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Encyclopedia > CCL9
chemokine (C-C motif) ligand 9
Symbol(s): CCL9 SCYB9, CCL10, MIP-1gamma, CCF18, MRP-2
Database Links
Entrez: 20308
RefSeq: NM_011338
UniProt: P51670

Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18 , that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1.[1] CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting a important role for CCL9 in bone resorption.[2] CCL9 is constitutively expressed in macrophages and myeloid cells.[3][4] The gene for CCL9 is located on chromosome 11 in mice.[4] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... In botany, a follicle is a type of simple dry fruit produced by certain flowering plants. ... Types of epithelium This article discusses the epithelium, an animal anatomical structure. ... Peyers patches are secondary lymphoid organs named after the 17th-century Swiss anatomist Hans Conrad Peyer. ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... Integrin alpha M is a protein involved in the complement system. ... Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic DRY motif in the second intracellular domain. ... An osteoclast (from the Greek words for bone and broken) is a type of bone cell that removes bone tissue by removing the bones mineralized matrix. ... Bone resorption is the process by which osteoclasts break down bone and release the minerals. ... A macrophage of a mouse stretching its arms to engulf two particles, possibly pathogens Macrophages (Greek: big eaters, makros = long, phagein = eat) are white blood cells, more specifically phagocytes, acting in the nonspecific defense as well as the specific defense system of vertebrate animals. ... Myeloid cells is a subsummating term for all hemopoietic cells except the lymphoid ones (T-cells, B-cells, NK-cells, dendritic cells). ... For other meanings of this term, see gene (disambiguation). ... THERE ARE NOW 30 CHROMOSOMES!!!!!! Figure 1: A representation of a condensed eukaryotic chromosome, as seen during cell division. ...


References

  1. ^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A (2003). "CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells". J Immunol 171 (6): 2797-803. PMID 12960300. 
  2. ^ Lean J, Murphy C, Fuller K, Chambers T (2002). "CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts". J Cell Biochem 87 (4): 386-93. PMID 12397598. 
  3. ^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B (1995). "A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors". J Immunol 155 (5): 2661-7. PMID 7650394. 
  4. ^ a b Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A (1995). "Molecular cloning and functional characterization of a novel member of the C-C chemokine family". J Immunol 155 (11): 5352-8. PMID 7594550. 


 
 

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