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Encyclopedia > Cardiovascular disease

Updated 193 days 12 hours 3 minutes ago.
Cardiovascular disease
Classification & external resources
ICD-10 I51.6
ICD-9 429.2
DiseasesDB 28808
MeSH D002318

Cardiovascular disease refers to the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system, it is usually used to refer to those related to atherosclerosis (arterial disease). These conditions have similar causes, mechanisms, and treatments. In practice, cardiovascular disease is treated by cardiologists, thoracic surgeons, vascular surgeons, neurologists, and interventional radiologists, depending on the organ system that is being treated. There is considerable overlap in the specialties, and it is common for certain procedures to be performed by different types of specialists in the same hospital. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). ... // I00-I99 - Diseases of the circulatory system (I00-I02) Acute rheumatic fever (I00) Rheumatic fever without mention of heart involvement (I01) Rheumatic fever with heart involvement (I02) Rheumatic chorea (I05-I09) Chronic rheumatic heart diseases (I05) Rheumatic mitral valve diseases (I050) Mitral stenosis (I051) Rheumatic mitral insufficiency (I06) Rheumatic aortic... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... The heart and lungs, from an older edition of Grays Anatomy. ... f you all The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Section of an artery For other uses, see Artery (disambiguation). ... In the circulatory system, a vein is a blood vessel that carries blood toward the heart. ... For transport in plants, see Vascular tissue. ... Cardiology is the branch of medicine pertaining to the heart. ... In medicine, the field of (cardio)thoracic surgery is involved in the surgical treatment of diseases affecting the heart (cardiovascular disease) and lungs (lung disease). ... Vascular surgery is the branch of surgery that occupies itself with surgical interventions of arteries and veins, as well as conservative therapies for disease of the peripheral vascular system. ... Neurology is a branch of medicine dealing with disorders of the nervous system. ... Interventional Radiology (abbreviated IR or sometimes IVR) is a subspecialty of radiology in which minimally invasive procedures are performed using image guidance. ...


Most Western countries face high and increasing rates of cardiovascular disease. Each year, heart disease kills more Americans than cancer.[1] Diseases of the heart alone caused 30% of all deaths, with other diseases of the cardiovascular system causing substantial further death and disability. Up until the year 2005, it was the number 1 cause of death and disability in the United States and most European countries. A large histological study (PDAY) showed vascular injury accumulates from adolescence, making primary prevention efforts necessary from childhood. [2][3]



By the time that heart problems are detected, the underlying cause (atherosclerosis) is usually quite advanced, having progressed for decades. There is therefore increased emphasis on preventing atherosclerosis by modifying risk factors, such as healthy eating, exercise and avoidance of smoking. Maintaining a healthy diet is the practice of making choices about what to eat with the intent of improving or maintaining good health. ... U.S. Marine emerging from the swim portion of a triathlon. ... The cigarette is the most common method of smoking tobacco. ...

Contents

[edit] Risk factors

There are many risk factors which associate with (but are not all causes of) various forms of cardiovascular disease. These include the following:

  • Non-modifiable Risk Factors
    • Age
    • Gender, men under age 64 are much more likely to die of coronary heart disease than women, although the gender difference declines with age.[4] (The gender difference is less pronounced in blacks than in whites, but it is still significant [5])
    • Genetic factors/Family history of cardiovascular disease

