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During this period Carlisle suffered severely from the incursions of the Scots, and early in Henry III's reign we find the king complaining to the pope that Carlisle had revolted to Scotland, and that the canons had elected a bishop for themselves.
He disobeyed the queen openly when she forbade him to elevate the Sacred Host in her presence; he refused to appear at a disputation on religion, or to take the Oath of Supremacy, was deprived of his bishopric with the other Catholic bishops, and died a prisoner 31 December, 1559.
The cathedral was dedicated to the Blessed Virgin, though this was changed at the Reformation to the Holy Trinity.