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Encyclopedia > Budesonide
Budesonide
Systematic (IUPAC) name
16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11-β,16-α)-pregna-1,4-diene-3,20-dione
Identifiers
CAS number 51333-22-3
ATC code A07EA06 D07AC09, R01AD05, R03BA02
PubChem 63006
DrugBank APRD00442
Chemical data
Formula C25H34O6 
Mol. mass 430.534 g/mol
Pharmacokinetic data
Bioavailability 100% (but large first pass effect)
Protein binding 85-90%
Metabolism Hepatic CYP3A4
Half life 2.0-3.6 hours
Excretion Renal, Faecal
Therapeutic considerations
Pregnancy cat.

C(US) Image File history File links No higher resolution available. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism A07A Intestinal anti-infectives A07AA Antibiotics A07AA01 Neomycin A07AA02 Nystatin A07AA03 Natamycin A07AA04 Streptomycin A07AA05 Polymyxin B A07AA06 Paromomycin A07AA07 Amphotericin B A07AA08 Kanamycin A07AA09 Vancomycin A07AA10 Colistin A07AA11 Rifaximin A07AA51 Neomycin, combinations A07AA54 Streptomycin, combinations... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... This article or section does not cite any references or sources. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... A drugs efficacy may be affected by the degree to which it binds to the proteins within blood plasma. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

POM(UK) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained. ...

Routes Oral, Nasal, tracheal, rectal

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. Additionally, it is used for inflammatory bowel disease. It is marketed by AstraZeneca as a nasal inhalation with the brand name Rhinocort (in Denmark, as Rhinosol), as an oral inhalation with the brand name Pulmicort, and as an enema and a modified-release capsule with the brand name Entocort. It is also sold in combination with formoterol (Oxis) in a single inhaler, with the brand name Symbicort. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... Steroid skeleton of lanosterol. ... Rhinitis is the medical term describing irritation and inflammation of the nose. ... For the play, see Hay Fever. ... In medicine, inflammatory bowel disease (IBD) is a group of inflammatory conditions of the large intestine and, in some cases, the small intestine. ... AstraZeneca PLC (LSE: AZN, NYSE: AZN), is a large Anglo-Swedish pharmaceutical company formed on 6 April 1999 by the merger of Swedish Astra AB and British Zeneca Group. ... (adj. ... Formoterol belongs to the family of prescription-only medicines known as beta 2-agonists. ... Symbicort is an inhaled treatment for asthma and COPD, marketed by AstraZeneca. ...

Contents

Pharmacology

Budesonide has a high first pass metabolism. It has efficacy in the terminal ileum and the right colon. Budesonide in comparison with prednisolone has been associated with fewer bone density losses and unlike other corticosteroids has little influence on the hypothalamic-pituitary-adrenal axis which also limit the need of tapering before discontinuation. Overall, it has a lower incidence of systemic manifestations than similar medications. A few of the metabolic pathways in a cell. ... Grays Fig. ... Colon has several meanings: colon (anatomy) colon (punctuation) colon (rhetoric) See also Colón This is a disambiguation page — a navigational aid which lists other pages that might otherwise share the same title. ...


Side Effects

Budesonide may cause:

  • nose irritation or burning
  • bleeding or sores in the nose
  • lightheadedness
  • upset stomach
  • cough
  • hoarseness
  • dry mouth

In addition the following should be reported:

  • Immediately if difficulty breathing or swelling of the face
  • white patches in the throat, mouth, or nose
  • irregular menstrual periods
  • severe acne

Recall

Pulmicort inhalers were recalled in 2002 because there was concern that they may not always have provided the full dosage.


External links

  • FDA Label (PDF)
  • National Institute of Health's Medline about Budesonide
  • Entocortec: capsule form; treats Crohn's Disease
  • Rhinocort Aqua: spray form; treats nasal symptoms
  • [1]: Pulmicort Recall
  • [2]: Pulmicort Respules
  • Side Effects of Budesonide
v • d • e
Medications commonly used in asthma and COPD (primarily R03)
Anticholinergics Ipratropium • Tiotropium
Short acting β2-agonists Salbutamol • Fenoterol • Terbutaline
Long acting β2-agonists (LABA) Bambuterol • Clenbuterol • Formoterol • Salmeterol
Corticosteroids Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Leukotriene antagonists Montelukast • Pranlukast • Zafirlukast
Xanthines Aminophylline • Theobromine • Theophylline
Mast cell stabilizers Cromoglicate • Nedocromil
Combination products Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol
v • d • e
Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor (A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
Endogenous Aldosterone, Cortisone, Hydrocortisone/cortisol, Desoxycortone
Others Alclometasone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone,Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone, Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol

  Results from FactBites:
 
Rhinocort Online, Description, Chemistry, Ingredients - Budesonide - RxList Monographs (259 words)
Budesonide is provided as the mixture of two epimers (22R and 22S).
Budesonide is a white to off-white, odorless powder that is practically insoluble in water and in heptane, sparingly soluble in ethanol, and freely soluble in chloroform.
RHINOCORT AQUA is an unscented, metered-dose, manual-pump spray formulation containing a micronized suspension of budesonide in an aqueous medium.
Budesonide (Entocort EC) (460 words)
Oral budesonide is FDA-labeled for the treatment of mild to moderately active Crohn's disease involving the ileum and/or the ascending colon.
Budesonide capsules are enteric coated (dissolution at pH >5.5) and contain a ethylcellulose matrix to allow for sustained release in the ileum and ascending colon.
Administration of budesonide with inhibitors substantially increased budesonide serum concentrations and increased the incidence of hypercorticism.
  More results at FactBites »


 
 

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