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Encyclopedia > Cannabis (pharmacology)

For more information on the pharmacology of cannabis please see Cannabis (drug), Health issues and the effects of cannabis, and Medical Marijuana. For various other aspects please see the main article at Cannabis. A Cannabis sativa plant The cannabis plant can be dried or otherwise processed to yield products containing large concentrations of compounds that have medicinal and psychoactive effects when consumed, usually by smoking or eating. ... For other articles on health aspects of cannabis please see Medical Marijuana and Cannabis (drug). ... Cannabis sativa extract. ... Species Cannabis indica Cannabis ruderalis Cannabis sativa Cannabis is a genus of flowering plant that includes one or more species. ...

The pharmacology of cannabis is complex, due to a wide variety of terpenoid and terpenophenolic compounds (cannabinoids) in the essential oil. The most important pharmacologically active cannabinoids are delta-9-tetrahydrocannabinol (Δ9-THC), cannabidiol, and cannabinol (a degradation product of Δ9-THC). Image File history File links Thc_3d. ... Image File history File links Thc_3d. ... Chemical structure is the arrangement of atoms within a molecule, usually linked by covalent bonds. ... The acronym THC has several possible meanings: Tetrahydrocannabinol, the active ingredient in Cannabis Therapeutic Humane Cannabis Act Texas Historical Commission Thermohaline circulation The History Channel Terminal Handling Charges This page concerning a three-letter acronym or abbreviation is a disambiguation page — a navigational aid which lists other pages that might... Pharmacology (in Greek: pharmacon (φάρμακον) meaning drug, and logos (λόγος) meaning science) is the study of how chemical substances interact with living systems. ... A Cannabis sativa plant The cannabis plant can be dried or otherwise processed to yield products containing large concentrations of compounds that have medicinal and psychoactive effects when consumed, usually by smoking or eating. ... Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. ... Cannabidiol, also known as CBD, is a non-psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabinol, also known as CBN, is a non_psychoactive cannabinoid found in the hemp plant Cannabis sativa. ...

Contents


Delta-9-Tetrahydrocannabinol (THC)

Micro shot of mature glandular trichomes, from Overgrow.
Enlarge
Micro shot of mature glandular trichomes, from Overgrow.

The best known component of cannabis is THC. This psychoactive compound may produce relaxation, euphoria, concentration or diffusion of attention, altered space-time perception, alteration of visual, auditory, and olfactory senses, and appetite stimulation. Image File history File links Trichome-close-up. ... Image File history File links Trichome-close-up. ... Trichomes, from the Greek meaning growth of hair, are fine outgrowths or appendages on plants and protists. ... Overgrow photo of the week Overgrow is an online magazine for cannabis growers, containing information about cannabis cultivation written by the users, staff, and owners of overgrow. ...


Cannabis strains cultivated for medicinal, spiritual, and recreational use have a high content of THC, whereas certified industrial hemp strains have a low THC content. A female cannabis flower just coming into bloom (Photo courtesy sponng) Cannabis cultivation is the cultivation of the cannabis plant. ... Cannabis sativa extract. ... Cannabis has a long history of spiritual use, especially in India, where it has been used by wandering spiritual sadhus for centuries. ... The number 420 is a euphemism for cannabis and its associated culture. ...


Most hemp farmers try to maximize the amount of fiber, seed, or oil that the plants produce. However, most marijuana growers try to maximize the number of glandular trichomes produced on the floral clusters of unfertilized female plants. The glandular trichomes secrete an essential oil having high concentrations of cannabinoids.


Cannabinoids

Macro shot of fairly mature glandular trichome, from Overgrow.
Enlarge
Macro shot of fairly mature glandular trichome, from Overgrow.

