Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.^[1]. CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5.^[2] Activity of this chemokine has been implicated in allergic reactions such as asthma.^[3] CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... For other meanings of this term, see gene (disambiguation). ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Monocyte A monocyte is a leukocyte, part of the human bodys immune system that protect against blood-borne pathogens and move quickly to sites of infection in the tissues. ... Eosinophils are white blood cells that are responsible for combating infection by parasites in the body. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Categories: Wikipedia cleanup | Biology stubs | Blood and immune system cells ... Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. ... This article needs cleanup. ... Interleukin-1 (IL-1) is a cytokine that is secreted by macrophages, monocytes and dendritic cells. ... In medicine, tumor necrosis factor alpha (TNFα, cachexin or cachectin) is an important cytokine involved in systemic inflammation and the acute phase response. ...

References

1. ^ Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
2. ^ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
3. ^ Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.