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Encyclopedia > Celecoxib
Celecoxib
Systematic (IUPAC) name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)
pyrazol-1-yl]benzenesulfonamide
Identifiers
CAS number 169590-42-5
ATC code L01XX33 M01AH01
PubChem 2662
DrugBank APRD00373
Chemical data
Formula C17H14F3N3O2S 
Mol. mass 381.373 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 40%
Protein binding 97% (mainly to serum albumin)
Metabolism Hepatic (mainly CYP2C9)
Half life ~11 hours
Excretion Renal 27%, faecal 57%
Therapeutic considerations
Pregnancy cat.

B3(AU) C(US) IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... For other uses, see Carbon (disambiguation). ... This article is about the chemistry of hydrogen. ... Distinguished from fluorene and fluorone. ... General Name, symbol, number nitrogen, N, 7 Chemical series nonmetals Group, period, block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... This article is about the chemical element and its most stable form, or dioxygen. ... This article is about the chemical element. ... The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... A drugs efficacy may be affected by the degree to which it binds to the proteins within blood plasma. ... You may be looking for albumen, or egg white. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... Cytochrome P450 2C9 (abbreviated CYP2C9), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. ... The biological half-life of a substance is the time required for half of that substance to be removed from an organism by either a physical or a chemical process. ... The kidneys are important excretory organs in vertebrates. ... Horse feces Feces, faeces, or fæces (see spelling differences) is a waste product from an animals digestive tract expelled through the anus (or cloaca) during defecation. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... For other uses, see Australia (disambiguation). ... For other uses of terms redirecting here, see US (disambiguation), USA (disambiguation), and United States (disambiguation) Motto In God We Trust(since 1956) (From Many, One; Latin, traditional) Anthem The Star-Spangled Banner Capital Washington, D.C. Largest city New York City National language English (de facto)1 Demonym American...

Legal status

℞ Prescription only The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Routes Oral

Celecoxib (INN) (pronounced /sɛlɨˈkɒksɪb/) is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. ... An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Osteoarthritis (OA, also known as degenerative arthritis, degenerative joint disease, or in more colloquial terms wear and tear), is a condition in which low-grade inflammation results in pain in the joints, caused by wearing of the cartilage that covers and acts as a cushion inside joints and destruction or... Rheumatoid arthritis (RA) is traditionally considered a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ... Pain is both a sensory and emotional experience, generally associated tissue damage, or inflammation. ... Not to be confused with Mensuration. ... Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine. ... Pfizer Incorporated (NYSE: PFE) is a major pharmaceutical company, which ranks number one in the world in sales[2]. The company is based in New York City. ... This article is about brands in marketing. ... A medical prescription ) is an order (often in written form) by a qualified health care professional to a pharmacist or other therapist for a treatment to be provided to their patient. ...

Contents

Indications

Celecoxib is licensed for use in osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce the number of colon and rectal polyps in patients with familial adenomatous polyposis. It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects usually seen with conventional NSAIDs. In practice, its primary indication is in patients who need regular and long term pain relief: there is probably no advantage to using celecoxib for short term or acute pain relief over conventional NSAIDs. In particular, the pain relief offered by celecoxib is similar to that offered by paracetamol.[1] Osteoarthritis (OA, also known as degenerative arthritis, degenerative joint disease, or in more colloquial terms wear and tear), is a condition in which low-grade inflammation results in pain in the joints, caused by wearing of the cartilage that covers and acts as a cushion inside joints and destruction or... Rheumatoid arthritis (RA) is traditionally considered a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ... Pain is both a sensory and emotional experience, generally associated tissue damage, or inflammation. ... Not to be confused with Mensuration. ... Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Paracetamol (INN) (IPA: ) or acetaminophen (USAN), is the active metabolite of phenacetin, a so-called coal tar analgesic. ...


Availability

Pfizer sells Celecoxib under the brand name Celebrex. Celecoxib is not currently available generically in the United States, because the intellectual property is still controlled by Pfizer. Generic Celecoxib pills are produced legally in some countries and illegally in others, and are often sold to customers in the United States and elsewhere through web-based stores. Pfizer Incorporated (NYSE: PFE) is a major pharmaceutical company, which ranks number one in the world in sales[2]. The company is based in New York City. ... This article is about brands in marketing. ...


Pharmacology

Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (inhibition of prostaglandin production), whereas traditional NSAIDs inhibit both COX-1 and COX-2. Celecoxib is approximately 7.6 times more selective for COX-2 inhibition over COX-1. In theory, this specificity allows celecoxib and other COX-2 inhibitors to reduce inflammation (and pain) while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective NSAIDs. Cyclooxygenase (COX) is an enzyme that is responsible for formation of important biological mediators called prostanoids (including prostaglandins, prostacyclin and thromboxane). ... Cyclooxygenase (COX) is an enzyme (EC 1. ... Cyclooxygenase (COX) is an enzyme (EC 1. ... An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... An adverse drug reaction (abbreviated ADR) is a term to describe the unwanted, negative consequences sometimes associated with the use of medications. ... Peptic ulcer is a non-malignant ulcer of the stomach (called gastric ulcer) or duodenum (called duodenal ulcer). ...


Dosing

The usual adult dose of celecoxib is 100 to 200mg once or twice a day. The lowest effective dose should be used.


Adverse effects

Main article: Non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ...

Gastrointestinal ADRs

In theory the COX-2 selectivity should result in a significantly lower incidence of gastrointestinal ulceration than traditional NSAIDs. The main body of evidence touted to support this theory were the preliminary (6 month) results of the Celecoxib Long-term Arthritis Safety Study (CLASS) as published in 2000, which demonstrated a significant reduction in the combination of symptomatic ulcers plus ulcer complications in those taking celecoxib versus ibuprofen or diclofenac, provided they were not on aspirin (Silverstein et al, 2000). However, this was not significant at 12 months (full study length). It should be noted that this study used a very high dose of Celebrex, 800mg daily (400mg twice a day). Year 2000 (MM) was a leap year starting on Saturday (link will display full 2000 Gregorian calendar). ... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom... my sister died form overdose!!! Diclofenac (marketed as Voltaren, Voltarol, Diclon, Dicloflex Difen, Difene, Cataflam, Pennsaid, Rhumalgan, Modifenac, Abitren and Zolterol) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and an analgesic reducing pain in conditions such as in arthritis or acute injury. ...


Allergy

Celecoxib contains a sulfonamide moiety and may cause allergic reactions in those allergic to other sulfonamide-containing drugs. This is in addition to the contraindication in patients with severe allergies to other NSAIDs. In chemistry, the sulfonamide functional group is -S(=O)2-NH2, a sulfone group connected to an amine group. ...


