NationMaster - Encyclopedia: CXCL1

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). It is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis.^[1]^[2] CXCL1 is expressed by macrophages, neutrophils and epithelial cells,^[3]^[4] and has neutrophil chemoattractant activity.^[5]^[6] CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.^[7]^[8]^[9]^[10] This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.^[7] The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines.^[11] The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... Look up Hugo in Wiktionary, the free dictionary. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... National Center for Biotechnology Information logo The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). ... A mitogen is a chemical, usually some form of a protein that encourages a cell to commence cell division, triggering mitosis. ... Pathogenesis is the mechanism by which a certain etiological factor causes disease (pathos = disease, genesis = development). ... Macrophages (Greek: big eaters) are cells found in tissues that are responsible for phagocytosis of pathogens, dead cells and cellular debris. ... Neutrophil granulocytes (commonly referred to as neutrophils) are a class of white blood cells and are part of the immune system. ... In zootomy, epithelium is a tissue composed of a layer of cells. ... Angiogenesis is the physiological process involving the growth of new blood vessels from pre-existing vessels. ... An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... Wound healing, or wound repair, is the bodys natural process of regenerating dermal and epidermal tissue. ... Tumorigenesis is the formation of tumors in the body, often caused by oncogenes. ... CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. ... For other uses, see Gene (disambiguation). ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ...

Categories: Protein pages needing a picture | Genes on chromosome 4 | Cytokines | Protein stubs Cytokines are a group of proteins and peptides that are used in organisms as signaling compounds. ... Chemokines are a family of pro-inflammatory activation-inducible cytokines, or small protein signals secreted by cells. ... Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. ... For the ICAO airport code see Candle Lake Airpark Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). ... Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. ... Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. ... Regulated upon activation, normal T-cell expressed, and presumably secreted or RANTES is an 8kDa protein classified as a chemotactic cytokine or chemokine. ... Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents. ... Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). ... Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). ... Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called macrophage inflammatory protein-1 gamma (MIP-1Î³), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18 , that has been described in rodents. ... Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family, also called macrophage inflammatory protein-1 gamma (MIP-1Î³), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18 , that has been described in rodents. ... Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. ... Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been decribed in mice. ... Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family that is also known as leukotactin-1, MIP5 and HCC-2. ... Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). ... Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). ... Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). ... Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). ... Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. ... Chemokine (C-C motif) ligand 22 (CCL22) is a small cytokine belonging to the CC chemokine family that is also known under several other names, including macrophage-derived chemokine (MDC) and stimulated T cell chemotactic protein (STCP-1). ... Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). ... Chemokine (C-C motif) ligand 24 (CCL24) is a small cytokine belonging to the CC chemokine family that is also known as Myeloid progenitor inhibitory factor 2 (MPIF-2) and Eosinophil chemotactic protein 2 (Eotaxin-2). ... Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK. CCL25 is believed to play a role in the development of T-cells. ... Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary... Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family also known under the names IL-11 R-alpha-locus chemokine (ILC), Skinkine, ESkine and Cutaneous T-cell-attracting chemokine (CTACK). ... CCL28, is a type of cytokine called a chemokine, that is also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, and regulates chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. ... Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). ... Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). ... Platelet factor 4 is a chemokine ligand involved in moderating the effects of heparin. ... Chemokine (C-X-C motif) ligand 5 (CXCL5) is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). ... Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). ... Chemokine (C-X-C motif) ligand (CXCL7) is a small cytokine belonging to the CXC chemokine family. ... Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. ... Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). ... Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (Î³-IP10 or IP-10). ... Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). ... SDF-1 (stromal cell-derived factors) 1-alpha and 1-beta are small cytokines that belong to the intercrine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. ... Chemokine (C-X-C motif) ligand 13 (CXCL13) is a small cytokine belonging to the CXC chemokine family that is also known as B lymphocyte chemoattractant (BLC). ... Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). ... Chemokine (C-X-C motif) ligand 15 (CXCL15) is a small cytokine belonging to the CXC chemokine family that has been described in the mouse. ... Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. ... Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. ... Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a small cytokine, which is the only known member of the the CX3C chemokine family. ... Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. ... Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1. ...

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