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Encyclopedia > C3 (complement)
complement component 3
Identifiers
Symbol C3
HUGO 1318
Entrez 718
OMIM 120700
RefSeq NM_000064
UniProt P01024
Other data
EC number 3.4.21.43
Locus Chr. 19 p13.3-13.2

In immunology, soluble C3-convertase, also known as iC3Bb, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the alternative complement system. C3b may then bind to microbal cell surfaces within an organisms body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound. Alternatively, bound C3b may aid in opsonization of the microbe by macrophages. Complement receptor 1 or CR1 on macrophages allows the engaging of C3b covered microbes. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... Short and long arms Chromosome. ... Chromosome 19 is one of the 23 pairs of chromosomes in humans. ... C3-convertase is the name of the enzyme composed of the C4b-C2b complex, which forms during the Classical pathyway of the complement system. ... Proteolysis is the directed degradation (digestion) of proteins by cellular enzymes called proteases or by intramolecular digestion. ... A complement protein attacking an invader. ... A microorganism or microbe is an organism that is so small that it is microscopic (invisible to the naked eye). ... An opsonin is any molecule that acts as a binding enhancer for the process of phagocytosis. ... Macrophages (Greek: big eaters) are cells found in tissues that are responsible for phagocytosis of pathogens, dead cells and cellular debris. ... Complement receptor 1 Also known as CR1, CD35, C3b/C4b receptor and immune adherence receptor. ...


See also

A complement protein attacking an invader. ...

External links

  • Structure and biology of complement protein C3, a connecting link between innate and acquired immunity; Recent review article
  • domain structure; protein database
  • complete structure; protein database
  • complete structure; protein database
  • The Structure of Bovine Complement Component 3 Reveals the Basis for Thioester Function; Structure Article
v • d • e
Proteins: complement system

Activators: C6 - C7 - C9 - MBL2 - PFC
Complexes: C1Q (C1QA, C1QB, C1QG) - C3-convertase - C8 (C8A, C8B, C8G) - MAC
Enzymes: BF - C1R - C1S - C2 - C3 - C4 - C5 - DF - MASP1 - MASP2
Inhibitors: C1inh - C4BP (C4BPA, C4BPB) - CLU - DAF - HF1 - IF - SERPING1 - VTN
Complement receptors: C3AR1 - C5R1 - CR1 - CR2 - ITGAM - CD46 A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... A complement protein attacking an invader. ... Complement component 6 is a protein involved in the complement system. ... Complement component 7 is a protein involved in the complement system. ... Complement component 9 is a protein involved in the complement system. ... MBL2 is a protein involved in the complement system. ... PFC is a protein involved in the complement system. ... The C1q complex is potentially multivalent for attachment to the complement fixation sites of immunoglobulin. ... Complement component 1QA is a protein involved in the complement system. ... Complement component 1QB is a protein involved in the complement system. ... Complement component 1QG is a protein involved in the complement system. ... C3-convertase is the name of the enzyme composed of the C4b-C2b complex, which forms during the Classical pathyway of the complement system. ... Complement component 8A is a protein involved in the complement system. ... Complement component 8B is a protein involved in the complement system. ... Complement component 8G is a protein involved in the complement system. ... MAC is also called the killer molecule. ... BF is a protein involved in the complement system. ... Complement component 1R is a protein involved in the complement system. ... Complement component 1S is a protein involved in the complement system. ... Complement component 2 is a protein involved in the complement system. ... Complement component 4 is a protein involved in the complement system. ... Complement component 5 is a protein involved in the complement system. ... DF is a protein involved in the complement system. ... MASP1 is a protein involved in the complement system. ... MASP2 is a protein involved in the complement system. ... C1-inhibitor (C1inh) is a serine protease inhibitor (serpin) protein, the main function of which is inhibition of the complement system. ... C4BP (Complement C4B-binding protein) can refer to: C4BPA (protein) C4BPB (protein) Category: ... C4BPA is a protein involved in the complement system. ... C4BPB is a protein involved in the complement system. ... CLU is a protein involved in the complement system. ... Decay accelerating factor is a protein involved in the complement system. ... HF1 is a protein involved in the complement system. ... IF is a protein involved in the complement system. ... SERPING1 is a protein involved in the complement system. ... Vitronectin is an abundant glycoprotein found in blood plasma and the extra cellular matrix. ... A Complement receptor is a receptor of the complement system, a part of the mediated innate immune system. ... C3AR1 is a protein involved in the complement system. ... C5R1 is a protein involved in the complement system. ... Complement receptor 1 Also known as CR1, CD35, C3b/C4b receptor and immune adherence receptor. ... Complement component receptor 2 is a protein involved in the complement system. ... Integrin alpha M is a protein involved in the complement system. ... CD46 is an inhibitory complement receptor. ...



 
 

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