Risk of heart attack and stroke

There has been much concern about the possibility of increased risk for heart attack and stroke in users of NSAID drugs, particularly COX-2 selective NSAIDs such as celecoxib, since the withdrawal of the COX-2 inhibitor rofecoxib (Vioxx) in 2004. Like all NSAIDs on the U.S. market, celecoxib carries an FDA-mandated "black box warning" for cardiovascular and gastrointestinal risk. In February 2007, the American Heart Association warned that celecoxib should be used "as a last resort on patients who have heart disease or a risk of developing it", and suggested that paracetamol, or certain older NSAIDs, such as naproxen, may be safer choices for pain relief in these patients.[2] Rofecoxib (IPA: ) is a nonsteroidal anti-inflammatory drug (NSAID) developed by Merck & Co. ... The American Heart Association (AHA) is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke American Stroke Association Web site. ... Paracetamol (INN) (IPA: ) or acetaminophen (USAN), is the active metabolite of phenacetin, a so-called coal tar analgesic. ... Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary...


The cardiovascular risks of celecoxib are controversial, with apparently contradictory data produced from different clinical trials. In December of 2004, "APC," the first of two trials of celecoxib for colon cancer prevention, found that long-term (33 months) use of high-dose Celebrex (400 and 800mg daily) demonstrated an increased cardiovascular risk compared with placebo.[3] A similar trial, named PreSAP, did not demonstrate an increased risk.[4] Still, the APC trial, combined with the recent Vioxx findings, suggested that there might be serious cardiovascular risks specific to the COX-2 inhibitors. On the other hand, a large Alzheimers prevention trial, called ADAPT, was terminated early after preliminary data suggested that the nonselective NSAID naproxen, but not celecoxib, was associated with increased cardiovascular risk.[5] In April 2005, after an extensive review of data, the FDA concluded that it was likely "that there is a 'class effect' for increased CV risk for all NSAIDs."[6] Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary...


Two studies on the cardiovascular risks of celecoxib and other NSAIDs were meta-analyses, published in 2006. The first of these, published in the British Medical Journal, looked at the incidence of cardiovascular events in all previous randomized controlled trials of COX-2 inhibitors, as well as some trials of other NSAIDs. The authors concluded that a significant increased risk did exist for celecoxib, as well as some other selective and nonselective NSAIDS. However, the increased cardiovascular risk in celecoxib was only noted at daily doses of 400 mg or greater. [7] A second meta-analysis published in the Journal of the American Medical Association, which included observational rather than randomized studies (mostly at lower doses) did not find an increased cardiovascular risk of celecoxib vs placebo.[8] A meta-analysis is a statistical practice of combining the results of a number of studies. ... The British Medical Journal (BMJ) is a medical journal published weekly in the United Kingdom by the British Medical Association (BMA)which published its first issue in 1845. ... A randomized controlled trial (RCT) is a form of clinical trial, or scientific procedure used in the testing of the efficacy of medicine, used because of its record of reliability. ... JAMA, published continuously since in 1883, is an international peer-reviewed general medical journal published 48 times per year. ...


To more conclusively establish the true cardiovascular risk profile of celecoxib, Pfizer has agreed to fund a large, randomized trial specifically designed for that purpose. The trial, centered at the Cleveland Clinic, has a planned enrollment of 20,000 high-risk patients. Celecoxib will be compared to the non-selective NSAIDS naproxen and ibuprofen.[9] Since all patients have arthritis, ethical considerations make it difficult to have a placebo group. This trial has just begun enrollment according to the Clinical Trials database, and is not scheduled to be completed until 2010. Ultimately, this trial will help answer the question as to whether Celebrex has a riskier cardiovascular profile compared to naproxen or ibuprofen. Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom...


History

Celecoxib was developed by G. D. Searle & Company and co-promoted by Monsanto (parent company of Searle) and Pfizer under the brand name Celebrex. Monsanto merged with Pharmacia, from which the Medical Research Division was acquired by Pfizer, giving Pfizer ownership of Celebrex. The drug was at the core of a major patent dispute that was resolved in Searle's favor (later Pfizer) in 2004. In University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004), the University of Rochester claimed that United States Pat. No. 6,048,850 (which claimed a method of inhibiting COX-2 in humans using a compound, without actually disclosing what that compound might be) covered drugs such as celecoxib. The court ruled in favor of Searle, holding in essence that the University had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2 and therefore the patent was invalid. G.D. Searle & Company was a company focusing on life sciences, specifically pharmaceuticals, agriculture, and animal health. ... The Monsanto Company (NYSE: MON) is a multinational agricultural biotechnology corporation. ... Pfizer Incorporated (NYSE: PFE) is a major pharmaceutical company, which ranks number one in the world in sales[2]. The company is based in New York City. ... Pharmacia was originally a government owned Swedish pharmaceutical company. ... The University of Rochester (UR) is a private, coeducational and nonsectarian research university located in Rochester, New York. ...


After the withdrawal of rofecoxib (Vioxx) from the market in September 2004, Celebrex enjoyed a robust increase in sales. However, the results of the APC trial in December of that year raised concerns that Celebrex might carry risks similar to those of Vioxx, and Pfizer announced a moratorium on direct-to-consumer advertising of Celebrex soon afterwards. After a significant drop, sales of Celebrex have recovered, and reached $2 billion in 2006.[2] Pfizer resumed advertising Celebrex in magazines in 2006,[10] and resumed television advertising in April of 2007 with an unorthodox, 2 1/2 minute advertisement which extensively discussed the adverse effects of Celebrex in comparison to other anti-inflammatory drugs. The ad drew criticism from the consumer advocacy group Public Citizen, which called the ad's comparisons misleading.[11] Pfizer has responded to Public Citizens concerns with assurances that they are truthfully advertising the risk and benefits of Celebrex as set forth by the FDA. Public Citizen is a U.S. non-governmental organization, founded by Ralph Nader in 1971 and based in Washington, DC. Its activities span across a diverse range of issues, including energy policy, trade policy, campaign finance reform and accountability, consumer protection, medical malpractice, and public health. ...


In late 2007, Pfizer released another US television ad for Celebrex, which also discussed Celecoxib's adverse effects in comparison to other anti-inflammatory drugs.


Research into cancer prevention

The role that celecoxib might have in reducing the rates of certain cancers has been the subject of many studies. However, given the side effects of anti-COX-2 on rates of heart disease, there is no current medical recommendation to use this drug for cancer reduction.

  • Colorectal cancer risk is clearly reduced in people regularly taking a NSAID like aspirin or celecoxib. In addition, some epidemiological studies, and most preclinical studies pointed out that specific COX-2 inhibitors like celecoxib are more potent and less toxic than "older" NSAIDs. Twelve carcinogenesis studies support that celecoxib is strikingly potent to prevent intestinal cancer in rats or mice (data available on the Chemoprevention Database). Small-scale clinical trials in very high risk people (belonging to FAP families) also indicate that celecoxib can prevent polyp growth. Hence large-scale randomized clinical trials were undertaken and results published by N.Arber and M.Bertagnolli in the New England Journal of Medicine, August 2006[3] Results show a 33 to 45% polyp recurrence reduction in people taking 0.4-0.8 g celecoxib each day. However, serious cardiovascular events were significantly more frequent in the celecoxib treated groups (see above, cardiovascular toxicity). Aspirin shows a similar (and possibly larger) protective effect,[12][13][14] has demonstrated cardioprotective effects and is significantly cheaper, but there have been no head-to-head clinical trials comparing the two drugs.

