Bromocriptine is an ergoline derivative dopamineagonist that is used in the treatment of pituitarytumors and Parkinson's disease. Chemical structure of ergoline Ergoline is a chemical compound whose structure serves as the skeleton for a diverse range of alkaloids and synthetic drugs. ... Jump to: navigation, search Dopamine is a chemical naturally produced in the body. ... Agonists An agonist is a substance that binds to a receptor and triggers a response in the cell. ... Located at the base of the skull, the pituitary gland is protected by a bony structure called the sella turcica. ... Tumor (American English) or tumour (British English) originally means swelling, and is sometimes still used with that meaning. ...
Amenorrhea, female infertility, galactorrhea, hypogonadism, and acromegaly may all be caused by pituitary problems an therfore may be treated by this drug. It is also used following stillbirth to suppress the mother's production of breast milk as that may add to her distress. Amenorrhoea (BE) or amenorrhea (AmE) is the absence of a menstrual period in a woman of reproductive age. ... Infertility is the inability to naturally conceive a child or the inability to carry a pregnancy to term. ... Galactorrhea or galactorrhoea is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing. ... Hypogonadism is a medical term for a defect of the reproductive system which results in lack of function of the gonads (ovaries or testes). ... Acromegaly (from Greek akros high and megalos large - extremities enlargement) is a hormonal disorder that results when the pituitary gland produces excess growth hormone (hGH). ... Jump to: navigation, search Stillbirth is when pregnancy ends without a live birth due to natural causes, including pregnancy loss, miscarriage, or spontaneous abortion. ...
Because of its effects as a dopamineagonist, bromocriptine has potential use in treating addiction to cocaine, a drug that exhibits its own effects by blocking dopamine reuptake.
Bromocriptine antagonizes behavioral effects of cocaine in the rat.
Bromocriptine was originally approved by the FDA in 1978 for the treatment of amenorrhea/galactorrhea secondary to hyperprolactinemia and was subsequently approved for infertility (1981), acromegaly (1984), prolactin-secreting pituitary adenomas (1985).
Bromocriptine is contraindicated in patients with eclampsia or toxemia of pregnancy.
Bromocriptine is contraindicated in patients with ergot alkaloid hypersensitivity.