost no anticholinergic effect. ... Mirtazapine is a prescription antidepressant introduced by Organon International in 1996. ... Amoxapine (Asendin®; Asendis®; Defanyl®; Demolox®; Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. ... Trazodone (Desyrel®, Trittico®, Thombran®, Trialodine®) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. ... // Introduction Serzone (nefazodone) Serzone ( Nefazodone HCl ) is an antidepressant drug formerly marketed by Bristol-Myers Squibb. ...


  Results from FactBites:
 
Meta-Analysis of the Reversible Inhibitors of Monoamine Oxidase Type A Moclobemide and Brofaromine for the Treatment ... (8974 words)
Brofaromine [4-(5-methoxy-7-bromo-benzofuranyl)-2- piperidine HCL] was first synthesized in the early 1980s, and its potential as an antidepressant was rapidly appreciated (e.g., Waldmeier et al.
Brofaromine was found to be significantly more effective than placebo on several outcome measures, but not on the Hamilton Scale, the principal a priori outcome measure.
Brofaromine was also generally better tolerated than the combination of maprotiline and lithium, although complaints about sleep problems were again higher in the BRO group (Hoencamp et al.
Brofaromine ( Consonar ) (229 words)
A multicenter, double-blind, placebo-controlled study including 220 patients was undertaken to evaluate the efficacy and safety of brofaromine in major depression.
In comparative controlled studies (n = 899), brofaromine was found to be at least as efficacious as tricyclic antidepressants (imipramine) and standard MAOIs (tranylcypromine and phenelzine).
Brofaromine also was found to be of comparable efficacy to tranylcypromine in two clinical trials (n = 132), one of which included patients considered to have a treatment-resistant depression (n = 39).
  More results at FactBites »


 
 

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