Colorectal cancer, also called colon cancer or bowel cancer, includes cancerous growths in the colon, rectum and appendix. ... This article is about the drug. ...

References

  • Malhotra S, Shafiq N, Pandhi P (2004). COX-2 inhibitors: a CLASS act or Just VIGORously promoted. MedGenMed 6 (1), 6. PMID 15208519
  • Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al (2000). Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. The CLASS study: a randomized controlled trial. JAMA 284 (10), 1247-55. PMID 10979111
  • Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al (2005). Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 352 (11), 1071-80. PMID 15713944

Footnotes

  1. ^ Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM (2007). "Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials". Rheumatology 46: 135–40. PMID 16777855. 
  2. ^ a b CNBC.com (Feb 26, 2007). Pfizer's Celebrex Should Be 'Last Resort,' Heart Group Says. CNBC.com.
  3. ^ Bertagnolli M, Eagle C, Zauber A, Redston M, Solomon S, Kim K, Tang J, Rosenstein R, Wittes J, Corle D, Hess T, Woloj G, Boisserie F, Anderson W, Viner J, Bagheri D, Burn J, Chung D, Dewar T, Foley T, Hoffman N, Macrae F, Pruitt R, Saltzman J, Salzberg B, Sylwestrowicz T, Gordon G, Hawk E (2006). "Celecoxib for the prevention of sporadic colorectal adenomas.". N Engl J Med 355 (9): 873-84. PMID 16943400. 
  4. ^ Arber N, Eagle C, Spicak J, Rácz I, Dite P, Hajer J, Zavoral M, Lechuga M, Gerletti P, Tang J, Rosenstein R, Macdonald K, Bhadra P, Fowler R, Wittes J, Zauber A, Solomon S, Levin B (2006). "Celecoxib for the prevention of colorectal adenomatous polyps.". N Engl J Med 355 (9): 885-95. PMID 16943401. 
  5. ^ ADAPT Research Group. Public Library of Science (PloS) Clinical Trials 2006;e33:1-10.
  6. ^ Jenkins JK, Seligman PJ. (April 6, 2005). Analysis and recommendations for Agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk [decision memorandum] (PDF). FDA Center for Drug Evaluation and Research.
  7. ^ Kearney P, Baigent C, Godwin J, Halls H, Emberson J, Patrono C (2006). "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials". BMJ 332 (7553): 1302-8. PMID 16740558. 
  8. ^ McGettigan P, Henry D (2006). "Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.". JAMA 296 (13): 1633-44. PMID 16968831. 
  9. ^ PRECISION : Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen Or Naproxen. ClinicalTrials.gov. National Library of Medicine (December 7, 2006).
  10. ^ [1] Berenson A. Celebrex Ads Are Back, Dire Warnings and All. (April 29, 2006) New York Times.
  11. ^ [2] Saul S. Celebrex Commercial, Long and Unconventional, Draws Criticism. (April 10, 2007) New York Times.
  12. ^ Baron JA, Cole BF, Sandler RS, et al. (2003). "A randomized trial of aspirin to prevent colorectal adenomas". N Engl J Med 348: 891–899. PMID 12621133. 
  13. ^ Sandler RS, Halabi S, Baron JA, et al. (2003). "A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer". N Engl J Med 348: 883–90. PMID 12621132. 
  14. ^ Bosetti C, Talamini R, Franceschi S, Negri E, Garavello W, La Vecchia C (2003). "Aspirin use and cancers of the upper aerodigestive tract". Brit J Cancer 88: 672-674. doi:10.1038/sj.bjc.6600820. 

A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ...

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See also: NSAIDs		 Pyrazolidine/Butylpyrazolidines: · Ampyrone · Clofezone · Kebuzone · Metamizole · Mofebutazone · Oxyphenbutazone · Phenazone · Phenylbutazone · Sulfinpyrazone ·

