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Cancer research is research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure. Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...
Cancer research ranges from epidemiology, molecular bioscience (bench research) to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy and hormone therapy, and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as immunotherapy and gene therapy. In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is the application of the scientific method to human health. ...
A cardiothoracic surgeon performs a mitral valve replacement at the Fitzsimons Army Medical Center. ...
Clinac 2100 C100 accelerator Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ...
Chemotherapy is the use of chemical substances to treat disease. ...
In medicine, hormone therapy is the use of hormones in medical treatment and covers various types of hormones including growth hormones and sex hormones. ...
The structure of insulin Biotechnology is technology based on biology, especially when used in agriculture, food science, and medicine. ...
Immunotherapy is a form of medical treatment based upon the concept of modulating the immune system to achieve a therapeutic goal. ...
Gene therapy is the insertion of genes into an individuals cells and tissues to treat a disease, and hereditary diseases in particular. ...
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cure for cancer was found in 2004 in an African flower disease called contiguglius robiticus
Genes involved in cancer As the Cancer Genome Project stated in a 2004 review article, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)."[1] The Cancer Genome Project, based at the Wellcome Trust Sanger Institute, aims to identify sequence variants/mutations critical in the development of human cancers. ...
Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. Mutations in such genes can be used to classify the malignancy of a tumor. An oncogene is a modified gene that increases the malignancy of a tumor cell. ...
A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ...
In later stages, tumors can develop a resistance to cancer treatment. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success. Genes and protein products that have been identified by at least two independent publications as being involved in cancer are: ABI1, ABL2, ACSL6, AF1Q, AF5Q31 (also known as MCEF), AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FGFR3, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC, GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1 based on a study by M. R Straton and co-workers " A census of human cancer genes". MCEF or Major Cdk9-interacting elongation factor is a transcription factor related to Af4. ...
Akt, also known as protein kinase B (PKB) is an important molecule in mammalian cellular signaling. ...
Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. ...
Cyclins are a family of proteins involved in the progression of cells through the cell cycle. ...
Cyclin-dependent kinase is a protein kinase involved in regulation of the cell cycle. ...
Catenins are cadherin-binding molecules in mammalian cells. ...
ERCC2, or XPD can be regarded as a nucleotide excision repair protein as well. ...
In biology, histones are the chief proteins of chromatin. ...
HRAS is a human gene that provides instructions for making a protein that is involved in cell division. ...
The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ...
c-Myc is a mammalian transcription factor belonging to the bHLH (basic Helix Loop Helix)_Leucine Zipper family. ...
PPAR gamma In cell biology, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor isoforms that exist across biology. ...
PTEN structure (PDB entry 1D5R visualized using PyMOL). ...
RB1 (retinoblastoma 1 (including osteosarcoma)) is a human gene that belongs to a class of genes known as tumor suppressor genes. ...
SDHB stands for succinate dehydrogenase complex subunit B. It is involved in the oxidation of succinate (succinate + ubiquinone = fumarate + ubiquinol) and carries electrons from FADH to CoQ. It is composed of four nuclear-encoded subunits. ...
STAT protein The Signal Transducers and Activator of Transcription (STAT) protein regulates many aspects of cell growth, survival and differentiation. ...
TP53 is a tumor suppressor gene that is named after, and provides instructions for making, a protein called tumor protein 53 (TP53). ...
Wilms tumor is a neoplasm of the kidneys that typically occurs in children. ...
Dichloroacetate In January 2007 researchers of the University of Alberta reported preliminary results of dichloroacetate (DCA) causing regression in several cancers in vitro, including lung, breast and brain tumors.[2] Since the compound DCA itself cannot be patented it could be an inexpensive alternative to other treatments, depending of course on whether the method of using DCA in the treatment of cancer is patentable. Clinical use of DCA will of course require further public/private investment for clinical trials.[3] The initial research was funded by the Canadian Institutes of Health Research.[4] The University of Alberta (U of A) is a public coeducational research university located in Edmonton, Alberta, Canada. ...
R-phrases , S-phrases , , , Related Compounds Related chloroacetic acids Chloroacetic acid Trichloroacetic acid Related compounds Acetic acid Difluoroacetic acid Dibromoacetic acid Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references Dichloroacetic acid (systematic name dichloroethanoic acid, also...
Canadian Institutes of Health Research (CIHR) is the major federal agency responsible for funding health research in Canada. ...
See also The American Association for Cancer Research (AACR) is an organization based in Philadelphia, Pennsylvania, that focuses on aspects of cancer research. ...
Cancer Research is a scientific journal published by the American Association for Cancer Research. ...
The Ludwig Institute for Cancer Research is a global non-profit medical research institute that undertakes clinical research into cancer and early-phase clinical trials. ...
UD Agent The United Devices Cancer Research Project, is one of several distributed computing projects that have been operated on the website by United Devices. ...