In addition to Δ9-THC, the essential oil of cannabis includes the non- psychoactive cannabinoids cannabinol, cannabidiol and cannabinolic acid. These latter compounds are thought to produce certain beneficial effects such as cell protection, immunomodulation, and anti-inflammatory properties. Image File history File links Trichome-cystolithhairs. ... Image File history File links Trichome-cystolithhairs. ... A psychoactive drug or psychotropic substance is a chemical that alters brain function, resulting in temporary changes in perception, mood, consciousness, or behaviour. ... Cannabinol, also known as CBN, is a non_psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabidiol, also known as CBD, is a non-psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... An immunomodulator is a drug used for its effect on the immune system: drugs may be immunosuppressants or immunostimulators. ... Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. ...


Cannabinoids usually contain a 1,1'-di-methyl-pyrane ring, a variedly derivatized aromatic ring and a variedly unsaturated cyclohexyl ring and their immediate chemical precursors, constituting a family of about 60 bi-cyclic and tri-cyclic compounds. An aromatic hydrocarbon (abbreviated as AH), or arene is a hydrocarbon, the molecular structure of which incorporates one or more planar sets of six carbon atoms that are connected by delocalised electrons numbering the same as if they consisted of alternating single and double covalent bonds. ...


Cannflavins

Cannabis also contains a related class of compounds, the cannflavins. These compounds have been suggested to contribute certain beneficial effects of cannabis, such as analgesia and anti-inflammatory properties, and are considerably more effective than aspirin. For other uses of painkiller, see painkiller (disambiguation) An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain. ... Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ...


Cannaflavins usually contain a 1,4-pyrone ring fused to a variedly derivatized aromatic ring and linked to a 2nd variedly derivatized aromatic ring and include for example the non-psychoactive cannflavins A and B.


Terpenoids

The essential oil of cannabis also contains many fragrant terpenoids, which may synergize with the cannabinoids to produce its unique effects. The terpenoids, sometimes referred to as isoprenoids, are a class of naturally occurring chemicals similar to terpenes, derived from five-carbon isoprene units assembled and modified in thousands of ways. ...


The cannabinoid receptor system

Humans and other animals have two types of cannabinoid receptors: CB1 and CB2. The activation of these receptors is responsible for several of the medicinal and psychotropic effects of consuming cannabis. The discovery of these receptors in the 1980s revolutionized the understanding of cannabis pharmacology, reinforcing many long-standing assertions about its medical efficacy, and suggesting possibilities for cannabis-derived pharmaceutical compounds developed for specific medical purposes. Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... The 1980s decade refers to the years from 1980 to 1989, inclusive. ...


See also


Cannabinoids edit

{Anandamide} {CBD} {CBDV} {CBN} {CBV} {CP 55,940} {HU-210} {Nabilone} {Rimonabant} {THC} {THCV} {WIN 55,212-2} Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... Anandamide, also known as arachidonoylethanolamine or AEA, is a naturally occurring endogenous cannabinoid neurotransmitter found in the brain of animals, as well as other organs. ... Cannabidiol, also known as CBD, is a non-psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabidivarine, also known as cannabidivarol or CBDV, is a non_psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Cannabinol, also known as CBN, is a non_psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabivarin, also known as cannabivarol or CBV, is a non_psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Chemical structure of CP 55,940 CP 55,940, also written as CP55940, CP55,940, CP-55940, CP-55,940, and CP 55940, is a cannabinoid which mimics the effects of naturally occurring THC (the psychoactive compound found in marijuana). ... HU-210 is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. ... Chemical structure of (R,R)-nabilone. ... This article or section has or is prone to spam, that is, HTML links added only to promote a site or product. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. ... Tetrahydrocannabivarin, also known as tetrahydrocannabivarol, THCV, or THV, is a psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ...

Cannabis resources (edit)
Use: recreational drug, pharmaceutical drug, spiritual, culture, health issues, pharmacology, legal issues, cultivation
Preparations: hashish, kief, bhang, shake
Smoking: smoking pipe, spliff, bong, shotgun, dugout, steamroller, blunt, gravity bong
Vaporization: vaporizer, knifers
Food: hash cookie, cannabutter, Leary biscuit, magic brownies, dope cake, pot tea, green dragon, Ganja goo ball


 

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