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Encyclopedia > CYP1A2

CYP1A2


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Breast Cancer Research | Full text | Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a ... (7359 words)
CYP1A2 activity was found in both menopausal groups, through stepwise and maximum R regression, to be independently associated with a number of covariates, including smoking status, serum levels of SHBG, circulating levels of blood cholesterol, and triglycerides.
In a twin study of Caucasians conducted in Denmark [28], CYP1A2 activity was determined for 49 monozygotic twin pairs and 34 same-sex dizygotic twin pairs concordant for nonsmoking and nonuse of oral contraceptives.
CYP1A2 activity is lower in women [6], reduced by 35–50% during pregnancy [7], inhibited by oral contraceptives [6] and hormone replacement therapy [43], and may be lower during the late luteal phase of the menstrual cycle, when estradiol concentrations peak [44].
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