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This CD molecule is the membrane receptor for stem cell factor (SCF), also known as "steel factor" or "c-kit ligand". Steel factor is a polypeptide that activates bone marrow precursors of a number of blood cells, but its receptor is also present on other cells. C-kit mutations in the interstitial cells of Cajal in the digestive tract are probably the key to gastrointestinal stromal tumors (GISTs), and explain the efficacy of imatinib in the management of these rare malignancies. Hugo is a masculine name. ...
The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ...
The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ...
The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ...
Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ...
Short and long arms Chromosome. ...
Chromosome 4 is one of the 23 pairs of chromosomes in humans. ...
The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ...
In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm that binds to a specific factor (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand. ...
Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ...
Grays Anatomy illustration of cells in bone marrow. ...
A blood cell is any cell of any type normally found in blood. ...
Interstitial cells of Cajal are found in the Gastrointestinal tract ICC:s have an unstable membrane potential (between -65 and -45mV), forming a sort of pacemaker. ...
For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and...
Endoscopic image of GIST in fundus of stomach, seen on retroflexion. ...
Imatinib is a drug used to treat certain types of cancer. ...
A rare disease (sometimes known as an orphan disease) has such a low prevalence in a population that a doctor in a busy general practice would not expect to see more than one case a year. ...
Cluster of differentiation (CD) molecules are markers on the cell surface, as recognized by specific sets of antibodies, used to identify the cell type, stage of differentiation and activity of a cell. The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ...
See also
Tyrosine kinases are a subclass of protein kinase, see there for the principles of protein phosphorylation A tyrosine kinase (EC 2. ...
External links - MeSH Proto-Oncogene+Proteins+c-kit
Adenylate - Creatine - Gluco- - Hexo- - Nucleoside-diphosphate - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Phosphofructo- - Pyruvate - Thymidine Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...
In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group (e. ...
In biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation. ...
Adenylate kinase (also known as ADK) is a phosphotransferase enzyme (EC 2. ...
Creatine Kinase Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2. ...
Glucokinase Glucokinase (EC 2. ...
A hexokinase is an enzyme that phosphorylates a six-carbon sugar, a hexose, to a hexose phosphate. ...
Phosphoinositide 3-kinases (PI 3-kinases or PI3Ks) are a family of related enzymes that are capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns)[1]. The various 3-phosphorylated phosphoinositides that are produced by PI 3-kinases (PtdIns3P, PtdIns(3,4)P2, PtdIns...
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. ...
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation. ...
Phosphofructokinase (PFK) is the most important regulatory enzyme (EC 2. ...
Pyruvate kinase is an enzyme involved in glycolysis. ...
Thymidine kinase TK, is an enzyme, a phosphotransferase (a kinase): 2-deoxythymidine kinase, ATP-thymidine 5-phosphotransferase, {{{EC 2. ...
protein kinases A protein kinase is an enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). ...
Serine/threonine-specific: AMP-activated - Aurora - C - c-Raf - Calmodulin/Calmodulin dependent/Ca2+/calmodulin-dependent - CAMP-dependent (Beta adrenergic receptor) - Cyclin-dependent - EIF-2 kinase - Mammalian target of rapamycin - Mitogen-activated/MAP2K (Extracellular signal-regulated, C-Jun N-terminal, P38 mitogen-activated protein) - Myosin light-chain - Phosphorylase serine threonine phosphate Serine/threonine protein kinases (EC 2. ...
5AMP-activated protein kinase or AMPK consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans, that plays a role in cellular energy homeostasis. ...
Aurora Kinases are serine/threonine kinases that are essential for cell proliferation. ...
A protein kinase is an enzyme that can transfer a phosphate group from a donor molecule (usually ATP) to an amino acid residue of a protein. ...
c-raf is gene that codes for a protein kinase. ...
Calmodulin kinase (Camk) is a kinase enzyme. ...
Calmodulin dependent kinase (Camk) is a kinase enzyme. ...
In cell biology, cAMP-dependent protein kinase (cAPK), also known as protein kinase A (PKA, EC 2. ...
// Upon stimulation of the B-adrenergic receptor by epinephrine, Gs will be activated. ...
Cyclin-dependent kinases (CDK) belong to a group of protein kinases originally discovered as being involved in the regulation of the cell cycle. ...
The mammalian target of rapamycin is commonly known as mTOR. It is a serine/threonine kinase that regulates translation and cell division. ...
In cell biology, mitogen-activated protein kinases (MAPKs) are serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as gene expression, mitosis, differentiation, and cell survival/apoptosis. ...
