Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. ^[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.^[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... Short and long arms Chromosome. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... A glycoprotein is a macromolecule composed of a protein and a carbohydrate (an oligosaccharide). ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... Monocyte A monocyte is a leukocyte, part of the human bodys immune system that protect against blood-borne pathogens and move quickly to sites of infection in the tissues. ... Natural killer cells (NK) are a type of lymphocyte (a white blood cell) and a component of nonspecific immune defense. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ...

References

1. ^ Miller and Krangel. The Human Cytokine I-309 is a Monocyte Chemoattractant. Proceedings of the National Academy of Sciences, 1992, Vol 89, 2950-2954.
2. ^ Roos et al., Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem 1997 Vol 272, 17251–4.