Although men have a higher rate of cardiovascular disease than women, it is also the number one health problem for women in industrialized countries. After menopause, the risk for women approaches that of men. Hormone replacement therapy alleviates a number of post-menopausal problems, but appears to increase the risk of cardiovascular disease. Gender in common usage refers to the sexual distinction between male and female. ... This article is about the general scientific term. ... In medicine, a family history consists of information about disorders that a patients direct blood relatives have suffered from. ... The cigarette is the most common method of smoking tobacco. ... Insulin resistance is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. ... For the disease characterized by excretion of large amounts of very dilute urine, see diabetes insipidus. ... Hypercholesterolemia (literally: high blood cholesterol) is the presence of high levels of cholesterol in the blood [1]. It is not a disease but a metabolic derangement that can be secondary to many diseases and can contribute to many forms of disease, most notably cardiovascular disease. ... Cholesterol is a sterol (a combination steroid and alcohol). ... A lipoprotein is a biochemical assembly that contains both proteins and lipids. ... Central obesity (or apple-shaped or masculine obesity) occurs when the main deposits of body fat are localised around the abdomen and the upper body. ... An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... For other forms of hypertension, see Hypertension (disambiguation). ... Sleep deprivation is a general lack of the necessary amount of sleep. ... Heart rate is a term used to describe the frequency of the cardiac cycle. ... The term sedentary in biology and anthropology applies to organisms and species that are not migratory but rather remain at a single location (permanently fixed or otherwise). ... Omega-3 fatty acids are a family of polyunsaturated fatty acids which have in common a carbon-carbon double bond in the ω-3 position. ... Molecular structure of flavone, a common Polyphenol antioxidant Polyphenol antioxidant is a class of multi-phenolic compounds known for their role of down-regulating free radical formation in mammals . ... Roadway noise is the main source of exposure Noise health effects, the collection of health consequences of elevated sound levels, constitute one of the most widespread public health threats in industrialized countries. ... In medical terms, stress is the disruption of homeostasis through physical or psychological stimuli. ... In everyday language depression refers to any downturn in mood, which may be relatively transitory and perhaps due to something trivial. ... Periodontitis a disease involving inflammation of the gums (gingiva), often persisting unnoticed for years or decades in a patient, that results in loss of bone around teeth. ... Menopause is the physiological cessation of menstrual cycles associated with advancing age in women. ... Hormone replacement therapy (HRT) is a system of medical treatment for perimenopausal and postmenopausal women, based on the assumption that it may prevent discomfort and health problems caused by diminished circulating estrogen hormones. ...


[edit] Biomarkers

Some biomarkers are thought to offer a more detailed risk of cardiovascular disease. However, the clinical value of these biomarkers is questionable.[8] Currently, biomarkers which may reflect a higher risk of cardiovascular disease include: In medicine, a biomarker is an indicator of a particular disease state or a particular state of an organism. ...

Fibrin is a protein involved in the clotting of blood. ... Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). ... Homocysteine is a chemical compound with the formula HSCH2CH2CH(NH2)CO2H. It is a homologue of the naturally-occurring amino acid cysteine, differing in that its side-chain contains an additional methylene (-CH2-) group before the thiol (-SH) group. ... Molecular structure of ADMA Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. ... C-reactive protein (CRP) is a plasma protein, an acute phase protein produced by the liver. ...

[edit] Prevention

Attempts to prevent cardiovascular disease are more effective when they remove and prevent causes, and they often take the form of modifying risk factors. Some factors, such as gender, age, and family history, cannot be modified. Smoking cessation (or abstinence) is one of the most effective and easily modifiable changes. Regular cardiovascular exercise (aerobic exercise) complements the healthful eating habits. According to the American Heart Association, build up of plaque on the arteries (atherosclerosis), partly as a result of high cholesterol and fat diet, is a leading cause for cardiovascular diseases. The combination of healthy diet and exercise is a means to improve serum cholesterol levels and reduce risks of cardiovascular diseases; if not, a physician may prescribe "cholesterol-lowering" drugs, such as the statins. These medications have additional protective benefits aside from their lipoprotein profile improvement. Aspirin may also be prescribed, as it has been shown to decrease the clot formation that may lead to myocardial infarctions and strokes; it is routinely prescribed for patients with one or more cardiovascular risk factors. A No Smoking sign Smoking cessation (commonly known as quitting, or kicking the habit) is the effort to stop smoking tobacco products. ... Aerobic exercise is a type of exercise in which muscles draw on oxygen in the blood as well as fats and glucose, that increase cardiovascular endurance. ... Aerobic exercise refers to exercise that is of moderate intensity, undertaken for a long duration. ... Cholesterol is a sterol (a combination steroid and alcohol). ... Lovastatin, the first statin to be marketed The statins (or HMG-CoA reductase inhibitors) form a class of hypolipidemic agents, used as pharmaceutical agents to lower cholesterol levels in people with or at risk for cardiovascular disease. ... This article is about the drug. ... Blood clot diagram. ...


