Catenins are cadherin-binding molecules in mammalian cells. Beta-catenin binds cadherins on the cytoplasmic side. Alpha-catenin binds beta-catenin, and also binds actin. This functions to join cadherins to the cytoskeleton. An increase in Beta-catenin production has been noted in those people who have Basal Cell Carcinoma and leads the the increase in proliferation of related tumors. Cadherins are a class of proteins which are expressed on the surface of cells. ... Actin (red) profilin (blue) complex Actin is a globular protein that polymerizes helically forming actin filaments (or microfilaments), which like the other two components of the cellular cytoskeleton form a three-dimensional network inside an eukaryotic cell. ... The cytoskeleton is a cellular scaffolding or skeleton contained, as all other organelles, within the cytoplasm. ...