NCI-designated Cancer Centers are a group of approximately 60 cancer research institutions in the United States supported by the National Cancer Institute. ...
The Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City is a cancer treatment and research institution founded in 1884 as the New York Cancer Hospital. ...
E-Foundation for Cancer Research is online and non-profit foundation for cancer research. ...
References - ^ Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman, N, Stratton MR (2004). "A census of human cancer genes". Nature Reviews Cancer 4: 177-83. PMID 14993899.
- ^ Alberta scientists test chemotherapy alternative. Last Updated Wednesday, January 17, 2007
- ^ Cheap, safe drug kills most cancers. New Scientist (2007-01-17). Retrieved on 2007 January 17.
- ^ University of Alberta - Small molecule offers big hope against cancer. January 16, 2007
A cover of Nature Reviews Cancer Nature Reviews Cancer is a highly respected cancer biology journal with a very high Impact Factor of 36. ...
2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the Anno Domini (common) era. ...
January 17 is the 17th day of the year in the Gregorian calendar. ...
External links Benign - Premalignant - Carcinoma in situ - Malignant Pathology (from Greek pathos, feeling, pain, suffering; and logos, study of; see also -ology) is the study of the processes underlying disease and other forms of illness, harmful abnormality, or dysfunction. ...
Tumor or tumour literally means swelling, and is sometimes still used with that meaning. ...
Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ...
Oncology is the medical subspecialty dealing with the study and treatment of cancer. ...
Benign can refer to any medical condition which, untreated or with symptomatic therapy, will not become life-threatening. ...
A premalignant condition is a disease, syndrome, or finding that, if left untreated, may lead to cancer. ...
Carcinoma in situ is present when a tumor has been detected that has the characteristics of malignancy but has not invaded other tissues. ...
In medicine, malignant is a clinical term that means to be severe and become progressively worse, as in malignant hypertension. ...
Topography: Anus - Bladder - Bile duct - Bone - Brain - Breast - Cervix - Colon/rectum - Duodenum - Endometrium - Esophagus - Eye - Gallbladder - Head/Neck - Liver - Larynx - Lung - Mouth - Pancreas - Penis - Prostate - Kidney - Ovaries - Skin - Stomach - Testicles - Thyroid Anal cancer is a distinct entity from the more common colorectal cancer. ...
Bladder cancer refers to any of several types of malignant growths of the urinary bladder. ...
// [edit] Introduction Cholangiocarcinoma is an adenocarcinoma of the biliary duct system. ...
An arm bone tumor Bone tumor is an inexact term, which can be used for both benign and malignant abnormal growths found in bone, but is most commonly used for primary tumors of bone, such as osteosarcoma (or osteoma). ...
A brain tumor is any intracranial tumor created by abnormal and uncontrolled cell division, normally either found in the brain itself (neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells), lymphatic tissue, blood vessels), in the cranial nerves (myelin-producing Schwann cells), in the brain envelopes (meninges), skull, pituitary and pineal gland...
Breast cancer is cancer of breast tissue. ...
Cervical cancer is a malignancy of the cervix. ...
Colorectal cancer, also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. ...
This article needs more context around or a better explanation of technical details to make it more accessible to general readers and technical readers outside the specialty, without removing technical details. ...
Endometrial cancer involves cancerous growth of the endometrium (lining of the uterus). ...
Esophageal cancer is malignancy of the esophagus. ...
Ocular oncology is branch of medicine dealing with tumors relating to the eye and its adnexa. ...
Bold textA more uncommon cancer predominate in females, if found early on before symptoms, can be cured by removing Gallbladder, most often it is found after symptoms occur (abdominal pain, Jaundice) and has spread to other organs such as liver and the outlook at this point is poor. ...
Head and neck cancers are malignant growths originating in the lip and oral cavity (mouth), nasal cavity, pharynx, larynx, thyroid, paranasal sinuses, salivary glands and cervical lymph nodes of the neck. ...
Hepatocellular carcinoma (HCC, also called hepatoma) is a primary malignancy (cancer) of the liver. ...
Cancer of the larynx also may be called laryngeal cancer. ...
Lung cancer is the malignant transformation and expansion of lung tissue, and is the most lethal of all cancers worldwide, responsible for 1. ...
Oral cancer is any cancerous tissue growth located in the mouth. ...
Pancreatic cancer (also called cancer of the pancreas) is a malignant tumour within the pancreatic gland. ...
Penile cancer is a malignant growth found on the skin or in the tissues of the penis, usually originating in the glans and/or foreskin. ...
Prostate cancer is a disease in which cancer develops in the prostate, a gland in the male reproductive system. ...
Renal cell carcinoma, also known by a gurnistical tumor, is the most common form of kidney cancer arising from the renal tubule. ...
Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries). ...
