Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus and spleen and is chemoattractive for monocytes and lymphocytes.^[1] Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-γ and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines.^[2] CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.^[3][4] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... A pseudonym (Greek pseudo + -onym: false name) is an artificial, fictitious name, also known as an alias, used by an individual as an alternative to a persons true name. ... The liver is an organ in some animals, including vertebrates (and therefore humans). ... In human anatomy, the thymus is an organ located in the upper anterior portion of the chest cavity. ... The spleen is an organ of the upper abdomen, where it functions in the destruction of old red blood cells and holding a reservoir of blood. ... Monocyte A monocyte is a leukocyte, part of the human bodys immune system that protect against blood-borne pathogens and move quickly to sites of infection in the tissues. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Ilyushin Il-10 was a ground attack aircraft that was an upgrade from the Ilyushin Il-2 developed past the second world war. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... A lipopolysaccharide (LPS) is any of a class of large molecules consisting of a lipid and a polysaccharide (carbohydrate) joined by a covalent bond. ... For other meanings of this term, see gene (disambiguation). ... Chromosome 17 is one of the 23 pairs of chromosomes in humans. ...

References

1. ^ Youn et al. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem. Biophys. Res. Commun. 247:217-222 (1998).
2. ^ Nomiyama et al. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. J. Interferon Cytokine Res. 19:227-234 (1999).
3. ^ Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
4. ^ Howard et al. LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. Blood. 2000 Aug 1;96(3):840-5.