Acetic acid derivatives and related substances: · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Bumadizone · Bufexamac · Diclofenac · Difenpiramide · Etodolac · Fentiazac · Indometacin · Ketorolac · Lonazolac · Oxametacin · Proglumetacin · Sulindac · Tolmetin · Zomepirac · Pfizer Incorporated (NYSE: PFE) is a major pharmaceutical company, which ranks number one in the world in sales[2]. The company is based in New York City. ... December 17 is the 351st day of the year (352nd in leap years) in the Gregorian calendar. ... Year 2004 (MMIV) was a leap year starting on Thursday of the Gregorian calendar. ... Chemotherapy, in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer. ... A section of the Anatomical Therapeutic Chemical Classification System. ... An alkylating antineoplastic agent is an alkylating agent that attaches an alkyl group to DNA. Since cancer cells generally divide more rapidly than do healthy cells they are more sensitive to DNA damage, and alkylating agents are used clinically to treat a variety of tumours. ... The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. ... Chlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. ... Mechloretamine: chemical structure Mechlorethamine also known as nitrogen mustard and HN2 and sold under the brand name Mustargen, is the first anticancer drug to be widely used clinically. ... Cyclophosphamide (the generic name for Cytoxan, Neosar) is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders. ... Ifosfamide (Mitoxana®) Ifosfamide (pronounced i fos fa mide) is chemotherapy that is given as a treatment for many different types of cancer. ... Melphalan hydrochloride ( Alkeran®) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. ... Uracil mustard or uramustine is a chemotherapy drug which belongs to the class of alkylating agents. ... Urea streptozotocin ENU Nitrosourea compounds are compounds that include a nitroso (R-NO) group and a urea. ... Carmustine is an nitrosourea compound used as an alkylating agent in chemotherapy. ... Fotemustine is a nitrosourea alkylating agent. ... Lomustine (or CCNU) is an alkylating nitrosourea compound used in chemotherapy. ... Streptozotocin (STZ, Zanosar) is a drug used in treating cancer of the pancreas. ... General Name, Symbol, Number platinum, Pt, 78 Chemical series transition metals Group, Period, Block 10, 6, d Appearance grayish white Standard atomic weight 195. ... Carboplatin is a chemotherapy drug used against some forms of cancer. ... Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e. ... Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. ... There are very few or no other articles that link to this one. ... Busulfan is a chemotherapy drug that is an alkylating agent (slows the growth of cancer cells). ... Hydrazine is the chemical compound with formula N2H4. ... Procarbazine (Matulane® (US), Natulan (Canada)) is an antineoplastic chemotherapy drug for the treatment of Hodgkins lymphoma and certain brain cancers (such as Glioblastoma multiforme). ... Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma (a form of skin cancer which can spread to other parts of the body). ... Temozolomide (brand name Temodar® Schering-Plough Corporation) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. ... Aziridine parent compound Aziridines are a group of organic compounds sharing the aziridine functional group which is a three membered heterocycle with one amine group and two methylene groups 1,2. ... N,NN-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. ... An antimetabolite is a chemical with a similar structure to a substance (a metabolite) required for normal biochemical reactions, yet different enough to interfere with the normal functions of cells, including cell division. ... Folic acid and folate (the anion form) are forms of the water-soluble Vitamin B9. ... Aminopterin (4-aminopteroic acid), a 4-amino analog of folic acid, is an antineoplastic drug with immunosuppressive properties used in chemotherapy. ... Amethopterin redirects here. ... Pemetrexed chemical structure Pemetrexed (brand name Alimta) is a chemotherapy drug. ... Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. ... Purine (1) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. ... Cladribine is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis). ... Clofarabine: chemical structure Clofarabine is a substance that is being studied in the treatment of cancer. ... Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. ... Mercaptopurine: chemical structure Mercaptopurine (also called 6-MP or by its brand name Purinethol®) is an immunosuppressive drug used to treat leukemia. ... Pentostatin (Deoxycoformycin) is an anticancer chemotherapeutic drug. ... Tioguanine (INN), formerly Thioguanine (BAN), is a drug that is used in the treatment of cancer. ... Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring [1]. It is isomeric with two other forms of diazine. ... Capecitabine (INN) (IPA: ) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. ... Cytarabine is a shortened form of cytosine arabinoside, a commonly used chemotherapy agent used mainly in the treatment of leukemia and non-Hodgkin lymphoma. ... Decitabine (Dacogen®), or 5-aza-2-deoxy-cytidine, is indicated for treatment of patients with myelodysplastic syndrome (MDS), including previously treated and untreated, de novo, and secondary MDS of all FAB subtypes and Intermediate-1, Intermediate-2, and High-Risk IPSS groups. ... Fluorouracil (5-FU) is a drug that is used in the treatment of cancer. ... Floxuridine is an oncology drug that belongs to the class known as antimetabolites. ... Gemcitabine is a nucleoside used as chemotherapy. ... These poisons disrupt cellular reproduction by affecting the protein threads which connect the centromere regions of chromosomes, known as spindles. ... A mitotic inhibitor is a type of drug used mainly to treat cancer. ... The taxanes are NOT alkaloids (not every molecule coming from a plant and bearing a nitrogen is an alkaloid!). They are diterpenes produced by the plants of the genus Taxus (yews). ... Docetaxel chemical structure Docetaxel is a chemotherapy drug used in the treatment of cancer. ... Paclitaxel is a drug used in the treatment of cancer. ... Vinca is Vinca, a botanical genus; see Periwinkle (plant). ... Vinblastine stick molecular model Vinblastine is an anti-mitotic drug used to treat certain kinds of cancer, including Hodgkins lymphoma, non-small cell lung cancer, breast cancer and testicular cancer. ... Vincristine (Oncovin®), also known as leurocristine, is a vinca alkaloid from the Madagascar periwinkle (Catharanthus roseus, formerly Vinca rosea and hence its name). ... Vindesine is a vinca alkaloid used in chemotherapy. ... Vinorelbine (Navelbine) is a chemotherapy drug that is given as a treatment for some types of cancer including breast cancer and non-small-cell lung cancer. ... herbs that have the specific action of inhibiting and combating the development of tumors. ... Anthracycline - Wikipedia, the free encyclopedia /**/ @import /skins-1. ... Daunorubicin or daunomycin (daunomycin cerubidine) is chemotherapy of the anthracycline family that is given as a treatment for some types of cancer. ... Doxorubicin or Adriamycin® or hydroxyldaunorubicin is a DNA-interacting drug widely used in chemotherapy. ... Epirubicin (marketed by Pfizer under the trade name Ellence®) is an anthracycline drug used for chemotherapy. ... Idarubicin chemical structure Idarubicin or 4-demethoxydaunorubicin is an anthracycline drug that is used in the treatment of cancer. ... Mitoxantrone belongs to the general group of medicines known as antineoplastics, specifically the anthracycline class. ... Valrubicin chemical structure Valrubicin (N-trifluoroacetyladriamycin-14-valerate, Valstar®) is a chemotherapy drug used to treat bladder cancer. ... Streptomyces is a genus of Actinobacteria. ... Actinomycin is any of a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. ... Bleomycin is an anti-cancer agent. ... Mitomycin or mitomycin C is a form of chemotherapy given intravenously to treat upper gastro-intestinal (e. ... Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus. ... Hydroxyurea chemical structure Hydroxyurea or hydroxycarbamide (rINN), (brand names include Hydrea®) is an antineoplastic drug used in hematological malignancies. ... Topoisomerase inhibitors are chemotherapy agents designed to interfere with the action of topoisomerase enzymes (topoisomerase I and II), which are enzymes that control the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. ... Species Camptotheca acuminata - Happy tree Camptotheca lowreyana The Happy tree, Camptotheca acuminata, is a medium-sized deciduous tree native to central China, usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. ... Camptothecin is a plant secondary metabolite used as an anti-cancer drug that damages DNA, leading to the destruction of the cell. ... Topotecan (Hycamtin®) is a chemotherapy agent that is a topoisomerase 1 inhibitor. ... Irinotecan is a chemotherapy agent that is a topoisomerase 1 inhibitor. ... Binomial name Podophyllum peltatum L. The American Mayapple (Podophyllum peltatum) is a herbaceous perennial plant in the family Berberidaceae, native to the eastern part of North America. ... Etoposide phosphate (Eposin®, Etopophos®, Vepesid®, VP-16®) is an inhibitor of the enzyme topoisomerase II. It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. ... Teniposide is a prescribed medication mainly used to treat childhood acute lymphocytic leukemia. ... Cancer Immunotherapy is the use of monoclonal antibodies (-mab) to specifically target cells. ... // Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell and are all clones of a single parent cell. ... Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. ... Cetuximab (Erbitux®) is a chimeric monoclonal antibody given by intravenous injection for treatment of colorectal cancer. ... It is proposed that this article be deleted, because of the following concern: No references or indication of notability. ... Trastuzumab (more commonly known under the trade name Herceptin) is a humanized monoclonal antibody that acts on the HER2/neu (erbB2) receptor. ... CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells. ... Rituximab, sold under the trade names Rituxan® and MabThera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkins lymphoma, B cell leukemia, and some autoimmune disorders. ... Tositumomab is a monoclonal antibody. ... Alemtuzumab (marketed as Campath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL) and T-cell lymphoma. ... Bevacizumab (trade name Avastin) is a monoclonal antibody against vascular endothelial growth factor. ... Gemtuzumab ozogamicin (marketed as Mylotarg) is a monoclonal antibody used to treat acute myelogenous leukemia. ... A photosensitizer is a chemical compound, used in the Photodynamic Therapy of cancers, that can be excited by light of a specific wavelength. ... D-Aminolevulinic acid (dALA or δ-ALA) is the first compound in the porphyrin synthesis pathway. ... Methyl aminolevulinate is a sensitizer used in photodynamic/radiation therapy. ... Porfimer is a sensitizer used in photodynamic/Radiation therapy. ... Verteporfin, otherwise known as benzoporphyrin derivative (Visudyne®), is a medication used in conjunction with laser treatment to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. ... Tyrosine kinases are a subclass of protein kinase, see there for the principles of protein phosphorylation A tyrosine kinase (EC 2. ... A protein kinase inhibitor is a type of enzyme inhibitor which specifically blocks the action of protein kinase. ... Dasatinib, also known as BMS-354825, is a drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel®. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitor approved for use in patients with chronic myelogenous leukemia (CML) after imatinib treatment and Philadelphia chromosome... Erlotinib hydrochloride (trade name Tarceva, Genentech/OSIP, originally coded as OSI-774) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. ... Gefitinib is a new drug used in the treatment of certain types of cancer. ... Imatinib is a drug used to treat certain types of cancer. ... Lapatinib (INN) or lapatinib ditosylate (USAN), also known as GW572016, is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. ... There are very few or no other articles that link to this one. ... Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). ... Sunitinib (marketed as Sutent, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. ... Vandetanib (rINN, trade name Zactima®), also known as ZD6474, is a medication currently undergoing clinical trials as a potential targeted treatment for non–small-cell lung cancer. ... First- and second-generation retinoid compounds The retinoids are a class of chemical compounds that are related chemically to vitamin A. Retinoids are used in medicine, primarily due to the way they regulate epithelial cell growth. ... Alitretinoin is an antineoplastic agent. ... Tretinoin is the acid form of vitamin A and so also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. ... Altretamine (also hexalen) is a drug that is used to treat ovarian cancer. ... Amsacrine is an antineoplastic agent. ... Anagrelide (Agrylin®/Xagrid®, Shire) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). ... R-phrases , , , S-phrases , , , Supplementary data page Structure and properties n, εr, etc. ... Asparaginase (EC 3. ... Pegaspargase is an antineoplastic agent. ... Bexarotene is an antineoplastic agent. ... Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. ... Denileukin diftitox is an antineoplastic agent. ... Estramustine (Emcyt®) is a chemotherapy agent used to treat prostate cancer. ... Masoprocol is an antineoplastic agent. ... Mitotane is a substance used for the rare disease adrenocortical carcinoma. ... Tipifarnib is being investigated in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). ... Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. ... Disease-modifying antirheumatic drugs is a category of drugs used in many autoimmune diseases to slow down disease progression. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... Pyrazolidine is a heterocyclic compound. ... Clofezone is a drug used for joint and muscular pain. ... Kebuzone (or ketophenylbutazone) is a non-steroidal anti-inflammatory drug. ... Not to be confused with methimazole . ... Mofebutazone (or monophenylbutazone) is a drug used for joint and muscular pain. ... Phenylbutazone, often referred to as bute, is a crystalline substance having the structure shown at right. ... Phenazone, or phenazon, is an analgesic. ... Phenylbutazone, often known as bute, is a crystalline substance having the structure shown at right. ... Sulfinpyrazone is a uricosuric medication used to treat gout. ... R-phrases , S-phrases , , , Flash point 43 °C Related Compounds Related carboxylic; acids Formic acid; Propionic acid; Butyric acid Related compounds acetamide; ethyl acetate; acetyl chloride; acetic anhydride; acetonitrile; acetaldehyde; ethanol; thioacetic acid; acetylcholine; acetylcholinesterase Supplementary data page Structure and properties n, εr, etc. ... Aceclofenac is a non-steroidal anti-inflammatory drug. ... Acemetacin is a non-steroidal anti-inflammatory drug. ... Alclofenac is a non-steroidal anti-inflammatory drug. ... Bumadizone is a non-steroidal anti-inflammatory drug. ... Bufexamac is a drug used for joint and muscular pain. ... my sister died form overdose!!! Diclofenac (marketed as Voltaren, Voltarol, Diclon, Dicloflex Difen, Difene, Cataflam, Pennsaid, Rhumalgan, Modifenac, Abitren and Zolterol) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and an analgesic reducing pain in conditions such as in arthritis or acute injury. ... Difenpiramide is a non-steroidal anti-inflammatory drug. ... Etodolac is the International Nonproprietary Name (INN) of 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid (empirical formula C17H21NO3), also sold under the trade name Lodine. ... Fentiazac is a drug used for joint and muscular pain. ... Indometacin (INN) or Indomethacin (USAN and former BAN) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ... Ketorolac or ketorolac tromethamine (marketed as Toradol - generics have been approved) is a non-steroidal anti-inflammatory drug (NSAID) in the family of propionic acids, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. ... Lonazolac is a non-steroidal anti-inflammatory drug. ... Oxametacin (or oxamethacin) is a non-steroidal anti-inflammatory drug. ... Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. ... Sulindac is a non-steroidal anti-inflammatory drug of the arylalkanoic acid class that is marketed in the U.S. as Clinoril. ... Tolmetin (IPA: ) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. ... Zomepirac Sodium is an orally effective NSAID that has antipyretic actions. ...


