Centauri Knights is a campaign setting for the roleplaying game Big Eyes, Small Mouth. It was written by David L. Pulver and published in 2001 by Guardians of Order. It is a science fiction setting centered around Osiris, a planet orbiting the star Alpha Centauri, and contains many transhumanist themes. A campaign setting is a fictional fantasy world which serves as a setting for a role-playing game or wargame, such as Dungeons & Dragons, Warhammer and various d20 System games. ... This article is about traditional role-playing games. ... Big Eyes, Small Mouth is a roleplaying game that was designed to simulate the action of anime and manga. ... 2001 is a common year starting on Monday of the Gregorian calendar. ... Guardians of Order is a Canadian company founded by Mark C. Mackinnon based out of Guelph, Ontario in the business of creating roleplaying games. ... The position of Alpha Centauri Alpha Centauri (α Cen / α Centauri) is the brightest star system in the southern constellation of Centaurus, and is the fourth brightest star in the sky, with a total visual magnitude of −0. ... Transhumanism is an emergent school of speculative philosophy analysing or favouring the use of science and technology, especially neurotechnology, biotechnology, and nanotechnology, to overcome human limitations and improve the human condition. ...

In this setting, interstellar travel is a new technology and requires human space travelers to be transplanted into cyborg bodies. The first human explorers to reach Osiris found the remains of a civilization and species that had been destroyed by a grey goo incident. The Osirans were users of nanotechnology, and humans known as "Fog Witches" are able to manipulate the nanomachines that are still in the atmosphere. The campaign setting centers around exploration of the ancient Osiran culture, the conflict between the Earth government and independence-minded colonists, and a cultural rebellion in which human colonists adopt Osiran ways. Interstellar space travel is unmanned or manned travel between stars, though the term usually denotes the latter. ... The term cyborg, a portmanteau of cybernetic organism, is used to designate a creature which is a mixture of organic and mechanical parts. ... Grey goo, a term coined by nanotechnology pioneer Eric Drexler, refers to a hypothetical end-of-the-world event involving nanotechnology in which out-of-control self-replicating robots consume all life on Earth while building more of themselves (a scenario known as ecophagy). ... A mite next to a gear chain produced using nanotechnology. ...

A d20 System version of this setting was published in 2004. The d20 System logo The d20 System is a system of game mechanics for role-playing games published in 2000 by Wizards of the Coast and based on the third edition of Dungeons & Dragons. ...