Central obesity (or 'apple-shaped' or 'masculine' obesity) occurs when the main deposits of body fat are localised around the abdomen and the upper body. Adipose tissue is an anatomical term for loose connective tissue composed of adipocytes. ... Template:In progress The human abdomen (from the Latin word meaning belly) is the part of the body between the pelvis and the thorax. ...

Associations

Central obesity is common in polycystic ovary syndrome (PCOS) and Syndrome X, and it is associated with a statistically higher risk of heart disease, hypertension, insulin resistance and diabetes mellitus type 2. Polycystic Ovary by Sonography Polycystic ovary syndrome (PCOS, also known clinically as Stein-Leventhal syndrome), is an endocrine disorder that affects 5–10% of women. ... Metabolic syndrome is a combination of medical disorders that affect a large number of people in a clustered fashion. ... There are different forms of heart disease: Coronary heart disease Ischaemic heart disease Cardiovascular disease The study of heart disease is Cardiology This is a disambiguation page — a navigational aid which lists pages that might otherwise share the same title. ... For other forms of hypertension see hypertension (disambiguation) Hypertension or high blood pressure is a medical condition where the blood pressure in the arteries is chronically elevated. ... In medicine, insulin resistance denotes a decompensation of glucose homeostasis where the tissues appear to be less responsive to insulin. ... Diabetes mellitus is a medical disorder characterized by varying or persistent hyperglycemia (elevated blood sugar levels), especially after eating. ...

Central obesity can also be a feature of lipodystrophies, a group of diseases which is either inherited, or due to secondary causes (often protease inhibitors, a group of medications against AIDS). In medicine, lipodystrophy is a condition characterized by abnormal or degernative conditions of the bodys fat tissue. ... A genetic disorder, or genetic disease is a disease caused, at least in part, by the genes of the person with the disease. ... Protease inhibitors are a class of medication used to treat or prevent viral infections. ... A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... Q: What is the first sign you may have contracted AIDS? A: A pounding sensation in the arse. ...

Diagnosis

Central obesity is diagnosed by measuring the waist-hip ratio. When this exceeds 0.9 in men or 0.8 in women, one can speak of central obesity.

Therapy

Weight loss is the main intervention against central obesity when this is considered disfiguring or when it puts one at a risk for the abovementioned diseases. Adjunctive therapies are the use of orlistat or sibutramine. In the presence of diabetes mellitus type 2, the physician might prefer to prescribe metformin and thiazolidinediones (rosiglitazone or pioglitazone) as anti-diabetic drugs rather than sulfonylurea derivatives. In the context of physical health, weight loss is the process of losing body weight, usually by losing fat. ... Orlistat (marketed as Xenical) is a drug designed to treat obesity. ... Sibutramine (Meridia® in the USA, Reductil® in Europe), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. ... Diabetes mellitus is a medical disorder characterized by varying or persistent hyperglycemia (elevated blood sugar levels), especially after eating. ... Metformin (Glucophage®, Fortamet®, Riomet®) is an anti-diabetic drug from the biguanide class (its other members are the withdrawn agents phenformin and buformin). ... The medication class of thiazolidinedione was introduced in the late 1990s as an adjunctive therapy for diabetes mellitus (type II) and related diseases. ... In medicine and pharmacology, rosiglitazone is a member of the thiazolidinedione class of drugs. ... In medicine and pharmacology, pioglitazone is a member of the drug class of the thiazolidinediones. ... http://kimoruni. ... Sulfonylurea derivatives are a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2 (adult-onset). They act by increasing insulin release from the beta cells in the pancreas. ...

See also

• Obesity
• Beer belly