Oxicams: · Droxicam · Lornoxicam · Meloxicam · Piroxicam · Tenoxicam · Piroxicam Meloxicam An oxicam is a class of non-steroidal anti-inflammatory drugs which binds closely to plasma proteins. ... Droxicam is a non-steroidal anti-inflammatory drug. ... Lornoxicam is a non-steroidal anti-inflammatory drug. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of Rheumatoid and Osteoarthritis, primary dysmenorrhoea, Post Operative Pain; and act as an analgesic, especially where there is an inflammatory component. ... Tenoxicam is a non-steroidal anti-inflammatory drug. ...


Propionic acid derivatives: · Alminoprofen · Benoxaprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuprofen · Ibuproxam · Indoprofen · Ketoprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tiaprofenic acid · Propionic acid (systematically named propanoic acid) is a naturally occurring carboxylic acid with chemical formula CH3CH2COOH. In the pure state, it is a colorless, corrosive liquid with a pungent odor. ... Alminoprofen is a non-steroidal anti-inflammatory drug. ... Benoxaprofen is a non-steroidal anti-inflammatory drug. ... Dexibuprofen is a non-steroidal anti-inflammatory drug. ... Dexketoprofen is a non-steroidal anti-inflammatory drug. ... Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. ... Fenoprofen is a non-steroidal anti-inflammatory drug. ... Flunoxaprofen is a non-steroidal anti-inflammatory drug. ... Flurbiprofen is an NSAID (non-steroidal anti-inflammatory drug) used to treat the inflammation and pain of arthritis. ... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom... Ibuproxam is a non-steroidal anti-inflammatory drug. ... Indoprofen is a non-steroidal anti-inflammatory drug. ... Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. ... Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary... Oxaprozin (brand name: Daypro®) is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. ... Pirprofen is a non-steroidal anti-inflammatory drug. ... Suprofen is an NSAID marketed in a 1% solution under the trade name Profenal. ... Tiaprofenic acid is pharmaceutical, belonging to the class called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat pain, especially arthritic pain. ...


