Carl Axel Setterberg (1812-1871) was an architect from Sweden. He studied to become an architect at the Swedish Art Academy in 1834-1841. In May of 1841, he got a job as building contractor in Gävleborg, where he worked the following ten years. When he heard that the city of Vaasa had burned down to the ground in 1852, he became interested in the opportunities surrounding the rebuilding of the city. He travelled to Vaasa where the job as county architect was open, and in January of 1853 he was temporarily appointed for the job after impressing the county governor Berndt Federley. In 1855 he was appointed permanently, after he had become a citizen of the Grand Duchy of Finland.

Carl Axel Setterberg became the creator of the new Vaasa. In 1854 he became the city architect and was comissioned with drawing up the new city plan on the isthmus of Klemetsö, a few kilometers away from the ruins of old Vaasa. He also designed many of the city's public and private buildings.

Setterberg died in Vaasa on January 7, 1871.