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Penile cancer is a malignant growth found on the skin or in the tissues of the penis, usually originating in the glans and/or foreskin. It is a rare form of cancer with an annual incidence of 1 in 100,000 in developed countries.[1] Image File history File links Broom_icon. ... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ... // C00-D48 - Neoplasms (C00-C14) Malignant neoplasms, lip, oral cavity and pharynx (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and unspecified parts of tongue (C03) Malignant neoplasm of gum (C04) Malignant neoplasm of floor of mouth (C05) Malignant neoplasm of... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ... The penis (plural penises, penes) is an external male sexual organ. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ... A developed country is a country that is technologically advanced and that enjoys a relatively high standard of living. ...

Risk factors

The American Cancer Society provides the following as risk factors for penile cancer: human papillomavirus (HPV) infection, smoking, smegma, phimosis, lack of circumcision, treatment of psoriasis, age, and AIDS. The other etiologic factor most commonly associated with penile carcinoma is poor hygiene. HPV redirects here. ... Look up Smoking in Wiktionary, the free dictionary. ... Smegma, a transliteration of the Greek word σμήγμα for soap, is a combination of exfoliated (shed) epithelial cells, transudated skin oils, moisture, and bacteria that can accumulate under the foreskin of males and within the vulva of females. ... Phimosis is a medical condition in which the foreskin of the penis of an uncircumcised male cannot be fully retracted. ... This article is about male circumcision. ... This article is about the syndrome. ...

There is some evidence that lichen sclerosus (also known as balanitis xerotica obliterans) may also be a risk factor.[2] Discussion Balanitis xerotica obliterans (BXO) is a skin disease of unknown origin. ...

Risk

While treatment is often easy, the overall 5-year survival rate for all stages of penile cancer is about 50%. Specifically in the United States the lifetime risk of an uncircumcised man for developing invasive penile cancer (IPC) is one in 600 [3], which is in excess of 3 times higher than for males neonatally circumcised.[4][5][6]

The evidence indicates that childhood circumcision reduces the incidence of penile cancer. [7][8][9][10][11][12] This article is about male circumcision. ...

The American Cancer Society noted in a 1998 statement: The American Cancer Society (ACS) is a medical organization with a corporate attitude in the United States. ...

"... penile cancer risk is low in some uncircumcised populations, and circumcision is strongly associated with other socioethnic practices that are associated with lessened risk. The consensus among studies that have taken these other factors into account is that circumcision alone is not the major factor preventing cancer of the penis. It is important that the issue of circumcision not distract the public's attention from avoiding known penile cancer risk factors -- having unprotected sexual relations with multiple partners (increasing the likelihood of human papillomavirus infection) and cigarette smoking."[13]

Studies have found that circumcision decreases the risk of HPV infection in males and thereby the risk of developing penile cancer.[14][15][16]

Wallerstein found that the risk of penile cancer in Finland, Norway, and Denmark (all noncircumcising countries) is about the same (1 in 100,000 per year) as in the U.S.

The American Medical Association and the Royal Australasian College of Physicians say the use of infant circumcision in hope of preventing penile cancer in adulthood is not justified. [17] [18]

Signs and symptoms

A draining sore on the foreskin or glans of the penis may be a sign of penile cancer and anyone with these symptoms should consult a doctor immediately.

Pathology

• A. Precancerous Dermatologic Lesions
• B. Carcinoma in Situ (Bowen Disease, Erythroplasia of Queyrat)
• C. Invasive Carcinoma of the Penis

Staging

Like many malignancies, penile cancer can spread to other parts of the body. It is usually a primary malignancy, the initial place from which a cancer spreads in the body. Much less often is it a secondary malignancy, where cancer has spread to the organ from other anatomy. Doctors use the extent of metastasis to complete a process called staging. Patients will be assigned a "stage" to aid in treatment decisions and prognosis.

Stage I

• Cancer has only affected the glans and/or foreskin.

Stage II
The penis (plural penises, penes) is an external male sexual organ. ...

• Cancer has spread to the shaft of the penis.

Stage III
The penis (plural penises, penes) is an external male sexual organ. ...

• Cancer has affected the penis and surrounding lymph nodes.

Stage IV
Lymph nodes are components of the lymphatic system. ...

• Cancer has moved beyond the groin area to other parts of the body.

Recurrent

• Cancer that has returned after treatment.