One possible way to decrease risk of cardiovascular disease is keep your total cholesterol below 150. In the Framingham Heart Study, those with total cholesterol below 150 only very rarely got coronary heart disease. The Framingham Heart Study is a cardiovascular study based in Framingham, Massachusetts. ...


A magnesium deficiency, or lower levels of magnesium, can contribute to heart disease and a healthy diet that contains adequate magnesium may prevent heart disease.[10] Magnesium can be used to enhance long term treatment, so it may be effective in long term prevention.[11] Excess calcium may contribute to a buildup of calcium in the veins. Excess calcium can cause a magnesium deficiency, and magnesium can reduce excess calcium. Magnesium deficiency refers to an absolute lack of magnesium, the result of numerous conditions. ... General Name, symbol, number magnesium, Mg, 12 Chemical series alkaline earth metals Group, period, block 2, 3, s Appearance silvery white solid at room temp Standard atomic weight 24. ... Maintaining a healthy diet is the practice of making choices about what to eat with the intent of improving or maintaining good health. ... General Name, symbol, number magnesium, Mg, 12 Chemical series alkaline earth metals Group, period, block 2, 3, s Appearance silvery white solid at room temp Standard atomic weight 24. ... General Name, symbol, number magnesium, Mg, 12 Chemical series alkaline earth metals Group, period, block 2, 3, s Appearance silvery white solid at room temp Standard atomic weight 24. ... Magnesium deficiency refers to an absolute lack of magnesium, the result of numerous conditions. ... General Name, symbol, number magnesium, Mg, 12 Chemical series alkaline earth metals Group, period, block 2, 3, s Appearance silvery white solid at room temp Standard atomic weight 24. ...


Eating oily fish at least twice a week may help reduce the risk of sudden death and arrhythmias. A 2005 review of 97 clinical trials by Studer et al. noted that omega-3 fats gave lower risk ratios than did statins.[12] Olive oil is said to have benefits. Studies of individual heart cells showed that fatty acids blocked excessive sodium and calcium currents in the heart, which could otherwise cause dangerous, unpredictable changes in its rhythm. It has been suggested that this article or section be merged with Fish oil. ... For the Popeye character, see Olive Oyl. ... For sodium in the diet, see Edible salt. ... For other uses, see Calcium (disambiguation). ... The heart and lungs, from an older edition of Grays Anatomy. ...


[edit] Cardiovascular disease and salt

There is evidence from one large unblinded randomised controlled trial of more than 3000 patients that reducing the amount of sodium in the diet reduced the risk of cardiovascular events by more than 25%.[13] This re-affirms evidence from the Intersalt study published in 1996, that high levels of dietary salt are harmful;[14] these results were at the time heavily disputed by the Salt Institute (the salt producers' trade organisation).[15] The Intersalt study was a landmark observational study that showed a strong association between dietary salt and risk of cardiovascular disease. ...


[edit] Awareness

Atherosclerosis is a process that develops over decades and is often silent until an acute event (heart attack) develops in later life. Population based studies in the youth show that the precursors of heart disease start in adolescence. The process of atherosclerosis evolves over decades, and begins as early as childhood. The Pathobiological Determinants of Atherosclerosis in Youth Study demonstrated that intimal lesions appear in all the aortas and more than half of the right coronary arteries of youths aged 15–19 years. However, most adolescents are more concerned about other risks such as HIV, accidents, and cancer than cardiovascular disease.[16] This is extremely important considering that 1 in 3 people will die from complications attributable to atherosclerosis. In order to stem the tide of cardiovascular disease, primary prevention is needed. Primary prevention starts with education and awareness that cardiovascular disease poses the greatest threat and measures to prevent or reverse this disease must be taken.


[edit] Treatment

Treatment of cardiovascular disease depends on the specific form of the disease in each patient, but effective treatment always includes preventive lifestyle changes discussed above. Medications, such as blood pressure reducing medications, aspirin and the statin cholesterol-lowering drugs may be helpful. In some circumstances, surgery or angioplasty may be warranted to reopen, repair, or replace damaged blood vessels. Antihypertensives are a class of drugs that are used in medicine and pharmacology to treat hypertension (high blood pressure). ... Early in a coronary artery bypass surgery during vein harvesting from the legs (left of image) and the establishment of bypass (placement of the aortic cannula) (bottom of image). ... This article does not cite any references or sources. ...


