1. Corticotropin-releasing hormone Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response. ...
2. The Irish building material group CRH plc (formerly Cement-Roadstone Holdings plc). CRH plc, (ISE: CRH) , (LSE: CRH) , (NYSE: CRHCY), (Xetra: CRH) , is an Irish building material group, formerly called Cement-Roadstone Holdings plc. ...
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CRH is a 41-amino acid peptide, which shows considerable interspecies homology at the amino terminal region and acts as the major physiologic ACTH secretagogue (4,5).
CRH is synthesized by neurons of the parvocellular hypothalamic paraventricular nuclei (9) and is secreted -along with other ACTH secretagogues, such as arginine vasopressin (AVP), cholecystokinin, met-enkephalin and dynorphin- into the hypophyseal portal blood via their projecting axons to the median eminence.
CRH and substance P are depleted in the rat spinal cord and dorsal root ganglia in response to capsaicin, which is toxic for the sensory afferent fibers (53).
To perform a CRH test, blood is drawn for baseline ACTH and cortisol levels at -15 and 0 minutes followed by a 1 mg/kg dose of oCRH administered as an IV bolus.
The use of CRH in this setting is based on the principle that pituitary tumors are responsive to exogenous CRH, whereas ectopic and adrenal tumors are not.
The second use of CRH is to enhance the diagnostic accuracy of bilateral inferior petrosal sinus sampling (BIPSS) for ACTH.
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