Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been decribed in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.^[1] This chemokine is found predomiantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.^[1][2] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.^[2] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... Eosinophils are white blood cells that are responsible for combating infection by parasites in the body. ... Monocyte A monocyte is a leukocyte, part of the human bodys immune system that protect against blood-borne pathogens and move quickly to sites of infection in the tissues. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Lymph nodes are components of the lymphatic system. ... In human anatomy, the thymus is an organ located in the upper anterior portion of the chest cavity. ... This article needs cleanup. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ... For other meanings of this term, see gene (disambiguation). ... THERE ARE NOW 30 CHROMOSOMES!!!!!! Figure 1: A representation of a condensed eukaryotic chromosome, as seen during cell division. ...

References

1. ^ ^{a b} Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med 184 (5): 1939-51. PMID 8920881. 
2. ^ ^{a b} Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med 185 (1): 99-109. PMID 8996246.