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Encyclopedia > CX3CL1
chemokine (C-X3-C motif) ligand 1
Identifiers
Symbol CX3CL1 SCYD1, NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin
HUGO 10647
Entrez 6376
OMIM 601880
RefSeq NM_002996
UniProt P78423
PDB 1B2T
Other data
Locus Chr. 16 q13

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a small cytokine, which is the only known member of the the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice).[1][2] The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines. For example, the spacing of the characteristic N-terminal cysteines differs; there are three amino acids separating the initial pair of cysteines in CX3CL1, with none in CC chemokines and only one intervening amino acid in CXC chemokines. CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed.[2] CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1.[3] Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.[2][4] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... Short and long arms Chromosome. ... Chromosome 16 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... The N-terminal end (also known as the N-terminus, N-terminal domain or amine-terminus) refers to the extremity of a protein or polypeptide terminated by an amino acid with a free amine group (-NH2). ... Cysteine is a naturally occurring amino acid which has a thiol group and is found in most proteins, though only in small quantities. ... Phenylalanine is one of the standard amino acids. ... Chemokines are a class of chemotactic cytokines, or small secreted protein signals. ... Chemokines are a class of chemotactic cytokines, or small secreted protein signals. ... Mucins are a family of large, heavily glycosylated proteins. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Monocyte A monocyte is a leukocyte, part of the human bodys immune system that protect against blood-borne pathogens and move quickly to sites of infection in the tissues. ... Chromosome 16 is one of the 23 pairs of chromosomes in humans. ... Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). ... Chemokine (C-C motif) ligand 22 (CCL22) is a small cytokine belonging to the CC chemokine family that is also known under several other names, including macrophage-derived chemokine (MDC) and stimulated T cell chemotactic protein (STCP-1). ...


References

  1. ^ Pan et al. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387: 611-617, 1997.
  2. ^ a b c Bazan et al. A new class of membrane-bound chemokine with a CX3C motif. Nature 385: 640-644, 1997.
  3. ^ Imai et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530, 1997.
  4. ^ Nomiyama et al. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. Cytogenet. Cell Genet. 81: 10-11, 1998.
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Cytokines: chemokines

CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28 Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. ... For the ICAO airport code see Candle Lake Airpark Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). ... Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. ... Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. ... Regulated upon activation, normal T-cell expressed, and presumably secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. ... Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. ... Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). ... Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). ... Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18 , that has been described in rodents. ... Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18 , that has been described in rodents. ... Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. ... Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been decribed in mice. ... Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. ... Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). ... Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). ... Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). ... Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). ... Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 22 (CCL22) is a small cytokine belonging to the CC chemokine family that is also known under several other names, including macrophage-derived chemokine (MDC) and stimulated T cell chemotactic protein (STCP-1). ... Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). ... Chemokine (C-C motif) ligand 24 (CCL24) is a small cytokine belonging to the CC chemokine family that is also known as Myeloid progenitor inhibitory factor 2 (MPIF-2) and Eosinophil chemotactic protein 2 (Eotaxin-2). ... Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK. CCL25 is believed to play a role in the development of T-cells. ... Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary... Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family also known under the names IL-11 R-alpha-locus chemokine (ILC), Skinkine, ESkine and Cutaneous T-cell-attracting chemokine (CTACK). ... CCL28, is a type of cytokine called a chemokine, that is also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, and regulates chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. ...


CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17 Platelet factor 4 is a chemokine ligand involved in moderating the effects of heparin. ... Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. ... SDF-1 (stromal cell-derived factors) 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. ...


CX3CL1


XCL1 - XCL2

 
 

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