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Work Report (1922 words) |
 | Calcium is thought to be involved in the pathogenetic mechanisms of amoebiasis. |
| This monomeric protein shows homology with many calcium binding proteins only in the calcium binding loops and not in the inter-loop regions which are suspected to be the sites that interact with other proteins. |
| ANS binding data shows the solvation of myristoyl group in the presence of Ca, which might be due to the presence of a Ca -myristoyl switch. |
| GBP Binding Selectivity (5557 words) |
| This trend was absent in the case of the binding protein where each of the three ions was invariably coordinated by eight oxygen atoms, with the averaged values being 7.9 for Mg++, 7.9 for Ca++, and 8.0 for Ba++. |
| To isolate the source of this electrostatic strain in the protein, a further decomposition of the average Ca++-Mg++ difference in nonbonded interaction energy in the inner and outer coordinating shells (reflecting the eight coordinating oxygen atoms versus the rest of the protein) was performed (figure 7), again using the non-perturbation dynamics trajectories. |
| The Mg++-induced protein strain (relative to Ca++-ligated) is subdivided into three ensemble average Ca++-Mg++ difference components: the nonbonded interaction energy of the inner shell of eight oxygens (left), that of the protein (center), and that between the inner shell and the rest of the protein (right). |
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