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Calcineurin A and B (705 words) |
 | Calcineurin is a Ca/calmodulin-dependent serine-threonine phosphatase that plays an important role in transducing Ca-dependent signals in a variety of cell types. |
| It is a heterodimers of two subunits: Calcineurin B/CnB, the 19-kda Ca+-binding and regulatory subunit, and Calcineurin A/CnA, ~61-kda catalytic subunit that is highly homologous with PP1 and PP2A. |
| Calcineurin mediated dephosphorylation of the nuclear factor of activated T-cells (NF-AT) is required for NF-AT activation, nuclear translocation, and subsequent gene expression in T-cells. |
| Cancer Cell International | Full text | Downregulation of calcineurin activity in cervical carcinoma (4262 words) |
| Calcineurin is a heterodimeric protein consisting of a catalytic subunit (calcineurin A), with an active metal binding centre, and a regulatory subunit (calcineurin B), which binds to calcium [19]. |
| Calcineurin is involved in a wide variety of biological responses including neuronal and muscle development, neurite outgrowth, morphogenesis of vertebrate heart valves, memory development, behavioral response etc [21-26]. |
| Calcineurin activity was assayed in both sera and tissue lysate by measuring the dephosphorylation of RII peptide, a specific substrate of calcineurin. |
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