[edit] Types of Cardiovascular Diseases

Aneurysms, Angina, Arrhythmia, Atherosclerosis, Cardiomyopathy, Cerebrovascular Disease, Congenital Heart Disease, Congestive Heart Failure, Myocarditis, Valve Disease, Coronary Artery Disease, Dilated cardiomyopathy, Diastolic Dysfunction, Endocarditis, High Blood Pressure (Hypertension), Hypertrophic Cardiomyopathy, Mitral valve prolapse, Myocardial Infarction (Heart Attack), Venous Thromboembolism. An aneurysm (or aneurism) (from Gr. ... angina tonsillaris see tonsillitis. ... A cardiac arrhythmia, also called cardiac dysrhythmia, is a disturbance in the regular rhythm of the heartbeat. ... Cerebrovascular disease is damage to the blood vessels in the brain, resulting in a stroke. ... Cross-section of a healthy heart. ... Congestive heart failure (CHF), also called congestive cardiac failure (CCF) or just heart failure, is a condition that can result from any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. ... In medicine (cardiology), myocarditis is inflammation of the myocardium, the muscular part of the heart. ... Wikipedia does not yet have an article with this exact name. ... Coronary heart disease (CHD), also called coronary artery disease (CAD) and atherosclerotic heart disease, is the end result of the accumulation of atheromatous plaques within the walls of the arteries that supply the myocardium (the muscle of the heart). ... Dilated cardiomyopathy or DCM (also known as congestive cardiomyopathy), is a disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is dilated, often without any obvious cause. ... Diastolic dysfunction refers to an abnormality in the hearts (i. ... Endocarditis is an inflammation of the inner layer of the heart, the endocardium. ... For other forms of hypertension, see Hypertension (disambiguation). ... Hypertrophic cardiomyopathy, or HCM, is a disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause. ... Mitral valve prolapse (MVP) is a heart valve condition marked by the displacement of an abnormally thickened mitral valve leaflet into the left atrium during systole. ... Acute myocardial infarction (AMI or MI), more commonly known as a heart attack, is a disease state that occurs when the blood supply to a part of the heart is interrupted. ... In the circulatory system, a vein is a blood vessel that carries blood toward the heart. ... Thrombosis is the formation of a clot or thrombus inside a blood vessel, obstructing the flow of blood through the circulatory system. ...


[edit] Research

The causes, prevention, and/or treatment of all forms of cardiovascular disease are active fields of biomedical research, with hundreds of scientific studies being published on a weekly basis. Biomedical Research involves thorough investigation of any matter related to the domain of living or biological Systems. ...


A fairly recent emphasis is on the link between low-grade inflammation that hallmarks atherosclerosis and its possible interventions. C-reactive protein (CRP) is an inflammatory marker that may be present in increased levels in the blood in patients at risk for cardiovascular disease. Its exact role in predicting disease is the subject of debate. An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... C-reactive protein (CRP) is a plasma protein, an acute phase protein produced by the liver. ...


Some areas currently being researched include possible links between infection with Chlamydophila pneumoniae and coronary artery disease. The Chlamydia link has become less plausible with the absence of improvement after antibiotic use.[17] An infection is the detrimental colonization of a host organism by a foreign species. ... Chlamydophila pneumoniae (previously known as Chlamydia pneumoniae) is a species of chlamydiae bacteria which infects humans and is a major cause of pneumonia. ...


