Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.^[1] The gene for CCL19 is located on human chromosome 9.^[2]. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.^[1] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells.^[3][4] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 9 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... In human anatomy, the thymus is an organ located in the upper anterior portion of the chest cavity. ... Lymph nodes are components of the lymphatic system. ... Look up trachea in Wiktionary, the free dictionary. ... Colon has several meanings: colon (anatomy) colon (punctuation) colon (rhetoric) See also Colón This is a disambiguation page — a navigational aid which lists other pages that might otherwise share the same title. ... In biology the small intestine is the part of the gastrointestinal tract (gut) between the stomach and the large intestine. ... Respiratory system The lungs flank the heart and great vessels in the chest cavity. ... It has been suggested that Renal anomalies and Renal plasma threshold be merged into this article or section. ... The spleen is an organ of the upper abdomen, where it functions in the destruction of old red blood cells and holding a reservoir of blood. ... Chromosome 9 is one of the 23 pairs of chromosomes in humans. ... Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ...

References

1. ^ ^{a b} Yoshida et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-13809, 1997.
2. ^ Rossi et al. Identification through bioinformatics of two new macrophage proinflammatory human chemokines. J. Immun. 158: 1033-1036, 1997.
3. ^ Robbiani et al. The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3-beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103: 757-768, 2000.
4. ^ Reif et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416: 94-99, 2002.