Fenamates: · Flufenamic acid · Meclofenamic acid · Mefenamic acid · Tolfenamic acid · Fenamic acid is a molecule which serves as a parent structure for several non-steroidal anti-inflammatory drugs, including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. ... Flufenamic acid is a non-steroidal anti-inflammatory drug. ... Meclofenamic acid is a drug used for joint and muscular pain. ... Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. ... Tolfenamic acid (TA) is one of the class of non steroidal anti-inflammatory drugs (NSAIDs). ...


Coxibs: · Celecoxib · Etoricoxib · Lumiracoxib · Parecoxib · Rofecoxib · Valdecoxib · COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. ... Etoricoxib (brand name Arcoxia®) is a new COX-2 selective inhibitor from Merck & Co. ... Lumiracoxib (rINN) is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug, manufactured by Novartis and sold in 21 countries, including the United Kingdom, Mexico, Germany, South Africa, Australia, Argentina and Brazil, under the trade name Prexige® (sometimes misquoted as Prestige by the media). ... Injectible prodrug of valdecoxib. ... Rofecoxib (IPA: ) is a nonsteroidal anti-inflammatory drug (NSAID) developed by Merck & Co. ... Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. ...

other anti-inflammatory and antirheumatic agents, non-steroids: · Nabumetone · Niflumic acid · Azapropazone · Glucosamine · Benzydamine · Glycosaminoglycan · Magnesium salicylate · Proquazone · Superoxide dismutase/Orgotein · Nimesulide · Feprazone · Diacerein · Morniflumate · Tenidap · Oxaceprol · Chondroitin sulfate ·
Specific antirheumatic
agents		 Quinolines: · Oxycinchophen ·

Gold preparations: · Sodium aurothiomalate · Sodium aurothiosulfate · Auranofin · Aurothioglucose · Aurotioprol · Nabumetone is a non-steroidal anti-inflammatory drug of the arylalkanoic acid family (which includes diclofenac. ... Niflumic acid is a drug used for joint and muscular pain. ... Azapropazone is a non-steroidal anti-inflammatory drug. ... Glucosamine (C6H13NO5) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. ... Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat. ... Chondroitin sulfate Hyaluronan Glycosaminoglycans (GAGs) or mucopolysaccharides are long unbranched polysaccharides consisting of a repeating disaccharide unit. ... Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. ... Proquazone is a non-steroidal anti-inflammatory drug. ... Structure of the monomeric unit of human superoxide dismutase 2 The enzyme superoxide dismutase (SOD, EC 1. ... Nimesulide structure formula Nimesulide is a prescription non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. ... Feprazone (or prenazone) is a drug used for joint and muscular pain. ... Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. ... Morniflumate is a non-steroidal anti-inflammatory drug. ... Tenidap is a non-steroidal anti-inflammatory drug. ... Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis. ... Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) found in connective tissue and the nervous system, normally attached to a protein core. ... Disease-modifying antirheumatic drugs is a category of drugs used in many autoimmune diseases to slow down disease progression. ... Quinoline, also known as 1-azanaphthalene, 1-benzazine, or benzo[b]pyridine, is a heterocyclic aromatic organic compound. ... Oxycinchophen is an antirheumatic agent. ... Gold salts describe ionic chemical compounds of gold. ... Main article: Gold salts Sodium aurothiomalate (gold sodium thiomalate) is an organogold compound used for its antirheumatic effects to treat rheumatoid arthritis. ... Sodium aurothiosulfate is an antirheumatic agent. ... Main article: Gold salts Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. ... Main article: Gold salts Aurothioglucose (gold thioglucose) is an organogold compound used for its antirheumatic effects to treat rheumatoid arthritis. ... Aurotioprol is an antirheumatic agent. ...

