Cafe-au-lait spots are pigmented birthmarks. Their name, which is French for "coffee with milk," comes from their light-brown color. A birthmark, also known as a Naevus, is a blemish on the skin formed before birth. ...
McCune-Albright syndrome (MAS) is defined as the association of polyostotic fibrous dysplasia (PFD) (see Image 1), precocious puberty, café aulaitspots, and other endocrinopathies due to hyperactivity of various endocrine glands.
Among the endocrine syndromes described in association with MAS are (1) hyperthyroidism, (2) acromegaly, (3) gonadotrophinomas, (4) hyperprolactinemia, (5) Cushing syndrome, (6) hyperparathyroidism, (7) gynecomastia, and (8) hypophosphatemic rickets.
The disease can be diagnosed at birth (presence of café aulaitspots) and can be definitely diagnosed by early childhood in cases with severe PFD or by adolescence (due to the development of precocious puberty).
Café aulaitspots or cafe-au-lait spots (CAL) are pigmented birthmarks.
The name café aulait is French for "coffee with milk" and refers to their light-brown color.
While café aulaitspots are usually not associated with any medical problems, having many (three or more) such spots is linked with neurofibromatosis and the rare McCune-Albright syndrome
Feeds |
Contact