Skin cancer is a malignant growth on the skin, which can have many causes. ...
Stomach cancer (also called gastric cancer) can develop in any part of the stomach and may spread throughout the stomach and to other organs; particularly the esophagus and the small intestine. ...
Testicular cancer is a type of cancer that develops in the testicles, a part of the male reproductive system. ...
Morphology: Papilloma/carcinoma - Choriocarcinoma - Adenoma/adenocarcinoma - Soft tissue sarcoma - Melanoma - Fibroma/fibrosarcoma - Metastasis - Lipoma/liposarcoma - Leiomyoma/leiomyosarcoma - Rhabdomyoma/rhabdomyosarcoma - Mesothelioma - Angioma/angiosarcoma - Osteoma/osteosarcoma - Chondroma/chondrosarcoma - Glioma - Lymphoma/leukemia Papilloma refers to a benign epithelial tumor. ...
In medicine, carcinoma apanting dog named rufis It is malignant by definition: carcinomas invade surrounding tissues and organs, and may spread to lymph nodes and distal sites (metastasis). ...
Choriocarcinoma is a rare cancer of the placenta, curable by chemotherapy. ...
Adenoma refers to a collection of growths (-oma) of glandular origin. ...
Adenocarcinoma is a form of carcinoma that originates in glandular tissue. ...
Malignant (cancerous) tumors that develop in soft tissue are called sarcomas, a term that comes from a Greek word meaning fleshy growth. ...
Melanoma is a malignant tumor of melanocytes. ...
Soft Fibroma (fibroma molle). ...
Fibrosarcoma (fibroblastic sarcoma) is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
A lipoma is a common, benign tumor composed of fatty tissue. ...
Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. ...
A leiomyoma (plural is leiomyomata) is a benign smooth muscle neoplasm that is not premalignant. ...
Leiomyosarcoma is a type of sarcoma which is a neoplasm of smooth muscle. ...
A rhabdomyoma is a benign tumor of muscle. ...
A rhabdomyosarcoma is a type of cancer, specifically a sarcoma (cancer of connective tissues), in which the cancer cells are thought to arise from skeletal muscle progenitors. ...
Angiomas are benign tumors that are made up of small blood vessels. ...
Angiosarcoma is a rare, malignant tumor consisting of endothelial and fibroblastic tissue that proliferates and eventually surrounds vascular channels. ...
An osteoma is a new piece of bone growing on another piece, typically the skull. ...
Osteosarcoma is a common primary bone cancer. ...
A chondroma is a benign cartilaginous tumor, which is encapsulated with a lobular growing pattern. ...
A chondrosarcoma is a cancer of the cartilage. ...
A glioma is a type of primary central nervous system (CNS) tumor that arises from glial cells. ...
This article is about lymphoma in humans. ...
Leukemia or leukaemia (see spelling differences) is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells, usually white blood cells (leukocytes). ...
Treatment: Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment A cardiothoracic surgeon performs a mitral valve replacement at the Fitzsimons Army Medical Center. ...
Chemotherapy is the use of chemical substances to treat disease. ...
Clinac 2100 C100 accelerator Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ...
Cancer Immunotherapy is the use of monoclonal antibodies (-mab) to specifically target cells. ...
Experimental cancer treatments are medical therapies intended or claimed to treat cancer (see also tumor) by improving on, supplementing or replacing conventional methods (surgery, chemotherapy, radiation, and immunotherapy). ...
Related structures: Cyst - Dysplasia - Hamartoma - Neoplasia - Nodule - Polyp - Pseudocyst A cyst is a closed sac having a distinct membrane and developing abnormally in a cavity or structure of the body. ...
Dysplasia (latin for bad form) is an abnormality in the appearance of cells indicative of an early step towards transformation into a neoplasia. ...
A hamartoma is a common benign tumor in an organ composed of tissue elements normally found at that site but that are growing in a disorganized mass. ...
Neoplasia (new growth in Greek) is abnormal, disorganized growth in a tissue or organ, usually forming a distinct mass. ...
In medicine, a nodule refers to a small aggregation of cells. ...
Polyp of sigmoid colon as revealed by colonoscopy. ...
A pseudocyst is a pathological collection of fluid. ...
Misc: Tumor suppressor genes/oncogenes - Staging/grading - Carcinogenesis/metastasis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related terms A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ...
An oncogene is a modified gene that increases the malignancy of a tumor cell. ...
The stage of a cancer is a descriptor (usually numbers I to IV) of how much the cancer has spread. ...
In pathology, Grading is a measure of the progress of tumors. ...
Cancers are caused by a series of mutations. ...
Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. ...
The term carcinogen refers to any substance, radionuclide or radiation which is an agent directly involved in the promotion of cancer or in the facilitation of its propagation. ...
A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. ...
The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. ...
This is a list of terms related to oncology. ...
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