Penicillamine/Bucillamine
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates  · Aspirin (Acetylsalicylic Acid) · Aloxiprin · Benorylate · Diflunisal · Ethenzamide · Magnesium salicylate · Methyl salicylate · Salsalate · Salicin · Salicylamide · Sodium salicylate ·
Arylalkanoic acids  · Diclofenac · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Etodolac · Indometacin · Indomethacin farnesil · Nabumetone · Oxametacin · Proglumetacin · Sulindac · Tolmetin ·
2-Arylpropionic acids
(profens)		  · Ibuprofen · Alminoprofen · Benoxaprofen · Carprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuproxam · Indoprofen · Ketoprofen · Ketorolac · Loxoprofen · Miroprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tarenflurbil · Tiaprofenic acid ·
N-Arylanthranilic acids
(fenamic acids)		  · Mefenamic acid · Flufenamic acid · Meclofenamic acid · Tolfenamic acid ·
Pyrazolidine derivatives  · Phenylbutazone · Ampyrone · Azapropazone · Clofezone · Kebuzone · Metamizole · Mofebutazone · Oxyphenbutazone · Phenazone · Sulfinpyrazone ·
Oxicams  · Piroxicam · Droxicam · Lornoxicam · Meloxicam · Tenoxicam ·
COX-2 inhibitors  · Celecoxib · Deracoxib · Etoricoxib · Lumiracoxib · Parecoxib · Rofecoxib · Valdecoxib ·
Sulphonanilides  · Nimesulide ·
Topically used products  · Bendazac · Diclofenac · Etofenamate · Felbinac · Flurbiprofen · Ibuprofen · Indometacin · Ketoprofen · Naproxen · Piroxicam · Suprofen ·
Others  · Fluproquazone · COX-inhibiting nitric oxide donator ·
Items listed in bold indicate initially developed compounds of specific groups
v • d • e
Analgesic products (N02A, N02B)
Opioids
See also: Opioids template		 Buprenorphine · Butorphanol · Codeine · Dextropropoxyphene · Diamorphine · Dihydrocodeine · Fentanyl · Hydrocodone · Hydromorphone · Ketobemidone · Levorphanol · Methadone · Morphine · Nalbuphine · Nicomorphine · Opium · Oxycodone · Oxymorphone · Pethidine · Tramadol · Tapentadol
Salicylic acid and derivatives Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Salicin · Salicylamide · See also: NSAIDs
Pyrazolones Ampyrone/Aminophenazone · Metamizole · Phenazone
Cannabinoids Cannabis · Tetrahydrocannabinol · AM404
Anilides Paracetamol (acetaminophen) · Phenacetin
Others Bicifadine · Diclofenac · Diflunisal · Duloxetine · Flupirtine · Flurbiprofen · Gabapentin · Ibuprofen · Indometacin · Ketorolac · Ketoprofen · Mefenamic acid · Meloxicam · Naproxen · Nefopam · Piroxicam · Ziconotide
Penicillamine is a pharmaceutical of the chelator class. ... Bucillamine is an antirheumatic agent. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Salicylic acid (from the Latin word for the willow tree, Salix, from whose bark it can be obtained) is a beta hydroxy acid (BHA) with the formula C6H4(OH)CO2H, where the OH group is adjacent to the carboxyl group. ... This article is about the drug. ... Aloxiprin (or aluminum acetylsalicylate) is a platelet aggregation inhibitor. ... Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). ... Ethenzamide is a common analgesic and antiinflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. ... Methyl salicylate (chemical formula C6H4(HO)COOCH3; also known as salicylic acid methyl ester, oil of wintergreen, betula oil, methyl-2-hydroxybenzoate) is a natural product of many species of plants. ... Salicylic acid is a colorless, crystalline organic carboxylic acid. ... Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. ... R-phrases , S-phrases , , Autoignition temperature > 250 °C Except where noted otherwise, data are given for materials in their standard state (at 25 Â°C, 100 kPa) Infobox disclaimer and references Sodium salicylate is a sodium salt of salicylic acid. ... my sister died form overdose!!! Diclofenac (marketed as Voltaren, Voltarol, Diclon, Dicloflex Difen, Difene, Cataflam, Pennsaid, Rhumalgan, Modifenac, Abitren and Zolterol) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and an analgesic reducing pain in conditions such as in arthritis or acute injury. ... Aceclofenac is a non-steroidal anti-inflammatory drug. ... Acemetacin is a non-steroidal anti-inflammatory drug. ... Alclofenac is a non-steroidal anti-inflammatory drug. ... Etodolac is the International Nonproprietary Name (INN) of 1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid (empirical formula C17H21NO3), also sold under the trade name Lodine. ... Indometacin (INN) or Indomethacin (USAN and former BAN) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ... Nabumetone is a non-steroidal anti-inflammatory drug of the arylalkanoic acid family (which includes diclofenac. ... Oxametacin (or oxamethacin) is a non-steroidal anti-inflammatory drug. ... Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. ... Sulindac is a non-steroidal anti-inflammatory drug of the arylalkanoic acid class that is marketed in the U.S. as Clinoril. ... Tolmetin (IPA: ) is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. ... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom... Alminoprofen is a non-steroidal anti-inflammatory drug. ... Benoxaprofen is a non-steroidal anti-inflammatory drug. ... Carprofen is a non-steroidal anti-inflammatory drug that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. ... Dexibuprofen is a non-steroidal anti-inflammatory drug. ... Dexketoprofen is a non-steroidal anti-inflammatory drug. ... Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. ... Fenoprofen is a non-steroidal anti-inflammatory drug. ... Flunoxaprofen is a non-steroidal anti-inflammatory drug. ... Flurbiprofen is an NSAID (non-steroidal anti-inflammatory drug) used to treat the inflammation and pain of arthritis. ... Ibuproxam is a non-steroidal anti-inflammatory drug. ... Indoprofen is a non-steroidal anti-inflammatory drug. ... Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. ... Ketorolac or ketorolac tromethamine (marketed as Toradol - generics have been approved) is a non-steroidal anti-inflammatory drug (NSAID) in the family of propionic acids, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. ... Loxoprofen (INN) is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group. ... Miroprofen is the INN name for the chemical compound p-Imidazo[1,2-a]pyridin-2-ylhydratropic acid, 2-[p-(2-imidazo[1,2-a]pyridyl)phenyl]propionic acid, or benzeneacetic acid, empirically C16H14N2O2. ... Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary... Oxaprozin (brand name: Daypro®) is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. ... Pirprofen is a non-steroidal anti-inflammatory drug. ... Suprofen is an NSAID marketed in a 1% solution under the trade name Profenal. ... Tiaprofenic acid is pharmaceutical, belonging to the class called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to treat pain, especially arthritic pain. ... Fenamic acid is a molecule which serves as a parent structure for several non-steroidal anti-inflammatory drugs, including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. ... Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. ... Flufenamic acid is a non-steroidal anti-inflammatory drug. ... Meclofenamic acid is a drug used for joint and muscular pain. ... Tolfenamic acid (TA) is one of the class of non steroidal anti-inflammatory drugs (NSAIDs). ... Pyrazolidine is a heterocyclic compound. ... Phenylbutazone, often known as bute, is a crystalline substance having the structure shown at right. ... Azapropazone is a non-steroidal anti-inflammatory drug. ... Clofezone is a drug used for joint and muscular pain. ... Kebuzone (or ketophenylbutazone) is a non-steroidal anti-inflammatory drug. ... Not to be confused with methimazole . ... Mofebutazone (or monophenylbutazone) is a drug used for joint and muscular pain. ... Phenylbutazone, often referred to as bute, is a crystalline substance having the structure shown at right. ... Phenazone, or phenazon, is an analgesic. ... Sulfinpyrazone is a uricosuric medication used to treat gout. ... Piroxicam Meloxicam An oxicam is a class of non-steroidal anti-inflammatory drugs which binds closely to plasma proteins. ... Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of Rheumatoid and Osteoarthritis, primary dysmenorrhoea, Post Operative Pain; and act as an analgesic, especially where there is an inflammatory component. ... Droxicam is a non-steroidal anti-inflammatory drug. ... Lornoxicam is a non-steroidal anti-inflammatory drug. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Tenoxicam is a non-steroidal anti-inflammatory drug. ... Cyclooxygenase (COX) is an enzyme (EC 1. ... COX-2 selective inhibitor is a form of Non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. ... Etoricoxib (brand name Arcoxia®) is a new COX-2 selective inhibitor from Merck & Co. ... Lumiracoxib (rINN) is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug, manufactured by Novartis and sold in 21 countries, including the United Kingdom, Mexico, Germany, South Africa, Australia, Argentina and Brazil, under the trade name Prexige® (sometimes misquoted as Prestige by the media). ... Injectible prodrug of valdecoxib. ... Rofecoxib (IPA: ) is a nonsteroidal anti-inflammatory drug (NSAID) developed by Merck & Co. ... Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. ... Nimesulide structure formula Nimesulide is a prescription non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. ... In medicine, a topical medication is applied to body surfaces such as the skin or mucous membranes such as the vagina, nasopharynx, or the eye. ... Bendazac (or bendazolic acid) is a non-steroidal anti-inflammatory drug used for joint and muscular pain. ... my sister died form overdose!!! Diclofenac (marketed as Voltaren, Voltarol, Diclon, Dicloflex Difen, Difene, Cataflam, Pennsaid, Rhumalgan, Modifenac, Abitren and Zolterol) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and an analgesic reducing pain in conditions such as in arthritis or acute injury. ... Etofenamate is a drug used for joint and muscular pain. ... Felbinac (or biphenylylacetic acid) is a topical medicine, belonging to the family of medicines known as NSAIDs, which is used to treat muscle inflammation and arthritis. ... Flurbiprofen is an NSAID (non-steroidal anti-inflammatory drug) used to treat the inflammation and pain of arthritis. ... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom... Indometacin (INN) or Indomethacin (USAN and former BAN) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ... Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. ... Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary... Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of Rheumatoid and Osteoarthritis, primary dysmenorrhoea, Post Operative Pain; and act as an analgesic, especially where there is an inflammatory component. ... Suprofen is an NSAID marketed in a 1% solution under the trade name Profenal. ... Fluproquazone (Tormosyl) is a quinazolinone derivative with potent analgesic[1][2] and antipyretic[3] effects and also anti-inflammatory action. ... An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain (achieve analgesia). ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... An opioid is a chemical substance that has a morphine-like action in the body. ... Buprenorphine, is an opioid drug with partial agonist and antagonist actions. ... Butorphanol (INN) is a morphinan-type synthetic opioid analgesic marketed in the U.S. under the trade name Stadol. ... Codeine (INN) or methylmorphine is an opiate used for its analgesic, antitussive and antidiarrheal properties. ... Dextropropoxyphene is an analgesic in the opioid category. ... For other uses, see Heroin (disambiguation). ... Dihydrocodeine, also called DHC, Drocode, Paracodeine and Parzone and by the brand names of Synalgos DC, Panlor DC, Panlor SS, SS Bron, Drocode, Paracodin, Codidol, Didor Continus, Dicogesic, Codhydrine, Dekacodin, DH-Codeine, Didrate, Dihydrin, Hydrocodin, Nadeine, Novicodin, Rapacodin, Fortuss, Dico, and DF-118 amongst others, is a semi-synthetic opioid... Fentanyl is an opioid analgesic, first synthesized by Janssen Pharmaceutica (Belgium) in the late 1950s, with a potency many times that of morphine. ... Hydrocodone or dihydrocodeinone is a semi-synthetic opioid derived from two of the naturally occurring opiates, codeine and thebaine. ... Hydromorphone is a drug developed in Germany in the 1920s and introduced to the mass market beginning in 1926. ... Ketobemidone structure Ketobemidone is a powerful opioid analgesic. ... Levorphanol is an opioid medication used to treat severe pain. ... Methadone (Dolophine®, Amidone®, Methadose®, Physeptone®, Heptadon® and many others) is a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use in patients on opioids. ... This article is about the drug. ... Nalbuphine (nalbuphine hydrochloride) is a synthetic opioid used commercially as an analgesic under a variety of trade names, including Nubain. ... Nicomorphine (Vilan) is the 3,6-dinicotinate ester of morphine. ... This article is about the drug. ... Not to be confused with oxytocin. ... Oxymorphone (Opana, Numorphan) or 14-Hydroxydihydromorphinone is a powerful semi-synthetic opioid analgesic that is derived from thebaine, and is approximately 6–8 times more potent than morphine. ... Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolargan® (in Poland);[1] Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ... Tramadol (INN) (IPA: ) is an atypical opioid which is a centrally acting analgesic, used for treating moderate to severe pain. ... Tapentadol (INN) is a centrally-acting analgesic with a unique dual mode of action as an agonist at the μ-opioid receptor and as a norepinephrine reuptake inhibitor. ... Salicylic acid (from the Latin word for the willow tree, Salix, from whose bark it can be obtained) is a beta hydroxy acid (BHA) with the formula C6H4(OH)CO2H, where the OH group is adjacent to the carboxyl group. ... This article is about the drug. ... Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). ... Ethenzamide is a common analgesic and antiinflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Salicylic acid is a colorless, crystalline organic carboxylic acid. ... Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. ... Pyrazole Phenazone Ampyrone Phenylbutazone Pyrazolone, a five-membered-ring lactam, is a derivative of pyrazole that has an additional keto (=O) group. ... Not to be confused with methimazole . ... Phenazone, or phenazon, is an analgesic. ... Cannabinoids are a group of terpenophenolic compounds present in Cannabis (Cannabis sativa L). ... This article is about the plant genus Cannabis. ... THC redirects here. ... AM404 AM404 also known as N-arachidonoylphenolamine is an active metabolite of Paracetamol (Acetaminophen) responsible for all or part of its analgesic action. ... Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2 (or C6H7N). ... Paracetamol (INN) (IPA: ) or acetaminophen (USAN), is the active metabolite of phenacetin, a so-called coal tar analgesic. ... Phenacetin, introduced in 1887, was used principally as an analgesic, and was the first fever reducer to go on the market. ... my sister died form overdose!!! Diclofenac (marketed as Voltaren, Voltarol, Diclon, Dicloflex Difen, Difene, Cataflam, Pennsaid, Rhumalgan, Modifenac, Abitren and Zolterol) is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and an analgesic reducing pain in conditions such as in arthritis or acute injury. ... Diflunisal is a generic NSAID (Non Steroidal Anti Inflammatory Drug). ... Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). ... Flurbiprofen is an NSAID (non-steroidal anti-inflammatory drug) used to treat the inflammation and pain of arthritis. ... Gabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. ... Ibuprofen (INN) (IPA: ) (from the earlier nomenclature iso-butyl-propanoic-phenolic acid) is a non-steroidal anti-inflammatory drug (NSAID) originally marketed as Nurofen and since under various trademarks, including Act-3, Advil, Brufen, Dorival, Herron Blue, Panafen, Motrin, Nuprin and Burana (Finland), Ipren or Ibumetin (Denmark and Sweden), Ibuprom... Indometacin (INN) or Indomethacin (USAN and former BAN) is a non-steroidal anti-inflammatory drug commonly used to reduce fever, pain, stiffness, and swelling. ... Ketorolac or ketorolac tromethamine (marketed as Toradol - generics have been approved) is a non-steroidal anti-inflammatory drug (NSAID) in the family of propionic acids, often used as an analgesic, antipyretic (fever reducer), and anti-inflammatory. ... Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. ... Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. ... Meloxicam is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. ... Naproxen (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, injury (like fractures), menstrual cramps, tendonitis, bursitis, and the treatment of primary... Categories: Possible copyright violations ... Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of Rheumatoid and Osteoarthritis, primary dysmenorrhoea, Post Operative Pain; and act as an analgesic, especially where there is an inflammatory component. ... Ziconotide is a non-opioid, non local anesthetic used for the amelioration of chronic pain. ...

  Results from FactBites:
 
The Drug Monitor - Celecoxib (Celebrex) - Nasr Anaizi, PhD (767 words)
Celecoxib is metabolized to inactive metabolites by the cytochrome P450 2C9.
Celecoxib is excreted in the milk of lactating animals and was found to be harmful to nursing infants.
Celecoxib is metabolized mainly by Cytochrome P450 2C9 and it is an inhibitor of the 2D6 isoform.
Celecoxib (1906 words)
Celecoxib (CELEBREX), approved by the Food and Drug Administration (FDA) for the symptomatic relief of osteoarthritis and rheumatoid arthritis, becomes the 20th member of the family known as nonsteroidal anti-inflammatory drugs, or NSAIDs for short.
Celecoxib is not approved by the FDA for the treatment of acute pain.
Celecoxib shares a chemical similarity to the sulfa drugs and should not be taken by people who are allergic to them.
  More results at FactBites »


 

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