The protein CD86 is a molecule which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.2. Its principal mode of action is by binding to CD28. Along with CD80, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 3 is one of the 23 pairs of chromosomes in humans. ... Structure of human CD28. ... The protein CD80 is a molecule which provides a costimulatory signal necessary for T cell activation and survival. ...