Extracellular signal-regulated kinases (ERKs) are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. ...
C-Jun N-terminal kinases (JNKs), originally identified as kinases that bind and phosphosphorylate c-Jun on Ser63 and Ser73 within its transcriptional activation domain, are mitogen-activated protein kinases which are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in...
Phosphorylase kinase is a serine/threonine-specific protein kinase which converts phosphorylase b to Phosphorylase a. ...
Tyrosine: Abelson leukemia virus protein - CD117 - C-MET - Receptor tyrosine kinase - Janus kinase - Src (Lck) - Syk - ZAP-70 Tyrosine kinases are a subclass of protein kinase, see there for the principles of protein phosphorylation A tyrosine kinase (EC 2. ...
Abl (Abelson leukemia virus protein, chromosome 9q34) is an important tyrosine kinase. ...
c-MET is a pro-oncogene. ...
The receptor tyrosine kinase (RTK) family of cell surface receptors shows a high affinity to numerous growth signals. ...
Janus kinase (JAK) is a family of intracellular tyrosine kinases, ranging from 120-140 kDa, that are involved in the JAK-STAT pathway. ...
Src is a family of proto-oncogenes that may lead to cancer. ...
Rickenbacker International Airport (airport code: LCK) is located in Columbus, Ohio. ...
CD1 - CD2 - CD3 - CD4 - CD8 - CD11 - CD14 - CD15 - CD19 - CD20 - CD23 - CD28 - CD31 - CD32 - CD34 - CD35 - CD36 - CD38 - CD40 - CD44 - CD45 - CD56 - CD72 - CD80 - CD86 - CD90 - CD98 - CD117 - CD134 - CD141 - CD142 - CD152 - CD154 - CD155 - CD209 - CD278 The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ...
CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. ...
In immunology, the CD3 antigen (CD stands for cluster of differentiation) is a protein complex composed of three distinct chains (CD3γ, CD3δ and CD3ε) in mammals, that associate with molecules known as the T cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. ...
CD4 (cluster of differentiation 4) is a molecule that is expressed on the surface of T helper cells (as well as regulatory T cells and dendritic cells). ...
CD8 (cluster of differentiation 8) is a molecule that is expressed on the surface of cytotoxic T cells. ...
CDC11c is a type I transmembrane protein found on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. ...
CD14 is a membrane-associated glycosylphosphatidylinositol-linked protein expressed at the surface of cells, especially macrophages. ...
CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells. ...
CD23 or Fc epsilon RII is the low affinty receptor for IgE, an antibody isotype involved in allergy and (arguably) resistance to parasites and is important in regulation of IgE levels. ...
Structure of human CD28. ...
CD31 is a cluster of differentiation molecule. ...
The CD32 in action The AmigaCD32 was the worlds first 32bit CD_ROM based game console. ...
CD34 is a cluster of differentiation molecule present on certain cells within the human body. ...
Complement receptor 1 Also known as CR1, CD35, C3b/C4b receptor and immune adherence receptor. ...
CD36 CD36 (GP88) is an 88-kDa cell surface single polypeptide chain glycoprotein, preferentially located within lipid rafts, which is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, liver and spleen cells and some skin microdermal endothelial cells. ...
CD38 (cluster of differentiation 38) is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. ...
In immunology, the CD45 antigen (CD stands for cluster of differentiation) is a protein which is a leucocyte common antigen, a type I transmembrane protein present on all differentiated hematopoietic cells except erythrocytes that assists in the activation of those cells (a form of co-stimulation). ...
Neural Cell Adhesion Molecule (NCAM) is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. ...
CD72, also known in murine biology as Lyb-2, is a protein active in the immune system of animals. ...
The protein CD80 is a molecule which provides a costimulatory signal necessary for T cell activation and survival. ...
The protein CD86 is a molecule which provides a costimulatory signal necessary for T cell activation and survival. ...
Thrombomodulin is an integral membrane protein expressed on the surface of epithelial cells. ...
Thromboplastin is a substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in coagulation of blood. ...
CTLA-4 (Cytotoxic T-lymphocyte antigen-4) is a CD28-family receptor expressed on mainly CD4+ T cells. ...
CD154, also called CD40 ligand or CD40L, is a protein that is expressed on T cell surfaces. ...
DC-SIGN or CD209 is a C-type lectin receptor present mainly on myeloid and pre-plasmacytoid dendritic cells that mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens. ...
List of Human Clusters of Differentiation The following is a list of Clusters of Differentiation (or CD) molecules. ...
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