 Cardiolipin (alternate image) Cardiolipin (bisphosphatidyl glycerol) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid. Image File history File links Download high-resolution version (982x251, 13 KB) cardiolipin. ...
Image File history File links Download high-resolution version (982x251, 13 KB) cardiolipin. ...
Image File history File links Structural formula of Diphosphatidyl glycerol (Blue/Green: Fatty acid, Black: Glycerol backbone, Red: phosphate, Purple: Glycerol) File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ...
Image File history File links Structural formula of Diphosphatidyl glycerol (Blue/Green: Fatty acid, Black: Glycerol backbone, Red: phosphate, Purple: Glycerol) File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ...
Phosphatidate (red: phosphate group, blue & green: fatty acid) Phosphatidates are biochemical compounds that consist of a glycerol backbone, with a (usually) saturated fatty acid bonded to carbon-1, a (usually) unsaturated fatty acid bonded to carbon-2 and a phosphate group bonded to carbon-3. ...
Glycerol, also well known as glycerin and glycerine, and less commonly as propane-1,2,3-triol, 1,2,3-propanetriol, 1,2,3-trihydroxypropane, glyceritol, and glycyl alcohol is a colorless, odorless, hygroscopic, and sweet-tasting viscous liquid. ...
In cell biology, a mitochondrion is an organelle found in the cells of most eukaryotes. ...
Function and structure It is typically present in metabolically active cells of the heart and skeletal muscle. It has also been observed in certain bacterial membranes.
It serves as an insulator and stabilizes the activity of protein complexes important to the electron transport chain. It has been suggested that Complex (biochemistry) be merged into this article or section. ...
The Electron Transport Chain. ...
Cardiolipin is a "double" phospholipid because it has four fatty acid tails, instead of the usual two.
Clinical significance
Barth syndrome Barth syndrome is a rare genetic disorder that was recognised in the 1970's to cause infantile death. It has a mutation in the gene coding for tafazzin, an enzyme involved in the biosynthesis of cardiolipin. Girls heterozygous for the trait are unaffected. Sufferers of this condition have mitochondria that are abnormal, and they cannot sustain adequate production of ATP. Cardiomyopathy and general weakness is common to these patients. Cardiolipin treats the symptoms of BTHS and prevents infections. Barth syndrome is a rare genetic disorder classified by many signs and symptoms, including metabolism distortion, delayed motor skills, stamina deficiency, hypotonia, chronic fatigue, delayed growth, cardiomyopathy, and compromised immune system. ...
Tafazzin is a protein highly expressed in cardiac and skeletal muscle. ...
Biosynthesis is a phenomenon where chemical compounds are produced from simpler reagents. ...
Antiphospholipid syndrome Patients with anticardiolipin antibodies (Antiphospholipid syndrome) can have recurrent thrombotic events even early in their mid-late teen years. These events can occur in vessels where thrombosis may be relatively uncommon, such as the hepatic or renal veins. These antibodies are usually picked up in young women with recurrent spontaneous abortions. This article, image, template or category should belong in one or more categories. ...
Syphilis Cardiolipin from the cow's heart is used as an antigen for the screening test for syphilis. In screening test of syphilis antibody against cardiolipin antigen are used. Antibody against cardiolipn can increase in many other condition like malaria. so this is not specific test. Syphilis is a sexually transmitted disease (STD) caused by a spirochaete bacterium, Treponema pallidum. ...
External links Glycerophospholipids/Phosphoglycerides: Phosphatidylethanolamine - Phosphatidylcholine - Dipalmitoylphosphatidylcholine - Cardiolipin - Phosphatidylserine - ethers (Plasmalogen, Platelet-activating factor)
Phosphatidylinositol - Glycophosphatidylinositol - Phosphatidylinositol 3-phosphate - Phosphatidylinositol (3,4)-bisphosphate - Phosphatidylinositol (3,5)-bisphosphate - Phosphatidylinositol (4,5)-bisphosphate - Phosphatidylinositol (3,4,5)-trisphosphate Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...
Lipids are a class of hydrocarbon-containing organic compounds. ...
Two schematic representations of a phospholipid. ...
Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. ...
Phosphatidylethanolamine is a lipid found in biological membranes. ...
Lecithin, also known as Phosphatidylcholine Lecithin is usually used as synonym for phosphatidylcholine, a phospholipid which is the major component of a phosphatide fraction which may be isolated from either egg yolk (in Greek lekithos - λεκιθος), or soy beans. ...
Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid and the major constituent of pulmonary surfactant. ...
Phosphatidylserine is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes. ...
A plasmalogen is an ether lipid, with an ether-linked alkene (double bond next to the link), also known as vinyl-ether, at the sn-1 position of the glycerol. ...
A platelet-activating factor, also known as a PAF or paf-acether is a potent phospholipid activator and mediator of many leucocyte functions, including platelet aggregation, inflammation, and anaphylaxis. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol Phosphatidylinositol (abbreviated PtdIns, or PI) is a minor phospholipid component of eukaryotic cell membranes. ...
A GPI anchor or glycosylphosphatidylinositol is a common posttranslational modification of the C-terminus of membrane-attached proteins. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate Phosphatidylinositol 3-phosphate (PtdIns3P) is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on Phosphatidylinositol. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,4)-bisphosphate Phosphatidylinositol (3,4)-bisphosphate (PtdIns(3,4)P2) is a minor phospholipid component of cell membranes, it is however an important second messenger. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5)-bisphosphate Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P2) is a minor phospholipid component of cell membranes, it however is important in distinguishing cell compartments. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) is a minor phospholipid component of cell membranes. ...
Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3,4,5-trisphosphate Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) commonly abbreviated to PIP3 is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) activity on Phosphatidylinositol (4,5)-bisphosphate. ...
Sphingomyelin Sphingomyelin is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. ...
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