Prognosis can range considerably for patients, depending where on the scale they have been staged. Generally speaking, the earlier the cancer is diagnosed, the better the prognosis. The overall 5-year survival rate for all stages of penile cancer is about 50%.

Treatment

There are several treatment options for penile cancer, depending on staging. They include surgery, radiation therapy, chemotherapy, and biological therapy. The most common treatment is one of four types of surgery: A cardiothoracic surgeon performs a mitral valve replacement at the Fitzsimons Army Medical Center. ... Clinac 2100 C100 accelerator Radiation therapy (or Radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ... Chemotherapy is the use of chemical substances to treat disease. ... Immunotherapy is a disease treatment based upon the concept of triggering the bodys own natural defenses to fight off the disease, usually by stimulating the immune system either locally or systemically. ...

Wide Local Excision
This article or section does not cite its references or sources. ...

• The tumor and some surrounding healthy tissue are removed.

Microsurgery

• Surgery performed with a microscope is used to remove the tumor and as little healthy tissue as possible.

Laser Surgery

• Laser light is used to burn or excise cancerous cells.

Circumcision

• Cancerous foreskin is removed from the penis.

Amputation

• The most common and effective treatment of penile cancer is penectomy. A penectomy can range from partial to total removal of the penis. The surgeon may also decide to remove associated lymph nodes.

Radiation therapy is usually used adjuvantly with surgery to reduce the risk of recurrence. With earlier stages of penile cancer, a combination of topical chemotherapy and less invasive surgery may be used. More advanced stages of penile cancer usually require a combination of surgery, radiation and chemotherapy. Penectomy is the surgical removal of the penis for medical reasons. ... Lymph nodes are components of the lymphatic system. ... Clinac 2100 C100 accelerator Radiation therapy (or Radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ... Chemotherapy is the use of chemical substances to treat disease. ...

Vaccine

A quadri-valent vaccine to prevent HPV infection, Gardasil, has been developed, successfully tested and approved by the Food and Drug Administration.[19] This vaccine, which is licenced and in production, could substantially reduce the incidence of HPV infection, the incidence of genital warts and ano-genital cancers, including penile cancer, and reduce mortality.[20] Gardasil is a vaccine against certain types of the human papillomavirus (HPV), created by researchers Dr. Albert Bennet Jenson and Dr. Shin-je Ghim at the University of Louisville in 2006, following on research done by Professor Ian Frazer of Australia in conjunction with Australian biomedical company, CSL Limited. ... The Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services and is responsible for regulating food (humans and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal) and radiation emitting devices (including non-medical devices), biologics, and...

External links

• E.J. Schoen, M. Oehrli, C.J. Colby and G. Machin. The Highly Protective Effect of Newborn Circumcision Against Invasive Penile Cancer. Pediatrics 2000;105(3):e36 Full Text
• C. Maden, K.J. Sherman, A.M. Beckmann, T.G. Hislop, C.Z. Teh, R.L. Ashley and Daling JR. History of Circumcision, Medical Conditions, and Sexual Activity and Risk of Penile Cancer. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Wash. [21]
• Tumors of the Penis Jackson SM: The treatment of carcinoma of the penis. Br J Surg 1966;53:33.
• M Kochen, S McCurdy. Circumcision and the Risk of Cancer of the Penis. A Life-Table Analysis. From the Program in Epidemiology, School of Public Health, University of California, Berkeley. [22]
• Boczko S, Freed S. Penile carcinoma in circumcised males. N Y State J Med 1979;79(12):1903-4. Full text
• Cold CR, Storms MR, Van Howe RS. Carcinoma in situ of the penis in a 76-year-old circumcised man. J Fam Pract 1997;44:407-10. Full text
• Lehtinen M, Paavonen J. Vaccination against human papillomaviruses shows great promise. Lancet 2004;364:1731-2. Full text

References

• Edward Wallerstein. Circumcision: An American Health Fallacy. New York: Springer, 1980: pp. 22, 44, 45, 67, 90, 104-14, 148. (ISBN 0-8261-3240-5)

• Paul M. Fleiss, M.D., and Frederick Hodges, D. Phil. What Your Doctor May Not Tell You About Circumcision. New York, Warner Books, 2002: pp. 150-4. (ISBN 0-446-67880-5)

• Cabanas RM: An approach for the treatment of penile carcinoma. Cancer 1977;39:456.