[edit] References

  1. ^ United States (1999). Chronic Disease Overview. United States Government. Retrieved on 2007-02-07.
  2. ^ Rainwater DL, McMahan CA, Malcom GT, Scheer WD, Roheim PS, McGill HC Jr, Strong JP. Lipid and apolipoprotein predictors of atherosclerosis in youth: apolipoprotein concentrations do not materially improve prediction of arterial lesions in PDAY subjects. The PDAY Research Group. Arterioscler Thromb Vasc Biol. 1999; 19: 753-61.
  3. ^ Mcgill, HC, Jr., Mcmahan, CA, Zieske, AW et al. Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 1998–2004.
  4. ^ Jousilahti P, Vartiainen E, Tuomilehto J, Puska P (1999). "* Diabetes mellitus Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14,786 middle-aged men and women in Finland". CIRCULATION 99 (9): 1165-1172. PMID 10069784. 
  5. ^ Ho JE, Paultre F, Mosca L (2005). "The gender gap in coronary heart disease mortality: is there a difference between blacks and whites?". JOURNAL OF WOMEN'S HEALTH 14 (2): 117-127. PMID 15775729. 
  6. ^ Cook S, Togni M, Schaub MC, Wenaweser P, Hess OM (2006). "High heart rate: a cardiovascular risk factor?". Eur. Heart J. 27 (20): 2387-93. PMID 17000632. 
  7. ^ http://news.bbc.co.uk/1/hi/health/7035169.stm
  8. ^ Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ, Benjamin EJ, D'Agostino RB, Vasan RS (2006). "Multiple biomarkers for the prediction of first major cardiovascular events and death". N. Engl. J. Med. 355 (25): 2631-9. PMID 17182988. 
  9. ^ {{cite journal |author=Ramachandran Vasan, et al |journal=N. Engl. J.
  10. ^ Lack Energy? Maybe It's Your Magnesium Level
  11. ^ Comparison of Mechanism and Functional Effects of Magnesium and Statin Pharmaceuticals Andrea Rosanoff, PhD, Mildred S. Seelig, MD. Journal of the American College of Nutrition, Vol. 23, No. 5, 501S–505S (2004)
  12. ^ Studer M, Briel M, Liemenstoll B, Blass TR, Bucher HC. "Effect of different antilipidemic agents and diets on mortality: a systematic review." Arch. Intern. Med. 2005; 165(7): 725-730.
  13. ^ Cook NR, Cutler JA, Obarzanek E, et al. (2007). "Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)". Br Med J. doi:10.1136/bmj.39147.604896.55. 
  14. ^ Elliott P, Stamler J, Nichols R, et al. (1996). "Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group". Br Med J 312 (7041): 1249–53. PMID 8634612. 
  15. ^ Godlee F (2007). "Editor's Choice: Time to talk salt". Br Med J 334 (7599). doi:10.1136/bmj.39196.679537.47. 
  16. ^ Vanhecke TE, Miller WM, Franklin BA, Weber JE, McCullough PA. Awareness, knowledge, and perception of heart disease among adolescents. European Journal of Cardiovascular Prevention and Rehabilitation. October, 2006; 13(5): 718-723. ISSN 1741-8267
  17. ^ Andraws R, Berger JS, Brown DL. Effects of antibiotic therapy on outcomes of patients with coronary artery disease. JAMA 2005;293:2641-7. PMID 15928286.

Year 2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the AD/CE era in the 21st century. ... is the 38th day of the year in the Gregorian calendar. ... For the disease characterized by excretion of large amounts of very dilute urine, see diabetes insipidus. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... JAMA, published continuously since in 1883, is an international peer-reviewed general medical journal published 48 times per year. ...

[edit] External links


  Results from FactBites:
 
Cardiovascular disease - Wikipedia, the free encyclopedia (820 words)
Cardiovascular disease refers to the class of diseases that involve the heart and/or blood vessels (arteries and veins).
In practice, cardiovascular disease is treated by cardiologists, thoracic surgeons, vascular surgeons, neurologists, and interventional radiologists, depending on the organ system that is being treated.
The causes, prevention, and/or treatment of all forms of cardiovascular disease are active fields of biomedical research, with hundreds of scientific studies being published on a weekly basis.
Cardiovascular Disease - Print Version : Online Reference For Health Concerns (18145 words)
Cardiovascular disease is rarely caused by a single frailty.
In addition to causing cardiovascular disease by increasing the incidence of blood clots, hyperhomocysteinemia triggers atherosclerosis by encouraging smooth muscle cell proliferation, intimal-medial wall thickness, thromboxane A2 activity, lipid abnormalities, and the binding of Lp(a) to fibrin (Magott 1998; Sandrick 2000).
Although the incidence of hypertension, thrombotic stroke, peripheral vascular disease (gangrene), blood vessel toxicity, and the risk of heart attack escalate as homocysteine levels increase, homocysteine levels are not routinely evaluated in a cardiovascular work-up.
  More results at FactBites »