Calcipotriol (INN) (Calcipotriene (USAN)) is a topicalmedication used for the treatment of psoriasis. Calcipotriol has minimal side effects, can be used over the short- or long-term, and achieves results quickly. It is available as a cream, ointment, or solution. An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... In medicine, a topical medication is applied to body surfaces such as the skin or mucous membranes such as the vagina, nasopharynx, or the eye. ... Oral medication A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... A side-effect is any effect other than an intended primary effect. ...
Most of the biological actions of calcipotriol and other vitamin D analogs are mediated by the vitamin D receptor [11, 12].
The vitamin D receptor functions as a ligand-induced transcription factor, regulating the rate of gene expression involved in the control of calcium homeostasis and bone remodelling, control of hormone secretion, inhibition of cell growth, and induction of cell differentiation [13, 14, 15].
Calcipotriol is also an immunomodulator that interacts with cells, especially antigen-presenting cells [12, 16, 17, 18, 19].
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