Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.^[1] CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.^[2] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... Short and long arms Chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Neutrophil granulocytes (commonly referred to as neutrophils) are a class of white blood cells and are part of the immune system. ... The mucous membranes (or mucosae; singular: mucosa) are linings of ectodermic origin, covered in epithelium, and are involved in absorption and secretion. ... In mammals including humans, the lymphatic vessels (or lymphatics) are a network of thin tubes that branch, like blood vessels, into tissues throughout the body. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... In zootomy, epithelium is a tissue composed of a layer of cells. ... Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. ...

Gene expression of CCL20 can be induced by microbial factors such as lipopolysaccharide (LPS), and inflammatory cytokines such as tumor necrosis factor and interferon-γ, and down-regulated by IL-10.^[3] CCL20 is expressed in several tissues with highest expression observed in peripheral blood lymphocytes, lymph nodes, liver, appendix, and fetal lung and lower levels in thymus, testis, prostate and gut.^[1][4] The gene for CCL20 (scya20) is located on chromosome 2 in humans.^[5] For other meanings of this term, see gene (disambiguation). ... A microorganism or microbe is an organism that is so small that it is microscopic (invisible to the naked eye). ... A lipopolysaccharide (LPS) is any of a class of large molecules consisting of a lipid and a polysaccharide (carbohydrate) joined by a covalent bond. ... In medicine, tumor necrosis factor alpha (TNFα, cachexin or cachectin) is an important cytokine involved in systemic inflammation and the acute phase response. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... Ilyushin Il-10 was a ground attack aircraft that was an upgrade from the Ilyushin Il-2 developed past the second world war. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Lymph nodes are components of the lymphatic system. ... The liver is an organ in some animals, including vertebrates (and therefore humans). ... Appendix can mean: Appendix (see Book design), part of the content of some books vermiform appendix, a human internal organ, physically part of the digestive system but which function is a matter of controversy See also Look up appendix in Wiktionary, the free dictionary. ... A human fetus A fetus (or foetus, or fÅ“tus – see below) is a developing mammal after the embryonic stage and before birth. ... Respiratory system The lungs flank the heart and great vessels in the chest cavity. ...

References

1. ^ ^{a b} Hieshima et al., Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J. Biol. Chem., 1997, 272:5846-5853.
2. ^ Baba et al., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997, 272:14893-8.
3. ^ Schutyser et al., Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. J. Immunol., 2000, 165:4470-4477.
4. ^ Rossi et al., Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J. Immunol., 1997, 158:1033-1036.
5. ^ Nelson et al., Genomic organization of the CC chemokine mip-3alpha/CCL20/larc/ exodus/SCYA20, showing gene structure, splice variants, and chromosome localization. Genomics, 2001, 73:28-37.