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Dr. Ann Erickson (504 words) |
 | The secreted protease is thought to aid tumor cell metastasis by participating in the degradation of the extracellular matrix through which the cells must migrate in order to establish secondary tumors. |
| The extensive precedent for secretion of the contents of multivesicular endosomes suggests that in response to signals, these protease-containing endosomes might fuse with the plasma membrane, a process that would dump a bolus of protease in a localized region outside a cell. |
| To understand the change in cellular targeting that occurs when synthesis of the protease increases, we are identifying cellular proteins that bind procathepsin L and thus potentially contribute to targeting the protease into the dense-core storage vesicles. |
| Directory — Biology Department - Penn State University (475 words) |
| By understanding how the secretion of neuropeptides is controlled at a cellular and molecular level we hope to shed some light on how this class of transmitter molecules are able to regulate higher-order behaviors. |
| There are clear distinctions in the synthesis, sub-cellular localization, secretion, and post-synaptic actions of neuropeptides and classical transmitters. |
| For example the two types of transmitters are even packaged into different cellular organelles: classical transmitters are found in small recycling vesicles, while neuropeptides are contained within large dense core granules that are filled via the trans Golgi network. |
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