The little town of Cayce was named for James Hardie Cayce, who established stores in Moscow, Clinton, and Cayce. Cayce is centrally located in Kentucky's most westerly county, Fulton. Clinton is a city located in Hickman County, Kentucky. ... Fulton County is a county located in the state of Kentucky. ...

The community includes the area east and west from Willingham Bottom and Bayou de Chien Creek to Mud Creek and north and south from Moscow to the Middle Road (Ky. 166). Part of the town, known as the "junction" is at the junction of highways 94 and 293. This is the location of the service stations and cafe.

In the late 1800's and early 1900's Cayce was a thriving southern business town. Today, however it is a residential small town.