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Dopamine and lewy bodies (9709 words) |
 | Alpha-synuclein co-exists with lipids in the Lewy bodies, a pathological hallmark of Parkinson's disease. |
| One of the key regulators of cell cycle progression is the retinoblastoma protein (pRb); therefore, we assessed the staining for pRb and its inactive hyperphosphorylated isoform, ppRb, in autopsy tissue from patients with PD. In PD we found abundant pRb staining in neuronal cytoplasm of the substantia nigra, mid-frontal cortex, and hippocampus by immunohistochemistry. |
| A pathologic hallmark is the presence of cytoplasmic eosinophilic inclusions (Lewy bodies) in monoamine neurons. |
| Neurons and Support Cells (8840 words) |
| The conspicuous nerve cell bodies in the ventral horn belong to spinal motor neurons. |
| Motor axons originate with cell bodies in the spinal cord's ventral horn or in the brainstem's motor nuclei or in peripheral sympathetic or parasympathetic ganglia. |
| Pyramidal cells are the efferent (long-axon) cells of the cerebral cortex. |
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